Design and Pharmacodynamics of Recombinant Fungus Defensin NZL with Improved Activity against Staphylococcus hyicus In Vitro and In Vivo

A new high-yielding antimicrobial peptide NZX and its antibacterial activity against Staphylococcus hyicus in vitro/vivo

(2020) He Liu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Therapeutic potential of a designed CSαβ peptide ID13 in Staphylococcus aureus-induced endometritis of mice

(2020) Bing Li et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

An Enhanced Variant Designed From DLP4 Cationic Peptide Against Staphylococcus aureus CVCC 546

(2020) Bing Li et al.   Frontiers in Microbiology

In vitro/vivo Mechanism of Action of MP1102 With Low/Nonresistance Against Streptococcus suis Type 2 Strain CVCC 3928

(2019) Fei Zhao et al.   Frontiers in Cellular and Infection Microbiology

A recombinant fungal defensin-like peptide-P2 combats multidrug-resistant Staphylococcus aureus and biofilms

(2019) Na Yang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism

(2019) Yinfeng Lyu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Designing and optimizing new antimicrobial peptides: all targets are not the same

(2019) Adriana Barreto-Santamaría et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Therapeutic Potential of Trp-Rich Engineered Amphiphiles by Single Hydrophobic Amino Acid End-Tagging

(2019) Jing Song et al.   ACS Applied Materials & Interfaces

Multiple Strategy Optimization of Specifically Targeted Antimicrobial Peptide Based on Structure–Activity Relationships to Enhance Bactericidal Efficiency

(2019) Peng Tan et al.   ACS Biomaterials-Science & Engineering

Autogenous vaccination reduces antimicrobial usage and mortality rates in a herd facing severe exudative epidermitis outbreaks in weaned pigs

(2018) Ioannis Arsenakis et al.   VETERINARY RECORD

Increased intracellular activity of MP1102 and NZ2114 against Staphylococcus aureus in vitro and in vivo

(2018) Xiao Wang et al.   Scientific Reports

Improved Antibacterial Activity of the Marine Peptide N6 against Intracellular Salmonella Typhimurium by Conjugating with the Cell-Penetrating Peptide Tat11 via a Cleavable Linker

(2018) Zhanzhan Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel derivative of the fungal antimicrobial peptide plectasin is active against Mycobacterium tuberculosis

(2018) Erik Tenland et al.   TUBERCULOSIS

A fatal suppurative pneumonia in piglets caused by a pathogenic coagulase-positive strain of Staphylococcus hyicus

(2017) Mingyue Wang et al.   VETERINARY RESEARCH COMMUNICATIONS

Antibacterial and detoxifying activity of NZ17074 analogues with multi-layers of selective antimicrobial actions against Escherichia coli and Salmonella enteritidis

(2017) Na Yang et al.   Scientific Reports

Killing of Staphylococcus aureus and Salmonella enteritidis and neutralization of lipopolysaccharide by 17-residue bovine lactoferricins: improved activity of Trp/Ala-containing molecules

(2017) Ya Hao et al.   Scientific Reports

Design and pharmacodynamics of recombinant NZ2114 histidine mutants with improved activity against methicillin-resistant Staphylococcus aureus

(2017) Huixian Chen et al.   AMB Express

In vitro and in vivo antibacterial effect of NZ2114 against Streptococcus suis type 2 infection in mice peritonitis models

(2017) Jian Jiao et al.   AMB Express

Antibacterial and immunomodulatory activities of insect defensins-DLP2 and DLP4 against multidrug-resistant Staphylococcus aureus

(2017) Zhanzhan Li et al.   Scientific Reports

Antimicrobial peptides

(2016) Ling-juan Zhang et al.   CURRENT BIOLOGY

Mechanisms and consequences of bacterial resistance to antimicrobial peptides

(2016) D.I. Andersson et al.   DRUG RESISTANCE UPDATES

In vitro and in vivo characterization of a new recombinant antimicrobial peptide, MP1102, against methicillin-resistant Staphylococcus aureus

(2015) Yong Zhang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

High expression of a plectasin-derived peptide NZ2114 in Pichia pastoris and its pharmacodynamics, postantibiotic and synergy against Staphylococcus aureus

(2013) Yong Zhang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

An investigation of resistance to β-lactam antimicrobials among staphylococci isolated from pigs with exudative epidermitis

(2013) Jeonghwa Park et al.   BMC Veterinary Research

Antimicrobial peptides stage a comeback

(2013) Jeffrey L Fox   NATURE BIOTECHNOLOGY

Antimicrobial Peptides for Therapeutic Applications: A Review

(2012) Min-Duk Seo et al.   MOLECULES

Staphylococcal skin disease in livestock

(2012) Aiden P. Foster   VETERINARY DERMATOLOGY

Efficacy of NZ2114, a Novel Plectasin-Derived Cationic Antimicrobial Peptide Antibiotic, in Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus

(2011) Yan Q. Xiong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Road to clinical efficacy: challenges and novel strategies for antimicrobial peptide development

(2011) Randal Eckert   Future Microbiology

Staphylococcus hyicus Bacteremia in a Farmer

(2011) C. Casanova et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Designing antimicrobial peptides: form follows function

(2011) Christopher D. Fjell et al.   NATURE REVIEWS DRUG DISCOVERY

Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II

(2010) Erik de Leeuw et al.   FEBS LETTERS

Human  -Defensin 3 Inhibits Cell Wall Biosynthesis in Staphylococci

(2010) V. Sass et al.   INFECTION AND IMMUNITY

Intracellular activity of the peptide antibiotic NZ2114: studies with Staphylococcus aureus and human THP-1 monocytes, and comparison with daptomycin and vancomycin

(2010) K. S. Brinch et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Plectasin, a Fungal Defensin, Targets the Bacterial Cell Wall Precursor Lipid II

(2010) T. Schneider et al.   SCIENCE

Alpha-helical cationic antimicrobial peptides: relationships of structure and function

(2010) Yibing Huang et al.   Protein & Cell

In Vivo Pharmacodynamic Characterization of a Novel Plectasin Antibiotic, NZ2114, in a Murine Infection Model

(2009) D. Andes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High Cerebrospinal Fluid (CSF) Penetration and Potent Bactericidal Activity in CSF of NZ2114, a Novel Plectasin Variant, during Experimental Pneumococcal Meningitis

(2009) C. Ostergaard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial Susceptibilities of Exfoliative Toxigenic and Non-Toxigenic Staphylococcus hyicus Strains in Japan

(2009) Keiko FUTAGAWA-SAITO et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations

(2009) Manuel N. Melo et al.   NATURE REVIEWS MICROBIOLOGY

Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances

(2008) Irith Wiegand et al.   Nature Protocols