MicroRNA‐205‐5p targets E2F1 to promote autophagy and inhibit pulmonary fibrosis in silicosis through impairing SKP2‐mediated Beclin1 ubiquitination

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

(2020) Phuong-Uyen C. Dinh et al.   Nature Communications

Autophagic flux blockage in alveolar epithelial cells is essential in silica nanoparticle-induced pulmonary fibrosis

(2019) Xinyuan Zhao et al.   Cell Death & Disease

Beclin 1, LC3, and p62 expression in paraquat-induced pulmonary fibrosis

(2019) G Xu et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential

(2019) Li Qiao et al.   JOURNAL OF CLINICAL INVESTIGATION

Amino Acid Deprivation-Induced Autophagy Requires Upregulation of DIRAS3 through Reduction of E2F1 and E2F4 Transcriptional Repression

(2019) Margie N. Sutton et al.   Cancers

Autophagy, an important therapeutic target for pulmonary fibrosis diseases

(2019) Hong Zhao et al.   CLINICA CHIMICA ACTA

miR-205 Suppresses Pulmonary Fibrosis By Targeting GATA3 Through Inhibition Of Endoplasmic Reticulum Stress

(2019) Bingke Sun et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection

(2019) Nils C. Gassen et al.   Nature Communications

Resveratrol suppresses doxorubicin-induced cardiotoxicity by disrupting E2F1 mediated autophagy inhibition and apoptosis promotion

(2018) Jun Gu et al.   BIOCHEMICAL PHARMACOLOGY

MicroRNAs in idiopathic pulmonary fibrosis, new research progress and their pathophysiological implication

(2018) Chenggui Miao et al.   EXPERIMENTAL LUNG RESEARCH

Inhibiting Skp2 E3 Ligase Suppresses Bleomycin-Induced Pulmonary Fibrosis

(2018) Masashi Mikamo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MiR-205-5p and miR-342-3p cooperate in the repression of the E2F1 transcription factor in the context of anticancer chemotherapy resistance

(2018) Xin Lai et al.   Theranostics

Focusing on Coal Workers’ Lung Diseases: A Comparative Analysis of China, Australia, and the United States

(2018) Shuai Han et al.   International Journal of Environmental Research and Public Health

miR-1224-5p Mediates Mitochondrial Damage to Affect Silica-Induced Pulmonary Fibrosis by Targeting BECN1

(2017) Qiuyun Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of the Tumor-Suppressor BECLIN 1 by Distinct Ubiquitination Cascades

(2017) Fahd Boutouja et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dioscin Exerts Protective Effects Against Crystalline Silica-induced Pulmonary Fibrosis in Mice

(2017) Chao Li et al.   Theranostics

Differential regulation of autophagy and mitophagy in pulmonary diseases

(2016) Saurabh Aggarwal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Autophagy in Pulmonary Diseases

(2016) Kiichi Nakahira et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Skp2 Inhibitors: Novel Anticancer Strategies

(2016) Yeongju Lee et al.   CURRENT MEDICINAL CHEMISTRY

Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β

(2016) Ghulam Ilyas et al.   JOURNAL OF HEPATOLOGY

Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination

(2016) Chin-Chih Liu et al.   MOLECULAR CELL

Effects of bone marrow-derived mesenchymal stem cells on the autophagic activity of alveolar macrophages in a rat model of silicosis

(2016) HUI-XING ZHU et al.   Experimental and Therapeutic Medicine

Macrophage autophagy protects against liver fibrosis in mice

(2015) Jasper Lodder et al.   Autophagy

Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology

(2015) Beth Levine et al.   TRENDS IN CELL BIOLOGY

Adult Lung Spheroid Cells Contain Progenitor Cells and Mediate Regeneration in Rodents With Bleomycin-Induced Pulmonary Fibrosis

(2015) Eric Henry et al.   Stem Cells Translational Medicine

Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination

(2014) Congfeng Xu et al.   Autophagy

Epidermal growth factor upregulates Skp2/Cks1 and p27kip1in human extrahepatic cholangiocarcinoma cells

(2014) Ja-yeon Kim   WORLD JOURNAL OF GASTROENTEROLOGY

Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity

(2014) Zhonglei Lu et al.   Nature Communications

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

The oncoprotein HBXIP up-regulates Skp2 via activating transcription factor E2F1 to promote proliferation of breast cancer cells

(2013) Fuqiang Xu et al.   CANCER LETTERS

Epigenetics in Immune-Mediated Pulmonary Diseases

(2013) Yu Liu et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Decreased expression of autophagic beclin 1 protein in idiopathic pulmonary fibrosis fibroblasts

(2012) Alberto Ricci et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Silicosis

(2012) Chi Chiu Leung et al.   LANCET

NEDDylation controls the target specificity of E2F1 and apoptosis induction

(2012) I Aoki et al.   ONCOGENE

Autophagy

(2011) Jeffrey A. Haspel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

miRNA-205 Suppresses Melanoma Cell Proliferation and Induces Senescence via Regulation of E2F1 Protein

(2011) Altaf A. Dar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The RB-E2F1 Pathway Regulates Autophagy

(2010) H. Jiang et al.   CANCER RESEARCH

Transcriptional control of the cell cycle

(2009) Barbara Berckmans et al.   CURRENT OPINION IN PLANT BIOLOGY

E2F1 regulates autophagy and the transcription of autophagy genes

(2008) S Polager et al.   ONCOGENE