CpG-Based Nanovaccines for Cancer Immunotherapy

Antibody Opsonization of a TLR9 Agonist–Containing Virus-like Particle Enhances In Situ Immunization

(2020) Caitlin D. Lemke-Miltner et al.   JOURNAL OF IMMUNOLOGY

A Novel C Type CpG Oligodeoxynucleotide Exhibits Immunostimulatory Activity In Vitro and Enhances Antitumor Effect In Vivo

(2020) Tete Li et al.   Frontiers in Pharmacology

Sequential and timely combination of cancer nanovaccine with immune checkpoint blockade effectively inhibits tumor growth and relapse

(2020) Sangyong Jon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Prevention of liver metastases through perioperative acute CpG-C immune stimulation

(2020) Liat Sorski et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Gold Nanoparticles for Drug Delivery and Cancer Therapy

(2020) Sarkar Siddique et al.   Applied Sciences-Basel

A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer

(2020) Qianqian Ni et al.   Science Advances

Lipid based nano carriers for cancer and tumor treatment

(2020) Mohammed Tahir Ansari et al.   CURRENT PHARMACEUTICAL DESIGN

Therapeutic nanovaccines sensitize EBV-associated tumors to checkpoint blockade therapy

(2020) Hong Liu et al.   BIOMATERIALS

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

(2020) Sarkar Siddique et al.   Nanomaterials

Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy

(2020) Jianghua Wang et al.   Advanced Science

Breast cancer-induced immune suppression in the sentinel lymph node is effectively countered by CpG-B in conjunction with inhibition of the JAK2/STAT3 pathway

(2020) Kim M van Pul et al.   Journal for ImmunoTherapy of Cancer

Mannose-Modified Liposome Co-Delivery of Human Papillomavirus Type 16 E7 Peptide and CpG Oligodeoxynucleotide Adjuvant Enhances Antitumor Activity Against Established Large TC-1 Grafted Tumors in Mice

(2020) Yan Zhao et al.   International Journal of Nanomedicine

Applications of Nanovaccines for Disease Prevention in Cattle

(2020) Teresia W. Maina et al.   Frontiers in Bioengineering and Biotechnology

A Visible Co-delivery Nanovaccine of Antigen and Adjuvant with Self-carrier for Cancer Immunotherapy

(2019) Xia Dong et al.   ACS Applied Materials & Interfaces

Nanovaccine: A novel approach in immunization

(2019) Seyed Mohammad Gheibi Hayat et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Delivery technologies for cancer immunotherapy

(2019) Rachel S. Riley et al.   NATURE REVIEWS DRUG DISCOVERY

Nanovaccines for cancer immunotherapy

(2019) Yu Zhang et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Nanoparticles and cancer therapy: Perspectives for application of nanoparticles in the treatment of cancers

(2019) Ali Aghebati‐Maleki et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Photodynamic Therapy Combined with Antihypoxic Signaling and CpG Adjuvant as an In Situ Tumor Vaccine Based on Metal–Organic Framework Nanoparticles to Boost Cancer Immunotherapy

(2019) Zhixiong Cai et al.   Advanced Healthcare Materials

Recent Advances in Nanovaccines Using Biomimetic Immunomodulatory Materials

(2019) Vijayan et al.   Pharmaceutics

Co-localized delivery of nanomedicine and nanovaccine augments the postoperative cancer immunotherapy by amplifying T-cell responses

(2019) Xiang Liu et al.   BIOMATERIALS

“Minimalist” Nanovaccine Constituted from Near Whole Antigen for Cancer Immunotherapy

(2018) Kun Wang et al.   ACS Nano

α-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effect in melanoma

(2018) Vanessa Sainz et al.   Acta Biomaterialia

Highly enhanced cancer immunotherapy by combining nanovaccine with hyaluronidase

(2018) Xiuwen Guan et al.   BIOMATERIALS

Nanoparticulate vaccine inhibits tumor growth via improved T cell recruitment into melanoma and huHER2 breast cancer

(2018) Eva Zupančič et al.   Nanomedicine-Nanotechnology Biology and Medicine

Lymphocytes eject interferogenic mitochondrial DNA webs in response to CpG and non-CpG oligodeoxynucleotides of class C

(2018) Björn Ingelsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In ovo administration of Toll-like receptor ligands encapsulated in PLGA nanoparticles impede tumor development in chickens infected with Marek’s disease virus

(2018) Jegarubee Bavananthasivam et al.   VACCINE

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

A C-type CpG ODN accelerates wound healing via regulating fibroblasts and immune response

(2018) Lina Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Nanoparticles for tumor immunotherapy

(2017) Xinlong Zang et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies

(2017) Nobutaka Hanagata   International Journal of Nanomedicine

CpG Type A Induction of an Early Protective Environment in Experimental Multiple Sclerosis

(2017) James Crooks et al.   MEDIATORS OF INFLAMMATION

Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy

(2017) Guizhi Zhu et al.   Nature Communications

Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy

(2017) Guizhi Zhu et al.   Nature Communications

Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase

(2017) Yoshinari Yamamoto et al.   Frontiers in Immunology

Microdosed Lipid-Coated 67Ga-Magnetite Enhances Antigen-Specific Immunity by Image Tracked Delivery of Antigen and CpG to Lymph Nodes

(2016) Ane Ruiz-de-Angulo et al.   ACS Nano

One-Shot Immunomodulatory Nanodiamond Agents for Cancer Immunotherapy

(2016) Yu Zhang et al.   ADVANCED MATERIALS

Targeting dendritic cells in lymph node with an antigen peptide-based nanovaccine for cancer immunotherapy

(2016) Yuan Qian et al.   BIOMATERIALS

Cancer immunotherapy: the beginning of the end of cancer?

(2016) Sofia Farkona et al.   BMC Medicine

Rationalizing the use of functionalized poly-lactic-co-glycolic acid nanoparticles for dendritic cell-based targeted anticancer therapy

(2016) Rutika A Kokate et al.   Nanomedicine

DNA–inorganic hybrid nanovaccine for cancer immunotherapy

(2016) Guizhi Zhu et al.   Nanoscale

Construction and Immunological Evaluation of CpG-Au@HBc Virus-Like Nanoparticles as a Potential Vaccine

(2016) Yarun Wang et al.   Nanoscale Research Letters

Designer vaccine nanodiscs for personalized cancer immunotherapy

(2016) Rui Kuai et al.   NATURE MATERIALS

Construction and Immunological Evaluation of CpG-Au@HBc Virus-Like Nanoparticles as a Potential Vaccine

(2016) Yarun Wang et al.   Nanoscale Research Letters

Self-Assembled DNA Immunonanoflowers as Multivalent CpG Nanoagents

(2015) Liqin Zhang et al.   ACS Applied Materials & Interfaces

Diaminosulfide based polymer microparticles as cancer vaccine delivery systems

(2015) Sean M. Geary et al.   JOURNAL OF CONTROLLED RELEASE

Enhancement of anti-tumor effect of particulate vaccine delivery system by ‘bacteriomimetic’ CpG functionalization of poly-lactic-co-glycolic acid nanoparticles

(2015) Rutika A Kokate et al.   Nanomedicine

Preparation and biomedical applications of programmable and multifunctional DNA nanoflowers

(2015) Yifan Lv et al.   Nature Protocols

Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer

(2014) Julia Scheiermann et al.   VACCINE

Modern Subunit Vaccines: Development, Components, and Research Opportunities

(2013) Peter Michael Moyle et al.   ChemMedChem

Recent progress concerning CpG DNA and its use as a vaccine adjuvant

(2013) Hidekazu Shirota et al.   Expert Review of Vaccines

Oligodeoxynucleotides Expressing Polyguanosine Motifs Promote Antitumor Activity through the Upregulation of IL-2

(2013) N. Kobayashi et al.   JOURNAL OF IMMUNOLOGY

Noncanonical Self-Assembly of Multifunctional DNA Nanoflowers for Biomedical Applications

(2013) Guizhi Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Coencapsulation of tumor lysate and CpG-ODN in PLGA-microspheres enables successful immunotherapy of prostate carcinoma in TRAMP mice

(2012) Marc Mueller et al.   JOURNAL OF CONTROLLED RELEASE

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

The Toll-like Receptor 9 Ligand CPG-C Attenuates Acute Inflammatory Cardiac Dysfunction

(2011) Sumeet Mathur et al.   SHOCK

Assessment of the Evolution of Cancer Treatment Therapies

(2011) Manuel Arruebo et al.   Cancers

Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells

(2010) X. Liang et al.   BLOOD

Nanoparticle Delivery Systems in Cancer Vaccines

(2010) Yogita Krishnamachari et al.   PHARMACEUTICAL RESEARCH

Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists

(2009) Jörg Vollmer et al.   ADVANCED DRUG DELIVERY REVIEWS

Immunization With Analog Peptide in Combination With CpG and Montanide Expands Tumor Antigen-specific CD8+ T Cells in Melanoma Patients

(2008) Julien Fourcade et al.   JOURNAL OF IMMUNOTHERAPY

Structural requirements for uptake and recognition of CpG oligonucleotides

(2007) Klaus Heeg et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY