Selective Inhibition of PDE4B Reduces Binge Drinking in Two C57BL/6 Substrains

Hnrnph1 is a novel regulator of alcohol reward

(2021) Elissa K. Fultz et al.   DRUG AND ALCOHOL DEPENDENCE

Alcoholic Neuropathy: Involvement Of Multifaceted Signalling Mechanisms.

(2020) Tapan Behl et al.   Current Molecular Pharmacology

KVA-D-88, a Novel Preferable Phosphodiesterase 4B Inhibitor, Decreases Cocaine-Mediated Reward Properties in Vivo

(2020) Maria E. Burkovetskaya et al.   ACS Chemical Neuroscience

Inbred Substrain Differences Influence Neuroimmune Response and Drinking Behavior

(2020) Anna S. Warden et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

The Phosphodiesterase-4 Inhibitor Roflumilast, a Potential Treatment for the Comorbidity of Memory Loss and Depression in Alzheimer’s Disease: A Preclinical Study in APP/PS1 Transgenic Mice

(2020) Hao Wang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Apremilast regulates acute effects of ethanol and other GABAergic drugs via protein kinase A-dependent signaling

(2020) Yuri A. Blednov et al.   NEUROPHARMACOLOGY

Incubation of Negative Affect during Protracted Alcohol Withdrawal Is Age-, but Not Sex-Selective

(2020) C. Leonardo Jimenez Chavez et al.   Brain Sciences

Phosphodiesterase-4 enzyme as a therapeutic target in neurological disorders

(2020) Abid Bhat et al.   PHARMACOLOGICAL RESEARCH

Ibudilast for alcohol use disorder: study protocol for a phase II randomized clinical trial

(2020) Elizabeth M. Burnette et al.   Trials

cAMP Signaling in Pathobiology of Alcohol Associated Liver Disease

(2020) Mohamed Elnagdy et al.   Biomolecules

C57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception

(2019) Camron D Bryant et al.   Molecular Pain

Increased alcohol-drinking induced by manipulations of mGlu5 phosphorylation within the bed nucleus of the stria terminalis

(2019) Rianne R. Campbell et al.   JOURNAL OF NEUROSCIENCE

Effects of Pharmacologically Targeting Neuroimmune Pathways on Alcohol Drinking in Mice Selectively Bred to Drink to Intoxication

(2019) Angela R. Ozburn et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Ibudilast attenuates peripheral inflammatory effects of methamphetamine in patients with methamphetamine use disorder

(2019) Michael J. Li et al.   DRUG AND ALCOHOL DEPENDENCE

Randomized, Placebo-Controlled Trial of Targeting Neuroinflammation with Ibudilast to Treat Methamphetamine Use Disorder

(2019) Keith G. Heinzerling et al.   Journal of Neuroimmune Pharmacology

Apremilast Alters Behavioral Responses to Ethanol in Mice: II. Increased Sedation, Intoxication, and Reduced Acute Functional Tolerance

(2018) Yuri A. Blednov et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Does the Neuroimmune Modulator Ibudilast Alter Food Craving? Results in a Sample With Alcohol Use Disorder

(2018) Jenna R. Cummings et al.   Journal of Addiction Medicine

Homer2 within the central nucleus of the amygdala modulates withdrawal-induced anxiety in a mouse model of binge-drinking

(2018) K.M. Lee et al.   NEUROPHARMACOLOGY

Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases

(2018) Heng Li et al.   Frontiers in Pharmacology

mGlu5 Receptor Blockade Within the Nucleus Accumbens Shell Reduces Behavioral Indices of Alcohol Withdrawal-Induced Anxiety in Mice

(2018) Kaziya M. Lee et al.   Frontiers in Pharmacology

Neuroimmune signaling in alcohol use disorder

(2018) Emma K. Erickson et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Effects of Ibudilast on the Subjective, Reinforcing, and Analgesic Effects of Oxycodone in Recently Detoxified Adults with Opioid Dependence

(2017) Verena E Metz et al.   NEUROPSYCHOPHARMACOLOGY

Development of the Neuroimmune Modulator Ibudilast for the Treatment of Alcoholism: A Randomized, Placebo-Controlled, Human Laboratory Trial

(2017) Lara A Ray et al.   NEUROPSYCHOPHARMACOLOGY

Complex interactions between the subject factors of biological sex and prior histories of binge-drinking and unpredictable stress influence behavioral sensitivity to alcohol and alcohol intake

(2017) Sema G. Quadir et al.   PHYSIOLOGY & BEHAVIOR

Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury

(2017) Nicole M. Wilson et al.   PLoS One

Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System

(2017) Chong Zhang et al.   Scientific Reports

Protein Kinase C Epsilon Activity in the Nucleus Accumbens and Central Nucleus of the Amygdala Mediates Binge Alcohol Consumption

(2016) Debra K. Cozzoli et al.   BIOLOGICAL PSYCHIATRY

Ibudilast attenuates subjective effects of methamphetamine in a placebo-controlled inpatient study

(2016) Matthew J. Worley et al.   DRUG AND ALCOHOL DEPENDENCE

Safety of Intravenous Methamphetamine Administration During Ibudilast Treatment

(2016) Dustin Z. DeYoung et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Chronic Cognitive Dysfunction after Traumatic Brain Injury Is Improved with a Phosphodiesterase 4B Inhibitor

(2016) D. J. Titus et al.   JOURNAL OF NEUROSCIENCE

Role of phosphodiesterase-4 on ethanol elicited locomotion and narcosis

(2016) Pablo Baliño et al.   NEUROPHARMACOLOGY

Homer2 regulates alcohol and stress cross-sensitization

(2015) Sema G. Quadir et al.   ADDICTION BIOLOGY

Phosphodiesterase regulation of alcohol drinking in rodents

(2015) Marian L. Logrip   ALCOHOL

Behavioral architecture of opioid reward and aversion in C57BL/6 substrains

(2015) Stacey L. Kirkpatrick et al.   Frontiers in Behavioral Neuroscience

Discovery of triazines as selective PDE4B versus PDE4D inhibitors

(2014) Timothy J. Hagen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity

(2014) P.H. Schafer et al.   CELLULAR SIGNALLING

Does Phosphodiesterase 11A (PDE11A) Hold Promise as a Future Therapeutic Target?

(2014) Michy Kelly   CURRENT PHARMACEUTICAL DESIGN

Phosphodiesterase: An Interface Connecting Cognitive Deficits to Neuropsychiatric and Neurodegenerative Diseases

(2014) Zhen-Zhen Wang et al.   CURRENT PHARMACEUTICAL DESIGN

Phosphodiesterases as Therapeutic Targets for Huntington’s Disease

(2014) Francesca Fusco et al.   CURRENT PHARMACEUTICAL DESIGN

Sex differences in SR Ca2+ release in murine ventricular myocytes are regulated by the cAMP/PKA pathway

(2014) Randi J. Parks et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior

(2014) Rolf T. Hansen et al.   PSYCHOPHARMACOLOGY

Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice

(2014) Yuri A. Blednov et al.   Frontiers in Neuroscience

Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence

(2013) Richard L. Bell et al.   ADDICTION BIOLOGY

“Drinking in the dark” (DID) procedures: A model of binge-like ethanol drinking in non-dependent mice

(2013) Todd E. Thiele et al.   ALCOHOL

Structural basis for the design of selective phosphodiesterase 4B inhibitors

(2013) David Fox et al.   CELLULAR SIGNALLING

Neuroimmune signaling: a key component of alcohol abuse

(2013) Jody Mayfield et al.   CURRENT OPINION IN NEUROBIOLOGY

Glial cell modulators attenuate methamphetamine self-administration in therat

(2013) Sarah E. Snider et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Binge Alcohol Drinking by Mice Requires Intact Group1 Metabotropic Glutamate Receptor Signaling Within the Central Nucleus of the Amygdale

(2013) Debra K Cozzoli et al.   NEUROPSYCHOPHARMACOLOGY

C57BL/6N Mutation in Cytoplasmic FMRP interacting protein 2 Regulates Cocaine Response

(2013) V. Kumar et al.   SCIENCE

The Phosphodiesterase-4 (PDE4) Inhibitor Rolipram Decreases Ethanol Seeking and Consumption in Alcohol-Preferring Fawn-Hooded Rats

(2012) Rui-Ting Wen et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Nucleus Accumbens mGluR5-Associated Signaling Regulates Binge Alcohol Drinking Under Drinking-in-the-Dark Procedures

(2012) Debra K. Cozzoli et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

The glial cell modulators, ibudilast and its amino analog, AV1013, attenuate methamphetamine locomotor activity and its sensitization in mice

(2012) Sarah E. Snider et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sex-related differences of cAMP-specific PDE4B3 mRNA in oligodendrocytes following systemic inflammation

(2012) Emily M. Johansson et al.   GLIA

Sequence-based characterization of structural variation in the mouse genome

(2011) Binnaz Yalcin et al.   NATURE

Mouse genomic variation and its effect on phenotypes and gene regulation

(2011) Thomas M. Keane et al.   NATURE

Strain differences in sucrose- and fructose-conditioned flavor preferences in mice

(2011) Alexander Pinhas et al.   PHYSIOLOGY & BEHAVIOR

Inhibition of phosphodiesterase-4 decreases ethanol intake in mice

(2011) Wei Hu et al.   PSYCHOPHARMACOLOGY

Antidepressant-like properties of phosphodiesterase type 5 inhibitors and cholinergic dependency in a genetic rat model of depression

(2010) Nico Liebenberg et al.   BEHAVIOURAL PHARMACOLOGY

The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D

(2010) F. Mori et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Behavioral profiles of three C57BL/6 substrains

(2010) Naoki Matsuo   Frontiers in Behavioral Neuroscience

Discovery of selective PDE4B inhibitors

(2009) Kenji Naganuma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Binge Drinking Upregulates Accumbens mGluR5-Homer2-PI3K Signaling: Functional Implications for Alcoholism

(2009) D. K. Cozzoli et al.   JOURNAL OF NEUROSCIENCE

The involvement of type IV phosphodiesterases in cocaine-induced sensitization and subsequent pERK expression in the mouse nucleus accumbens

(2009) Amy C. Janes et al.   PSYCHOPHARMACOLOGY

Alcohol trait and transcriptional genomic analysis of C57BL/6 substrains

(2008) M. K. Mulligan et al.   GENES BRAIN AND BEHAVIOR

Behavioral Differences among C57BL/6 Substrains: Implications for Transgenic and Knockout Studies

(2008) Camron D. Bryant et al.   JOURNAL OF NEUROGENETICS