Single-cell RNA-seq reveals the transcriptional landscape in ischemic stroke

Single-Cell RNA Sequencing With Combined Use of Bulk RNA Sequencing to Reveal Cell Heterogeneity and Molecular Changes at Acute Stage of Ischemic Stroke in Mouse Cortex Penumbra Area

(2021) Kang Guo et al.   Frontiers in Cell and Developmental Biology

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

(2020) Joanna Kalucka et al.   CELL

Transcriptomic and functional studies reveal undermined chemotactic and angiostimulatory properties of aged microglia during stroke recovery

(2020) Lu Jiang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Genome-wide transcriptomic analysis of microglia reveals impaired responses in aged mice after cerebral ischemia

(2020) Ligen Shi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Transcriptomic characterization of microglia activation in a rat model of ischemic stroke

(2020) Wenjun Deng et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*

(2020) Nathalie Percie du Sert et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Decoding the Transcriptional Response to Ischemic Stroke in Young and Aged Mouse Brain

(2020) Peter Androvic et al.   Cell Reports

Microglia/macrophage polarization: Fantasy or evidence of functional diversity?

(2020) Xiaoming Hu   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation

(2019) Marta Joana Costa Jordão et al.   SCIENCE

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

(2019) Carlos Silvestre-Roig et al.   NATURE

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

(2019) Hannah Van Hove et al.   NATURE NEUROSCIENCE

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Up-regulated microRNA-199b-3p represses the apoptosis of cerebral microvascular endothelial cells in ischemic stroke through down-regulation of MAPK/ERK/EGR1 axis

(2019) Ya-Xiong Yong et al.   CELL CYCLE

Global brain inflammation in stroke

(2019) Kaibin Shi et al.   LANCET NEUROLOGY

Current best practices in single‐cell RNA‐seq analysis: a tutorial

(2019) Malte D Luecken et al.   Molecular Systems Biology

The pro-remyelination properties of microglia in the central nervous system

(2019) Amy F. Lloyd et al.   Nature Reviews Neurology

Macrophages at CNS interfaces: ontogeny and function in health and disease

(2019) Katrin Kierdorf et al.   NATURE REVIEWS NEUROSCIENCE

Serum Amyloid A-Mediated Inflammasome Activation of Microglial Cells in Cerebral Ischemia

(2019) Jin Yu et al.   JOURNAL OF NEUROSCIENCE

Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module

(2019) Roeben Nocon Munji et al.   NATURE NEUROSCIENCE

The art of using t-SNE for single-cell transcriptomics

(2019) Dmitry Kobak et al.   Nature Communications

Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program

(2019) Laufey Geirsdottir et al.   CELL

Microglia and macrophages differ in their inflammatory profile after permanent brain ischemia

(2018) Juan G. Zarruk et al.   EXPERIMENTAL NEUROLOGY

Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

(2018) Maximilien Evrard et al.   IMMUNITY

Necrotizing enterocolitis is associated with acute brain responses in preterm pigs

(2018) Jing Sun et al.   Journal of Neuroinflammation

Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery

(2018) Peiying Li et al.   NEUROPHARMACOLOGY

Genome-wide transcriptome analysis using RNA-Seq reveals a large number of differentially expressed genes in a transient MCAO rat model

(2018) Lyudmila V. Dergunova et al.   BMC GENOMICS

Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures

(2018) Carole Sousa et al.   EMBO REPORTS

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

Microglial signatures and their role in health and disease

(2018) Oleg Butovsky et al.   NATURE REVIEWS NEUROSCIENCE

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

Single-cell mRNA quantification and differential analysis with Census

(2017) Xiaojie Qiu et al.   NATURE METHODS

Microglia: An Interface between the Loss of Neuroplasticity and Depression

(2017) Gaurav Singhal et al.   Frontiers in Cellular Neuroscience

Massively parallel digital transcriptional profiling of single cells

(2017) Grace X. Y. Zheng et al.   Nature Communications

Osteopontin as a Potential Therapeutic Target for Ischemic Stroke

(2017) Qiquan Zhu et al.   Current Drug Delivery

Stroke: a global response is needed

(2016) Walter Johnson et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Thiamet G mediates neuroprotection in experimental stroke by modulating microglia/macrophage polarization and inhibiting NF-κB p65 signaling

(2016) Yating He et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

(2016) S. Marques et al.   SCIENCE

Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq

(2016) Ozgun Gokce et al.   Cell Reports

Effect of Sema4D on microglial function in middle cerebral artery occlusion mice

(2015) Toshinori Sawano et al.   GLIA

Functional differences between microglia and monocytes after ischemic stroke

(2015) Rodney M. Ritzel et al.   Journal of Neuroinflammation

Sp3/REST/HDAC1/HDAC2 Complex Represses and Sp1/HIF-1/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism

(2015) L. Formisano et al.   JOURNAL OF NEUROSCIENCE

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Matrix Metalloproteinase-12 Induces Blood–Brain Barrier Damage After Focal Cerebral Ischemia

(2015) Bharath Chelluboina et al.   STROKE

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow

(2013) Sapna Devi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ets2 Determines the Inflammatory State of Endothelial Cells in Advanced Atherosclerotic Lesions

(2011) Caroline Cheng et al.   CIRCULATION RESEARCH

NF-κB and innate immunity in ischemic stroke

(2010) Olivier A. Harari et al.   Annals of the New York Academy of Sciences

Tumor Necrosis Factor-  (TNF- ) Regulates Shedding of TNF-  Receptor 1 by the Metalloprotease-Disintegrin ADAM8: Evidence for a Protease-Regulated Feedback Loop in Neuroprotection

(2010) J. W. Bartsch et al.   JOURNAL OF NEUROSCIENCE

Polycomb group protein-mediated repression of transcription

(2010) Lluís Morey et al.   TRENDS IN BIOCHEMICAL SCIENCES

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE