SARS-CoV-2: Understanding the Transcriptional Regulation of ACE2 and TMPRSS2 and the Role of Single Nucleotide Polymorphism (SNP) at Codon 72 of p53 in the Innate Immune Response against Virus Infection

Genetic Variants of SARS-CoV-2—What Do They Mean?

(2021) Adam S. Lauring et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

SARS-CoV-2 Variants of Concern in the United States—Challenges and Opportunities

(2021) Rochelle P. Walensky et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages

(2021) Rebecca Gupte et al.   Nature Communications

SARS-CoV-2 Variants of Interest and Concern naming scheme conducive for global discourse

(2021) Frank Konings et al.   Nature Microbiology

The impact of PARPs and ADP-ribosylation on inflammation and host–pathogen interactions

(2020) Anthony R. Fehr et al.   GENES & DEVELOPMENT

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

(2020) Yushun Wan et al.   JOURNAL OF VIROLOGY

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toll-like Receptors and the Control of Immunity

(2020) Katherine A. Fitzgerald et al.   CELL

Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza

(2020) Timothy R. Abbott et al.   CELL

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection

(2020) Mihai G. Netea et al.   CELL

Coast-to-Coast Spread of SARS-CoV-2 during the Early Epidemic in the United States

(2020) Joseph R. Fauver et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

(2020) Zhuo Zhou et al.   Cell Host & Microbe

Respiratory virus infections: Understanding COVID-19

(2020) Kanta Subbarao et al.   IMMUNITY

SARS-CoV-2 Rates in BCG-Vaccinated and Unvaccinated Young Adults

(2020) Uri Hamiel et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The many faces of the anti-COVID immune response

(2020) Santosha A. Vardhana et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2)

(2020) Ruiyun Li et al.   SCIENCE

TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?

(2020) Konrad H. Stopsack et al.   Cancer Discovery

Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

(2020) Benjamin Israelow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Type III interferons disrupt the lung epithelial barrier upon viral recognition

(2020) Achille Broggi et al.   SCIENCE

Dexamethasone for COVID-19: data needed from randomised clinical trials in Africa

(2020) Helen Brotherton et al.   Lancet Global Health

COVID-19 poses a riddle for the immune system

(2020) Stanley Perlman   NATURE

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

(2020) Merryn Voysey et al.   LANCET

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Non-NAD-like PARP-1 inhibitors in prostate cancer treatment

(2019) Yaroslava Karpova et al.   BIOCHEMICAL PHARMACOLOGY

Non-specific effects of BCG vaccine on viral infections

(2019) S.J.C.F.M. Moorlag et al.   CLINICAL MICROBIOLOGY AND INFECTION

The codon 72 TP53 polymorphism contributes to TSC-tumorigenesis through the Notch-Nodal axis

(2019) Jun Hung Cho et al.   MOLECULAR CANCER RESEARCH

Interferon-Stimulated Genes: What Do They All Do?

(2019) John W. Schoggins   Annual Review of Virology

Direct Inhibition of IRF-Dependent Transcriptional Regulatory Mechanisms Associated With Disease

(2019) Aleksandra Antonczyk et al.   Frontiers in Immunology

RNA-Targeted Therapeutics

(2018) Stanley T. Crooke et al.   Cell Metabolism

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models

(2018) Yuhan Zhao et al.   eLife

A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses

(2018) Agata Michalska et al.   Frontiers in Immunology

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of ((S)-2,2-Difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

(2018) Andrew Fensome et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Dual Inhibition, a Better Solution: Development of a JAK1/TYK2 inhibitor

(2018) Christel J Menet   JOURNAL OF MEDICINAL CHEMISTRY

Damage-Associated Molecular Patterns in Inflammatory Diseases

(2018) Jong Seong Roh et al.   Immune Network

Phage-based vaccines

(2018) Qing Bao et al.   ADVANCED DRUG DELIVERY REVIEWS

Contrasting evolutionary genome dynamics between domesticated and wild yeasts

(2017) Jia-Xing Yue et al.   NATURE GENETICS

Single nucleotide polymorphisms and cancer susceptibility

(2017) Na Deng et al.   Oncotarget

A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages

(2017) Abigail J Morales et al.   eLife

Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay

(2016) Mizuki Yamamoto et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

Functionalization of an Antisense Small RNA

(2016) Guillermo Rodrigo et al.   JOURNAL OF MOLECULAR BIOLOGY

Reactive Oxygen Species Regulate T Cell Immune Response in the Tumor Microenvironment

(2016) Xinfeng Chen et al.   Oxidative Medicine and Cellular Longevity

Novel celecoxib analogues inhibit glial production of prostaglandin E2, nitric oxide, and oxygen radicals reverting the neuroinflammatory responses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide

(2016) Valentina Villa et al.   PHARMACOLOGICAL RESEARCH

Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease

(2016) Malgorzata Szelag et al.   Oncotarget

The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction

(2016) Che-Pei Kung et al.   Cell Reports

STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling Pathways

(2016) Johnathan Ho et al.   PLOS BIOLOGY

DNA Damage Response and Immune Defense: Links and Mechanisms

(2016) Rania Nakad et al.   Frontiers in Genetics

Non-NAD-Like poly(ADP-Ribose) Polymerase-1 Inhibitors effectively Eliminate Cancer in vivo

(2016) Colin Thomas et al.   EBioMedicine

Interferon regulatory factors: at the crossroads of immunity, metabolism, and disease

(2015) Guang-Nian Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

BCG-associated heterologous immunity, a historical perspective: intervention studies in animal models of infectious diseases

(2015) B. Freyne et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Gene polymorphisms in the folate metabolism and their association with MTX-related adverse events in the treatment of ALL

(2015) Yang Chen et al.   TUMOR BIOLOGY

On and off Metronomic Oral Vinorelbine in Elderly Women with Advanced Breast Cancer

(2015) Francesca De Iuliis et al.   TUMORI

On and off Metronomic Oral Vinorelbine in Elderly Women with Advanced Breast Cancer

(2015) Francesca De Iuliis et al.   TUMORI JOURNAL

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease

(2014) Mark D. Turner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

p53 and NF-κB Coregulate Proinflammatory Gene Responses in Human Macrophages

(2014) Julie M. Lowe et al.   CANCER RESEARCH

Transcriptional Roles of PARP1 in Cancer

(2014) Matthew J. Schiewer et al.   MOLECULAR CANCER RESEARCH

Kinase-Mediated Changes in Nucleosome Conformation Trigger Chromatin Decondensation via Poly(ADP-Ribosyl)ation

(2014) Colin J. Thomas et al.   MOLECULAR CELL

Bookmarking promoters in mitotic chromatin: poly(ADP-ribose)polymerase-1 as an epigenetic mark

(2014) Niraj Lodhi et al.   NUCLEIC ACIDS RESEARCH

The Androgen-Regulated Protease TMPRSS2 Activates a Proteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis

(2014) J. M. Lucas et al.   Cancer Discovery

Bookmarking by specific and nonspecific binding of FoxA1 pioneer factor to mitotic chromosomes

(2013) J. M. Caravaca et al.   GENES & DEVELOPMENT

RNA recognition by human TLR8 can lead to autoimmune inflammation

(2013) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-Specific Mitotic Bookmarking by Hematopoietic Transcription Factor GATA1

(2012) Stephan Kadauke et al.   CELL

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

TLR7 and TLR9 in SLE: when sensing self goes wrong

(2012) T. Celhar et al.   IMMUNOLOGIC RESEARCH

IFITM3 restricts the morbidity and mortality associated with influenza

(2012) A. Everitt et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Induction of Alternatively Activated Macrophages Enhances Pathogenesis during Severe Acute Respiratory Syndrome Coronavirus Infection

(2012) C. Page et al.   JOURNAL OF VIROLOGY

Were Equatorial Regions Less Affected by the 2009 Influenza Pandemic? The Brazilian Experience

(2012) Cynthia Schuck-Paim et al.   PLoS One

Poly(ADP-Ribose) Polymerase 1 (PARP-1) Regulates Ribosomal Biogenesis in Drosophila Nucleoli

(2012) Ernest K. Boamah et al.   PLoS Genetics

Tissue-specific apoptotic effects of the p53 codon 72 polymorphism in a mouse model

(2011) Gregory A. Azzam et al.   CELL CYCLE

JSH-23 targets nuclear factor-kappa B and reverses various deficits in experimental diabetic neuropathy: effect on neuroinflammation and antioxidant defence

(2011) A. Kumar et al.   DIABETES OBESITY & METABOLISM

Nitric oxide and redox mechanisms in the immune response

(2011) David A. Wink et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

(2011) I. Glowacka et al.   JOURNAL OF VIROLOGY

The Codon 72 Polymorphism of p53 Regulates Interaction with NF- B and Transactivation of Genes Involved in Immunity and Inflammation

(2011) A. K. Frank et al.   MOLECULAR AND CELLULAR BIOLOGY

Activator-Induced Spread of Poly(ADP-Ribose) Polymerase Promotes Nucleosome Loss at Hsp70

(2011) Steven J. Petesch et al.   MOLECULAR CELL

Identifying the regulatory element for human angiotensin-converting enzyme 2 (ACE2) expression in human cardiofibroblasts

(2011) Tang-Ching Kuan et al.   PEPTIDES

Drosophila histone H2A variant (H2Av) controls poly(ADP-ribose) polymerase 1 (PARP1) activation in chromatin

(2011) E. Kotova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The common germline Arg72Pro polymorphism of p53 and increased longevity in humans

(2010) Stig E. Bojesen et al.   CELL CYCLE

Immunogenicity of Whole-Parasite Vaccines against Plasmodium falciparum Involves Malarial Hemozoin and Host TLR9

(2010) Cevayir Coban et al.   Cell Host & Microbe

The roles of PARP1 in gene control and cell differentiation

(2010) Yingbiao Ji et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry

(2010) A. Shulla et al.   JOURNAL OF VIROLOGY

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

(2010) S. Matsuyama et al.   JOURNAL OF VIROLOGY

Lambda Interferon Is the Predominant Interferon Induced by Influenza A Virus Infection In Vivo

(2010) N. A. Jewell et al.   JOURNAL OF VIROLOGY

PARP-1 Regulates Chromatin Structure and Transcription through a KDM5B-Dependent Pathway

(2010) Raga Krishnakumar et al.   MOLECULAR CELL

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Differential levels of transcription of p53-regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis

(2009) Byeong-Seon Jeong et al.   FASEB JOURNAL

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

(2009) Giuseppe Mancuso et al.   NATURE IMMUNOLOGY

Coronaviruses post-SARS: update on replication and pathogenesis

(2009) Stanley Perlman et al.   NATURE REVIEWS MICROBIOLOGY

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL