Changes in extracellular matrix cause RPE cells to make basal deposits and activate the alternative complement pathway

Isolation, culture and characterization of primary mouse RPE cells

(2016) Rosario Fernandez-Godino et al.   Nature Protocols

Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention

(2015) Dimitrios C. Mastellos et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

A local complement response by RPE causes early-stage macular degeneration

(2015) Rosario Fernandez-Godino et al.   HUMAN MOLECULAR GENETICS

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

(2015) Takeshi Maruyama et al.   NATURE BIOTECHNOLOGY

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

(2015) Van Trung Chu et al.   NATURE BIOTECHNOLOGY

The Membrane Attack Complex in Aging Human Choriocapillaris

(2014) Robert F. Mullins et al.   AMERICAN JOURNAL OF PATHOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Age-related macular degeneration and changes in the extracellular matrix

(2014) Wanda Romaniuk   MEDICAL SCIENCE MONITOR

Age-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation?

(2014) Alasdair Warwick et al.   Journal of Clinical Medicine

Mouse genetics and proteomic analyses demonstrate a critical role for complement in a model of DHRD/ML, an inherited macular degeneration

(2013) Donita L. Garland et al.   HUMAN MOLECULAR GENETICS

Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration

(2013) Johanna M Seddon et al.   NATURE GENETICS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Systemic Complement Inhibition with Eculizumab for Geographic Atrophy in Age-Related Macular Degeneration

(2013) Zohar Yehoshua et al.   OPHTHALMOLOGY

Interaction of Complement Factor H and Fibulin3 in Age-Related Macular Degeneration

(2013) M. Keith Wyatt et al.   PLoS One

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Age-Related Macular Degeneration Revisited – Piecing the Puzzle: The LXIX Edward Jackson Memorial Lecture

(2012) Joan W. Miller   AMERICAN JOURNAL OF OPHTHALMOLOGY

The tick-over theory revisited: Is C3 a contact-activated protein?

(2012) Bo Nilsson et al.   IMMUNOBIOLOGY

New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties

(2012) Hongchang Qu et al.   IMMUNOBIOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

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Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration

(2011) John D. Hulleman et al.   MOLECULAR BIOLOGY OF THE CELL

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Abundant Lipid and Protein Components of Drusen

(2010) Lan Wang et al.   PLoS One

Matrix metalloproteinase proteomics: substrates, targets, and therapy

(2009) Charlotte J Morrison et al.   CURRENT OPINION IN CELL BIOLOGY

A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells

(2009) Shozo Sonoda et al.   Nature Protocols

The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited

(2009) Don H. Anderson et al.   PROGRESS IN RETINAL AND EYE RESEARCH

New Components of ‘Basal Laminar Deposits’ in Age-Related Macular Degeneration

(2008) Enrico Reale et al.   CELLS TISSUES ORGANS

Fibrosis, chronic inflammation and new pathways for drug discovery

(2008) P. Sivakumar et al.   INFLAMMATION RESEARCH

The alternative complement pathway revisited

(2008) Morten Harboe et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tissue Inhibitor of Matrix Metalloproteinase-3 Levels in the Extracellular Matrix of Lung, Kidney, and Eye Increase With Age

(2008) Anne M. Macgregor et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

The tick-over theory revisited: Formation and regulation of the soluble alternative complement C3 convertase (C3(H2O)Bb)

(2007) Fredrik Bexborn et al.   MOLECULAR IMMUNOLOGY