PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA

Senolytic CAR T cells reverse senescence-associated pathologies

(2020) Corina Amor et al.   NATURE

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Hallmarks of Cellular Senescence

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Identification of a DNA Damage–Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers

(2017) Jing Chen et al.   Cancer Discovery

The RNA Response to DNA Damage

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Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond

(2016) Jean-Christophe Marine et al.   Cold Spring Harbor Perspectives in Medicine

Antisense oligonucleotide–mediated MDM4 exon 6 skipping impairs tumor growth

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FL118 Induces p53-Dependent Senescence in Colorectal Cancer Cells by Promoting Degradation of MdmX

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Mdmx promotes genomic instability independent of p53 and Mdm2

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Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation

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DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

New insights into pre-mRNA processing factor 19: A multi-faceted protein in humans

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Lamin B1 loss is a senescence-associated biomarker

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MDM4 is a key therapeutic target in cutaneous melanoma

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Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence

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Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing

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The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome

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Widespread Overexpression of Epitope-Tagged Mdm4 Does Not Accelerate Tumor Formation In Vivo

(2010) S. De Clercq et al.   MOLECULAR AND CELLULAR BIOLOGY

The p53 orchestra: Mdm2 and Mdmx set the tone

(2010) Mark Wade et al.   TRENDS IN CELL BIOLOGY

Spliceosome Structure and Function

(2010) C. L. Will et al.   Cold Spring Harbor Perspectives in Biology

p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence

(2009) Kaori Fujita et al.   NATURE CELL BIOLOGY

Regulation of MDMX Expression by Mitogenic Signaling

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