The Mandibular and Hyoid Arches—From Molecular Patterning to Shaping Bone and Cartilage

Visualizing mesoderm and neural crest cell dynamics during chick head morphogenesis

(2020) Mary Cathleen McKinney et al.   DEVELOPMENTAL BIOLOGY

The development, patterning and evolution of neural crest cell differentiation into cartilage and bone

(2020) Soma Dash et al.   BONE

Neural crest cells require Meis2 for patterning the mandibular arch via the Sonic hedgehog pathway

(2020) Jaroslav Fabik et al.   Biology Open

The Syndrome of Elongated Styloid Process, the Eagle’s Syndrome—From Anatomical, Evolutionary and Embryological Backgrounds to 3D Printing and Personalized Surgery Planning. Report of Five Cases

(2020) Ladislav Czako et al.   Medicina-Lithuania

Diverse Fate of an Enigmatic Structure: 200 Years of Meckel’s Cartilage

(2020) Eva Svandova et al.   Frontiers in Cell and Developmental Biology

Hedgehog signaling patterns the oral-aboral axis of the mandibular arch

(2019) JIngyue Xu et al.   eLife

Diminution of pharyngeal segmentation and the evolution of the amniotes

(2019) Subathra Poopalasundaram et al.   Zoological Letters

A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates

(2019) Hugo J. Parker et al.   Nature Communications

MEIS2 gene is responsible for intellectual disability, cardiac defects and a distinct facial phenotype

(2019) Annarita Giliberti et al.   European Journal of Medical Genetics

Runx2 function in cells of neural crest origin during intramembranous ossification

(2019) Yukako Shirai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mandibular dysmorphology due to abnormal embryonic osteogenesis in FGFR2-related craniosynostosis mice

(2019) Susan M. Motch Perrine et al.   Disease Models & Mechanisms

Hedgehog signaling regulates osteoblast differentiation in zebrafish larvae through modulation of autophagy

(2019) Zhanying Hu et al.   Biology Open

MEIS transcription factors in development and disease

(2019) Dorothea Schulte et al.   DEVELOPMENT

A reappraisal and revision of the numbering of the pharyngeal arches

(2019) Anthony Graham et al.   JOURNAL OF ANATOMY

Molecular and cellular mechanisms underlying the evolution of form and function in the amniote jaw

(2019) Katherine C. Woronowicz et al.   EvoDevo

Fgf8a mutation affects craniofacial development and skeletal gene expression in zebrafish larvae

(2019) I. G. E. Gebuijs et al.   Biology Open

Sp7/osterix positively regulates dlx2b and bglap to affect tooth development and bone mineralization in zebrafish larvae

(2019) Zhongjian Chen et al.   JOURNAL OF BIOSCIENCES

The Roles of Indian Hedgehog Signaling in TMJ Formation

(2019) Till E. Bechtold et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development of the Human Incus With Special Reference to the Detachment From the Chondrocranium to be Transferred into the Middle Ear

(2018) Jose Francisco Rodríguez-Vázquez et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Coupling the roles of Hox genes to regulatory networks patterning cranial neural crest

(2018) Hugo J. Parker et al.   DEVELOPMENTAL BIOLOGY

De novo missense variants in MEIS2 recapitulate the microdeletion phenotype of cardiac and palate abnormalities, developmental delay, intellectual disability and dysmorphic features

(2018) Ganka Douglas et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Probing the origin of matching functional jaws: roles of Dlx5/6 in cranial neural crest cells

(2018) Miki Shimizu et al.   Scientific Reports

Conditional deletion of Bmp2 in cranial neural crest cells recapitulates Pierre Robin sequence in mice

(2018) Yixuan Chen et al.   CELL AND TISSUE RESEARCH

Heterozygous loss-of-function variants of MEIS2 cause a triad of palatal defects, congenital heart defects, and intellectual disability

(2018) Rosalind Verheije et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Specification and formation of the neural crest: Perspectives on lineage segregation

(2018) Maneeshi S. Prasad et al.   GENESIS

Abnormal ossification of the hyoid bone in cleidocranial dysplasia rare case and literature review

(2017) K. Yoshida et al.   INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

The development of the human hyoid-larynx complex revisited

(2017) Bernadette S. de Bakker et al.   LARYNGOSCOPE

ISLET1-Dependent β-Catenin/Hedgehog Signaling Is Required for Outgrowth of the Lower Jaw

(2017) Feixue Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Zinc finger transcription factor Sp7/Osterix acts on bone formation and regulates col10a1a expression in zebrafish

(2017) Pengfei Niu et al.   Science Bulletin

Hedgehog receptor function during craniofacial development

(2016) Guilherme M. Xavier et al.   DEVELOPMENTAL BIOLOGY

Meckel’s and condylar cartilages anomalies in achondroplasia result in defective development and growth of the mandible

(2016) Martin Biosse Duplan et al.   HUMAN MOLECULAR GENETICS

Exclusion ofDlx5/6expression from the distal-most mandibular arches enables BMP-mediated specification of the distal cap

(2016) Joshua W. Vincentz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Competition between Jagged-Notch and Endothelin1 Signaling Selectively Restricts Cartilage Formation in the Zebrafish Upper Face

(2016) Lindsey Barske et al.   PLoS Genetics

Hyoid Bone Abnormalities in Pierre Robin Patients

(2016) Christian A. El Amm et al.   JOURNAL OF CRANIOFACIAL SURGERY

Specification of jaw identity by the Hand2 transcription factor

(2016) Noriko Funato et al.   Scientific Reports

The Origin of the Variations of the Hyoid Apparatus in Human

(2015) José Francisco Rodríguez-Vázquez et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Meis2 is essential for cranial and cardiac neural crest development

(2015) Ondrej Machon et al.   BMC DEVELOPMENTAL BIOLOGY

Augmented Indian hedgehog signaling in cranial neural crest cells leads to craniofacial abnormalities and dysplastic temporomandibular joint in mice

(2015) Ling Yang et al.   CELL AND TISSUE RESEARCH

Hoxa2 Selectively Enhances Meis Binding to Change a Branchial Arch Ground State

(2015) Shilu Amin et al.   DEVELOPMENTAL CELL

Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation

(2015) Katherine Kretovich Billmyre et al.   DEVELOPMENTAL DYNAMICS

BMP Signaling Regulates Bone Morphogenesis in Zebrafish through Promoting Osteoblast Function as Assessed by Their Nitric Oxide Production

(2015) Thomas Windhausen et al.   MOLECULES

FGF8 signaling sustains progenitor status and multipotency of cranial neural crest-derived mesenchymal cellsin vivoandin vitro

(2015) Meiying Shao et al.   Journal of Molecular Cell Biology

Expression of osterix Is Regulated by FGF and Wnt/β-Catenin Signalling during Osteoblast Differentiation

(2015) Katharina Felber et al.   PLoS One

Haploinsufficiency ofMEIS2is associated with orofacial clefting and learning disability

(2014) Stefan Johansson et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis

(2014) B. A. Firulli et al.   DEVELOPMENT

Directed Bmp4 expression in neural crest cells generates a genetic model for the rare human bony syngnathia birth defect

(2014) Fenglei He et al.   DEVELOPMENTAL BIOLOGY

Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the β-catenin pathway

(2014) Ryutaro Akiyama et al.   DEVELOPMENTAL BIOLOGY

Endoderm-specific deletion ofTbx1reveals an FGF-independent role for Tbx1 in pharyngeal apparatus morphogenesis

(2014) Abigail Jackson et al.   DEVELOPMENTAL DYNAMICS

Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia

(2014) Noriko Funato et al.   HUMAN MOLECULAR GENETICS

Distinct Requirements for Cranial Ectoderm and Mesenchyme-Derived Wnts in Specification and Differentiation of Osteoblast and Dermal Progenitors

(2014) L. Henry Goodnough et al.   PLoS Genetics

Development and evolution of the pharyngeal apparatus

(2014) Aude Frisdal et al.   Wiley Interdisciplinary Reviews-Developmental Biology

SAMS, a Syndrome of Short Stature, Auditory-Canal Atresia, Mandibular Hypoplasia, and Skeletal Abnormalities Is a Unique Neurocristopathy Caused by Mutations in Goosecoid

(2013) David A. Parry et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Recurrent agnathia-otocephaly caused by DNA replication slippage inPRRX1

(2013) Majed Dasouki et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Osterix is required for cranial neural crest-derived craniofacial bone formation

(2013) Wook-Young Baek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enhanced BMP signaling prevents degeneration and leads to endochondral ossification of Meckel′s cartilage in mice

(2013) Ying Wang et al.   DEVELOPMENTAL BIOLOGY

Requirement for frzb and fzd7a in cranial neural crest convergence and extension mechanisms during zebrafish palate and jaw morphogenesis

(2013) George Kamel et al.   DEVELOPMENTAL BIOLOGY

Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates

(2013) E. Longobardi et al.   DEVELOPMENTAL DYNAMICS

A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis

(2013) Vida Senkus Melvin et al.   DEVELOPMENTAL DYNAMICS

Type 1 Fibroblast Growth Factor Receptor in Cranial Neural Crest Cell-derived Mesenchyme Is Required for Palatogenesis

(2013) Cong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Etiology of Cleft Palate Formation in BMP7-Deficient Mice

(2013) Thaleia Kouskoura et al.   PLoS One

edn1 and hand2 Interact in Early Regulation of Pharyngeal Arch Outgrowth during Zebrafish Development

(2013) Mark M. Sasaki et al.   PLoS One

Hedgehog-dependent proliferation drives modular growth during morphogenesis of a dermal bone

(2012) T. R. Huycke et al.   DEVELOPMENT

Bmp signaling regulates a dose-dependent transcriptional program to control facial skeletal development

(2012) M. Bonilla-Claudio et al.   DEVELOPMENT

Asymmetric requirement of surface epithelial β-catenin during the upper and lower jaw development

(2012) Ye Sun et al.   DEVELOPMENTAL DYNAMICS

Evolution of the mammalian middle ear and jaw: adaptations and novel structures

(2012) Neal Anthwal et al.   JOURNAL OF ANATOMY

Understanding morphology: a comparative study on the lower jaw in two teleost species

(2012) B Milligan et al.   JOURNAL OF APPLIED ICHTHYOLOGY

RUNX3, EGR1 and SOX9B Form a Regulatory Cascade Required to Modulate BMP-Signaling during Cranial Cartilage Development in Zebrafish

(2012) Julia Dalcq et al.   PLoS One

Prenatal diagnosis and identification of heterozygous frameshift mutation in PRRX1 in an infant with agnathia-otocephaly

(2012) Meghan Donnelly et al.   PRENATAL DIAGNOSIS

Imaging analysis of osteogenic transformation of Meckel's chondrocytes from green fluorescent protein-transgenic mice during intrasplenic transplantation

(2011) Kiyoto Ishizeki   ACTA HISTOCHEMICA

PRRX1 is mutated in an otocephalic newborn infant conceived by consanguineous parents

(2011) T Çelik et al.   CLINICAL GENETICS

PRRX1 is mutated in a fetus with agnathia-otocephaly

(2011) C Sergi et al.   CLINICAL GENETICS

Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis

(2011) F. Barron et al.   DEVELOPMENT

Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton

(2011) E. Zuniga et al.   DEVELOPMENT

Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton

(2011) C. Alexander et al.   DEVELOPMENT

Hox and Pbx Factors Control Retinoic Acid Synthesis during Hindbrain Segmentation

(2011) Antonio Vitobello et al.   DEVELOPMENTAL CELL

A Conserved Pbx-Wnt-p63-Irf6 Regulatory Module Controls Face Morphogenesis by Promoting Epithelial Apoptosis

(2011) Elisabetta Ferretti et al.   DEVELOPMENTAL CELL

Examination of a palatogenic gene program in zebrafish

(2011) Mary E. Swartz et al.   DEVELOPMENTAL DYNAMICS

Agnathia–otocephaly complex: A case report and examination of the OTX2 and PRRX1 genes

(2011) Sean Herman et al.   GENE

Noggin null allele mice exhibit a microform of holoprosencephaly

(2011) Eva Lana-Elola et al.   HUMAN MOLECULAR GENETICS

Human fetal hyoid body origin revisited

(2011) Jose Francisco Rodríguez-Vázquez et al.   JOURNAL OF ANATOMY

Ihh Signaling Regulates Mandibular Symphysis Development and Growth

(2011) H. Sugito et al.   JOURNAL OF DENTAL RESEARCH

The mechanism of TGF-β signaling during palate development

(2011) J Iwata et al.   ORAL DISEASES

Fuz Regulates Craniofacial Development through Tissue Specific Responses to Signaling Factors

(2011) Zichao Zhang et al.   PLoS One

Further evidence for the possible role ofMEIS2in the development of cleft palate and cardiac septum

(2010) Moira A. Crowley et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Clinical findings in patients with GLI2 mutations - phenotypic variability

(2010) CDP Bertolacini et al.   CLINICAL GENETICS

hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches

(2010) J. C. Talbot et al.   DEVELOPMENT

Hoxa1 lineage tracing indicates a direct role for Hoxa1 in the development of the inner ear, the heart, and the third rhombomere

(2010) Nadja Makki et al.   DEVELOPMENTAL BIOLOGY

Fibroblast growth factor 10 regulates Meckel's cartilage formation during early mandibular morphogenesis in rats

(2010) Fumie Terao et al.   DEVELOPMENTAL BIOLOGY

tgfβ3 regulation of chondrogenesis and osteogenesis in zebrafish is mediated through formation and survival of a subpopulation of the cranial neural crest

(2010) Felicia S.H. Cheah et al.   MECHANISMS OF DEVELOPMENT

Hedgehog signalling is required for perichondral osteoblast differentiation in zebrafish

(2010) Katharina Felber et al.   MECHANISMS OF DEVELOPMENT

Zebrafish wnt9a is expressed in pharyngeal ectoderm and is required for palate and lower jaw development

(2010) Eugene Curtin et al.   MECHANISMS OF DEVELOPMENT

Syndromes of the first and second pharyngeal arches: A review

(2009) Maria Rita Passos-Bueno et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Expression of osteogenic proteins during the intrasplenic transplantation of Meckel's chondrocytes: A histochemical and immunohistochemical study

(2009) Kiyoto Ishizeki et al.   ARCHIVES OF HISTOLOGY AND CYTOLOGY

Zebrafish con/disp1 reveals multiple spatiotemporal requirements for Hedgehog-signaling in craniofacial development

(2009) Tyler Schwend et al.   BMC DEVELOPMENTAL BIOLOGY

Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2

(2009) N. Funato et al.   DEVELOPMENT

Rostral and caudal pharyngeal arches share a common neural crest ground pattern

(2009) M. Minoux et al.   DEVELOPMENT

Two populations of endochondral osteoblasts with differential sensitivity to Hedgehog signalling

(2009) C. L. Hammond et al.   DEVELOPMENT

Meis Cofactors Control HDAC and CBP Accessibility at Hox-Regulated Promoters during Zebrafish Embryogenesis

(2009) Seong-Kyu Choe et al.   DEVELOPMENTAL CELL

Prx1andPrx2cooperatively regulate the morphogenesis of the medial region of the mandibular process

(2009) Anamaria Balic et al.   DEVELOPMENTAL DYNAMICS

Tracking gene expression during zebrafish osteoblast differentiation

(2009) Nan Li et al.   DEVELOPMENTAL DYNAMICS

FRS2αis required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus

(2009) Yoko Kameda et al.   DEVELOPMENTAL DYNAMICS

Forkhead transcription factor foxe1 regulates chondrogenesis in zebrafish

(2009) Chisako Nakada et al.   JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION

Dominant negative Bmp5 mutation reveals key role of BMPs in skeletal response to mechanical stimulation

(2008) Andrew M Ho et al.   BMC DEVELOPMENTAL BIOLOGY

Induction of mirror-image supernumerary jaws in chicken mandibular mesenchyme by Sonic Hedgehog-producing cells

(2008) J. M. Brito et al.   DEVELOPMENT

Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs

(2008) J. Jeong et al.   DEVELOPMENT

TGF-β mediated Dlx5 signaling plays a crucial role in osteo-chondroprogenitor cell lineage determination during mandible development

(2008) Kyoko Oka et al.   DEVELOPMENTAL BIOLOGY

barx1 is necessary for ectomesenchyme proliferation and osteochondroprogenitor condensation in the zebrafish pharyngeal arches

(2008) Steven M. Sperber et al.   DEVELOPMENTAL BIOLOGY

TGF-β type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner

(2008) Hu Zhao et al.   DEVELOPMENTAL BIOLOGY

Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice

(2008) Meilin Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell lineage in mammalian craniofacial mesenchyme

(2008) Toshiyuki Yoshida et al.   MECHANISMS OF DEVELOPMENT

A gene regulatory network orchestrates neural crest formation

(2008) Tatjana Sauka-Spengler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An endothelin-1 switch specifies maxillomandibular identity

(2008) T. Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deconstructing the pharyngeal metamere

(2007) Anthony Graham   JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION