Exploiting B Cell Transfer for Cancer Therapy: Engineered B Cells to Eradicate Tumors

Model-guided design of mammalian genetic programs

(2021) J. J. Muldoon et al.   Science Advances

T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours

(2021) Stefanie Lesch et al.   Nature Biomedical Engineering

Enhanced Immunogenicity of Engineered HER2 Antigens Potentiates Antitumor Immune Responses

(2020) Insu Jeon et al.   Vaccines

Activation of 4-1BBL+ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma

(2020) Catalina Lee-Chang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion

(2020) Alessio D. Nahmad et al.   Nature Communications

Precision Tools in Immuno-Oncology: Synthetic Gene Circuits for Cancer Immunotherapy

(2020) Giuliano Bonfá et al.   Vaccines

Reprogramming the antigen specificity of B cells using genome-editing technologies

(2019) James E Voss et al.   eLife

CAR-T cells : lymphocytes exprimant un récepteur chimérique à l’antigène

(2019) C. Chabannon et al.   REVUE DE MEDECINE INTERNE

B cells engineered to express pathogen-specific antibodies protect against infection

(2019) Howell F. Moffett et al.   Science Immunology

Humanized mice are precious tools for evaluation of hematopoietic gene therapies and preclinical modeling to move towards a clinical trial

(2019) Christian Brendel et al.   BIOCHEMICAL PHARMACOLOGY

Molecular Design, Optimization, and Genomic Integration of Chimeric B Cell Receptors in Murine B Cells

(2019) Theresa Pesch et al.   Frontiers in Immunology

Double-edge Role of B Cells in Tumor Immunity: Potential Molecular Mechanism

(2019) Kai-liang Zhao et al.   Current Medical Science

Engineering Protein-Secreting Plasma Cells by Homology-Directed Repair in Primary Human B Cells

(2018) King L. Hung et al.   MOLECULAR THERAPY

One‐step CRISPR/Cas9 method for the rapid generation of human antibody heavy chain knock‐in mice

(2018) Ying‐Cing Lin et al.   EMBO JOURNAL

Long-Term Persistence of Anti-HIV Broadly Neutralizing Antibody-Secreting Hematopoietic Cells in Humanized Mice

(2018) Anne-Sophie Kuhlmann et al.   MOLECULAR THERAPY

Engineering of Primary Human B cells with CRISPR/Cas9 Targeted Nuclease

(2018) Matthew J. Johnson et al.   Scientific Reports

Surface-Engineered Lentiviral Vectors for Selective Gene Transfer into Subtypes of Lymphocytes

(2018) Annika M. Frank et al.   Molecular Therapy-Methods & Clinical Development

GMP-production of purified human B lymphocytes for the adoptive transfer in patients after allogeneic hematopoietic stem cell transplantation

(2017) Hannes Tittlbach et al.   Journal of Translational Medicine

A Synthetic Mammalian Therapeutic Gene Circuit for Sensing and Suppressing Inflammation

(2017) Anže Smole et al.   MOLECULAR THERAPY

Smartphone-controlled optogenetically engineered cells enable semiautomatic glucose homeostasis in diabetic mice

(2017) Jiawei Shao et al.   Science Translational Medicine

Sensing and responding to allergic response cytokines through a genetically encoded circuit

(2017) Hélène Chassin et al.   Nature Communications

CAR T Cells Releasing IL-18 Convert to T-Bet high FoxO1 low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors

(2017) Markus Chmielewski et al.   Cell Reports

Using Antigen-Specific B Cells to Combine Antibody and T Cell–Based Cancer Immunotherapy

(2017) Kerstin Wennhold et al.   Cancer Immunology Research

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

(2016) Leonardo Morsut et al.   CELL

Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition

(2016) Jiangtao Ren et al.   CLINICAL CANCER RESEARCH

A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells

(2016) Florian J. Weisel et al.   IMMUNITY

Rewiring human cellular input–output using modular extracellular sensors

(2016) Kelly A Schwarz et al.   Nature Chemical Biology

Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system

(2016) Taek-Chin Cheong et al.   Nature Communications

B lymphocytes as direct antigen-presenting cells for anti-tumor DNA vaccines

(2016) Viswa Teja Colluru et al.   Oncotarget

CD40-activated B cells induce anti-tumor immunity in vivo

(2016) Kerstin Wennhold et al.   Oncotarget

Co-expression of CD40L with CD70 or OX40L increases B-cell viability and antitumor efficacy

(2016) Chang-Ae Shin et al.   Oncotarget

IL-2 augments the therapeutic efficacy of adoptively transferred B cells which directly kill tumor cells via the CXCR4/CXCL12 and perforin pathways

(2016) Yang Xia et al.   Oncotarget

Antitumor effector B cells directly kill tumor cells via the Fas/FasL pathway and are regulated by IL-10

(2015) Huimin Tao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TRUCKs: the fourth generation of CARs

(2015) Markus Chmielewski et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

A Lentiviral Vector Allowing Physiologically Regulated Membrane-anchored and Secreted Antibody Expression Depending on B-cell Maturation Status

(2015) Floriane Fusil et al.   MOLECULAR THERAPY

B Cells Loaded with Synthetic Particulate Antigens: A Versatile Platform To Generate Antigen-Specific Helper T Cells for Cell Therapy

(2015) Antoine Sicard et al.   NANO LETTERS

Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis

(2015) Lina Schukur et al.   Science Translational Medicine

Baboon envelope pseudotyped LVs outperform VSV-G-LVs for gene transfer into early-cytokine-stimulated and resting HSCs

(2014) A. Girard-Gagnepain et al.   BLOOD

Therapeutic Antitumor Efficacy of B Cells Loaded With Tumor-derived Autophagasomes Vaccine (DRibbles)

(2014) Hongyan Ren et al.   JOURNAL OF IMMUNOTHERAPY

A Novel and Effective Cancer Immunotherapy Mouse Model Using Antigen-Specific B Cells Selected In Vitro

(2014) Tatsuya Moutai et al.   PLoS One

Modular Extracellular Sensor Architecture for Engineering Mammalian Cell-based Devices

(2014) Nichole M. Daringer et al.   ACS Synthetic Biology

Enhanced antitumor immunotherapeutic effect of B-cell-based vaccine transduced with modified adenoviral vector containing type 35 fiber structures

(2013) E-K Kim et al.   GENE THERAPY

Targeting of Antigens to B Lymphocytes via CD19 as a Means for Tumor Vaccine Development

(2013) Y. Ma et al.   JOURNAL OF IMMUNOLOGY

IgG1+ ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells

(2012) S. K. Dougan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NKT ligand-loaded, antigen-expressing B cells function as long-lasting antigen presenting cells in vivo

(2011) Yeon-Jeong Kim et al.   CELLULAR IMMUNOLOGY

Adoptive Transfer of Tumor Reactive B Cells Confers Host T-Cell Immunity and Tumor Regression

(2011) Q. Li et al.   CLINICAL CANCER RESEARCH

Different B Cell Populations Mediate Early and Late Memory During an Endogenous Immune Response

(2011) K. A. Pape et al.   SCIENCE

CD40-Targeted Recombinant Adenovirus Significantly Enhances the Efficacy of Antitumor Vaccines Based on Dendritic Cells and B Cells

(2010) Yun-Sun Kim et al.   HUMAN GENE THERAPY

Efficient and stable transduction of resting B lymphocytes and primary chronic lymphocyte leukemia cells using measles virus gp displaying lentiviral vectors

(2009) C. Frecha et al.   BLOOD

Induction of protective cytotoxic T-cell responses by a B-cell-based cellular vaccine requires stable expression of antigen

(2009) S Guo et al.   GENE THERAPY

In Vivo Sensitized and In Vitro Activated B Cells Mediate Tumor Regression in Cancer Adoptive Immunotherapy

(2009) Q. Li et al.   JOURNAL OF IMMUNOLOGY

Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes.

(2008) X. M. Luo et al.   BLOOD

CD40-activated B cells can be generated in high number and purity in cancer patients: analysis of immunogenicity and homing potential

(2008) E. Kondo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Efficient antitumor immunity in a murine colorectal cancer model induced by CEA RNA-electroporated B cells

(2008) Mi-Young Park et al.   EUROPEAN JOURNAL OF IMMUNOLOGY