AMD-Like Substrate Causes Epithelial Mesenchymal Transition in iPSC-Derived Retinal Pigment Epithelial Cells Wild Type but Not C3-Knockout

Tick‐over‐mediated complement activation is sufficient to cause basal deposit formation in cell‐based models of macular degeneration

(2021) Blanca Chinchilla et al.   JOURNAL OF PATHOLOGY

EMT and EndMT: Emerging Roles in Age-Related Macular Degeneration

(2020) Daisy Y. Shu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium Dysfunction

(2020) Mi Zhou et al.   Frontiers in Cell and Developmental Biology

Development and Optimization of an ELISA to Quantitate C3(H2O) as a Marker of Human Disease

(2019) Michelle Elvington et al.   Frontiers in Immunology

AAV-Mediated Gene Augmentation Therapy Restores Critical Functions in Mutant PRPF31+/− iPSC-Derived RPE Cells

(2019) Elizabeth M. Brydon et al.   Molecular Therapy-Methods & Clinical Development

Extracellular vesicle-mediated long-range communication in stressed retinal pigment epithelial cell monolayers

(2018) Navjot Shah et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

C3a triggers formation of sub-retinal pigment epithelium deposits via the ubiquitin proteasome pathway

(2018) Rosario Fernandez-Godino et al.   Scientific Reports

Changes in extracellular matrix cause RPE cells to make basal deposits and activate the alternative complement pathway

(2017) Rosario Fernandez-Godino et al.   HUMAN MOLECULAR GENETICS

Drusen in patient-derived hiPSC-RPE models of macular dystrophies

(2017) Chad A. Galloway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid, Directed Differentiation of Retinal Pigment Epithelial Cells from Human Embryonic or Induced Pluripotent Stem Cells

(2017) Leah P. Foltz et al.   Jove-Journal of Visualized Experiments

Extracellular matrix nitration alters growth factor release and activates bioactive complement in human retinal pigment epithelial cells

(2017) Mark A. Fields et al.   PLoS One

Molecular mechanisms of subretinal fibrosis in age-related macular degeneration

(2016) Keijiro Ishikawa et al.   EXPERIMENTAL EYE RESEARCH

Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility

(2016) Georgios Theocharidis et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Induced Pluripotent Stem Cell-Derived Retinal Pigmented Epithelium: A Comparative Study Between Cell Lines and Differentiation Methods

(2016) Lyndsay L. Leach et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Isolation, culture and characterization of primary mouse RPE cells

(2016) Rosario Fernandez-Godino et al.   Nature Protocols

Col4a1 mutations cause progressive retinal neovascular defects and retinopathy

(2016) Marcel V. Alavi et al.   Scientific Reports

A local complement response by RPE causes early-stage macular degeneration

(2015) Rosario Fernandez-Godino et al.   HUMAN MOLECULAR GENETICS

Complement Component 3 Is Regulated by TWIST1 and Mediates Epithelial–Mesenchymal Transition

(2015) Min Soon Cho et al.   JOURNAL OF IMMUNOLOGY

Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degeneration

(2015) Monte J. Radeke et al.   Genome Medicine

Age-Related Macular Degeneration: Genetics and Biology Coming Together

(2014) Lars G. Fritsche et al.   Annual Review of Genomics and Human Genetics

Age-related macular degeneration and changes in the extracellular matrix

(2014) Wanda Romaniuk   MEDICAL SCIENCE MONITOR

Mouse genetics and proteomic analyses demonstrate a critical role for complement in a model of DHRD/ML, an inherited macular degeneration

(2013) Donita L. Garland et al.   HUMAN MOLECULAR GENETICS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

The tick-over theory revisited: Is C3 a contact-activated protein?

(2012) Bo Nilsson et al.   IMMUNOBIOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells

(2011) K. Hu et al.   BLOOD

Shaping Cells and Organs in Drosophila by Opposing Roles of Fat Body-Secreted Collagen IV and Perlecan

(2011) José Carlos Pastor-Pareja et al.   DEVELOPMENTAL CELL

Chemically defined conditions for human iPSC derivation and culture

(2011) Guokai Chen et al.   NATURE METHODS

Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration

(2011) L. V. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3D reconstruction of histological sections: Application to mammary gland tissue

(2010) Ignacio Arganda-Carreras et al.   MICROSCOPY RESEARCH AND TECHNIQUE

The Tight Junction Associated Signalling Proteins ZO-1 and ZONAB Regulate Retinal Pigment Epithelium Homeostasis in Mice

(2010) Anastasios Georgiadis et al.   PLoS One

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease

(2009) Hervé Acloque et al.   JOURNAL OF CLINICAL INVESTIGATION

Biomarkers for epithelial-mesenchymal transitions

(2009) Michael Zeisberg et al.   JOURNAL OF CLINICAL INVESTIGATION

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

C3a Mediates Epithelial-to-Mesenchymal Transition in Proteinuric Nephropathy

(2009) Z. Tang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited

(2009) Don H. Anderson et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY