Targeting SRC Kinase Signaling in Pancreatic Cancer Stem Cells

ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity

(2020) Sonia Alcalá et al.   Nature Communications

Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications

(2020) Wook Jin   Cancers

c-Src functionality controls self-renewal and glucose metabolism in MCF7 breast cancer stem cells

(2020) Víctor Mayoral-Varo et al.   PLoS One

Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells

(2020) Timothy P. Cash et al.   Cancers

Src Family Kinases as Therapeutic Targets in Advanced Solid Tumors: What We Have Learned So Far

(2020) Stefano Martellucci et al.   Cancers

Src-mediated phosphorylation, ubiquitination and degradation of Caveolin-1 promotes breast cancer cell stemness

(2019) Hyo-Jin Yoon et al.   CANCER LETTERS

Prognostic Biomarkers in Pancreatic Cancer: Avoiding Errata When Using the TCGA Dataset

(2019) Remy Nicolle et al.   Cancers

Direct Interactions With Cancer-Associated Fibroblasts Lead to Enhanced Pancreatic Cancer Stem Cell Function

(2019) Asma Begum et al.   PANCREAS

Molecular subtypes of pancreatic cancer

(2019) Eric A. Collisson et al.   Nature Reviews Gastroenterology & Hepatology

Signaling Networks that Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression and Metastasis

(2019) Howard C. Crawford et al.   GASTROENTEROLOGY

A phase I study of gemcitabine + dasatinib (gd) or gemcitabine + dasatinib + cetuximab (GDC) in refractory solid tumors

(2019) Niharika B. Mettu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo

(2019) Karolin Walter et al.   Stem Cells International

Combined Bcl-2/Src inhibition synergize to deplete stem-like breast cancer cells

(2019) Qi Sun et al.   CANCER LETTERS

Screening for Pancreatic Cancer

(2019) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Markers of pancreatic cancer stem cells and their clinical and therapeutic implications

(2019) Arkadiusz Gzil et al.   MOLECULAR BIOLOGY REPORTS

Personalized Cancer Therapy: YES1 Is the New Kid on the Block

(2019) Kunal Rai   CANCER RESEARCH

The therapeutic targeting of the FGFR1/Src/NF-κB signaling axis inhibits pancreatic ductal adenocarcinoma stemness and oncogenicity

(2018) Shiue-Wei Lai et al.   CLINICAL & EXPERIMENTAL METASTASIS

Dual Src and MEK inhibition decreases ovarian cancer growth and targets tumor initiating stem-like cells

(2018) Fiona Simpkins et al.   CLINICAL CANCER RESEARCH

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase

(2018) Dietrich A. Ruess et al.   NATURE MEDICINE

Common Co-activation of AXL and CDCP1 in EGFR -mutation-positive Non-Small Cell Lung Cancer Associated With Poor Prognosis

(2018) Niki Karachaliou et al.   EBioMedicine

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Pancreatic cancer stem cells: A state or an entity?

(2018) Patrick C. Hermann et al.   SEMINARS IN CANCER BIOLOGY

Cancer cell plasticity: Impact on tumor progression and therapy response

(2018) Victoria da Silva-Diz et al.   SEMINARS IN CANCER BIOLOGY

Dasatinib sensitises triple negative breast cancer cells to chemotherapy by targeting breast cancer stem cells

(2018) Jun Tian et al.   BRITISH JOURNAL OF CANCER

Targeting Cancer Stemness in the Clinic: From Hype to Hope

(2018) Caner Saygin et al.   Cell Stem Cell

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

miR205 inhibits stem cell renewal in SUM159PT breast cancer cells

(2017) Víctor Mayoral-Varo et al.   PLoS One

Inhibition of FAK kinase activity preferentially targets cancer stem cells

(2017) Vihren N. Kolev et al.   Oncotarget

Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma

(2016) Rekin’s Janky et al.   BMC CANCER

DNMT1 Inhibition Reprograms Pancreatic Cancer Stem Cells via Upregulation of the miR-17-92 Cluster

(2016) S. Zagorac et al.   CANCER RESEARCH

Expression of DRD2 Is Increased in Human Pancreatic Ductal Adenocarcinoma and Inhibitors Slow Tumor Growth in Mice

(2016) Pouria Jandaghi et al.   GASTROENTEROLOGY

GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer

(2016) Paola Martinelli et al.   GUT

The Interaction between Cancer Stem Cell Marker CD133 and Src Protein Promotes Focal Adhesion Kinase (FAK) Phosphorylation and Cell Migration

(2016) Chanjuan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mitogen-Activated Protein Kinase Pathway Facilitates Resistance to the Src Inhibitor Dasatinib in Thyroid Cancer

(2016) T. C. Beadnell et al.   MOLECULAR CANCER THERAPEUTICS

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

Epithelial–mesenchymal transition of ovarian cancer cells is sustained by Rac1 through simultaneous activation of MEK1/2 and Src signaling pathways

(2016) D Fang et al.   ONCOGENE

Inhibition of c-Yes induces differentiation of HT-29 human colon cancer stem cells through midbody elongation

(2016) Jessica Jung et al.   Tissue Engineering and Regenerative Medicine

Inhibition of c-Yes induces differentiation of HT-29 human colon cancer stem cells through midbody elongation

(2016) Jessica Jung et al.   Tissue Engineering and Regenerative Medicine

Pancreatic cancer

(2016) Jorg Kleeff et al.   Nature Reviews Disease Primers

miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple-Negative Breast Cancer

(2015) B. D. Adams et al.   CANCER RESEARCH

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

(2015) Patricia Sancho et al.   Cell Metabolism

Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment

(2015) Bruno Sainz et al.   GUT

The miR-17-92 cluster counteracts quiescence and chemoresistance in a distinct subpopulation of pancreatic cancer stem cells

(2015) Michele Cioffi et al.   GUT

Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action

(2015) Tobias Bartscht et al.   Molecular Cancer

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

(2015) Richard A Moffitt et al.   NATURE GENETICS

Cyr61 as mediator of Src signaling in triple negative breast cancer cells

(2015) María Pilar Sánchez-Bailón et al.   Oncotarget

Polarized cell migration induces cancer type-specific CD133/integrin/Src/Akt/GSK3β/β-catenin signaling required for maintenance of cancer stem cell properties

(2015) Ying-Jhen Su et al.   Oncotarget

Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer

(2015) Ravi Thakur et al.   Scientific Reports

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of CXCR4 and Hedgehog Signaling

(2014) A. Balic et al.   MOLECULAR CANCER THERAPEUTICS

Intracellular autofluorescence: a biomarker for epithelial cancer stem cells

(2014) Irene Miranda-Lorenzo et al.   NATURE METHODS

The Inhibition of Src Family Kinase Suppresses Pancreatic Cancer Cell Proliferation, Migration, and Invasion

(2014) Dong Wook Je et al.   PANCREAS

Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells

(2012) Eleftherios Sachlos et al.   CELL

Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells

(2012) María Pilar Sánchez-Bailón et al.   CELLULAR SIGNALLING

Regulation of the Src Family Kinases by Csk

(2012) Masato Okada   International Journal of Biological Sciences

EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer

(2012) Sandeep Singh et al.   Molecular Cancer

The Tyrosine Kinase c-Src Directly Mediates Growth Factor-Induced Notch-1 and Furin Interaction and Notch-1 Activation in Pancreatic Cancer Cells

(2012) Yong-Chao Ma et al.   PLoS One

Nodal/Activin Signaling Drives Self-Renewal and Tumorigenicity of Pancreatic Cancer Stem Cells and Provides a Target for Combined Drug Therapy

(2011) Enza Lonardo et al.   Cell Stem Cell

Functional Roles of Src and Fgr in Ovarian Carcinoma

(2011) H.-S. Kim et al.   CLINICAL CANCER RESEARCH

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

(2011) Eric A Collisson et al.   NATURE MEDICINE

Targeting Src family kinases in anti-cancer therapies: turning promise into triumph

(2011) Siyuan Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine

(2011) Jonghwan Kim et al.   Genome Medicine

Targeted Inhibition of Src Kinase Signaling Attenuates Pancreatic Tumorigenesis

(2010) Nagathihalli S. Nagaraj et al.   MOLECULAR CANCER THERAPEUTICS

A chemical and phosphoproteomic characterization of dasatinib action in lung cancer

(2010) Jiannong Li et al.   Nature Chemical Biology

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Src kinases as therapeutic targets for cancer

(2009) Lori C. Kim et al.   Nature Reviews Clinical Oncology

Acute promyelocytic leukemia: from highly fatal to highly curable

(2008) Z.-Y. Wang et al.   BLOOD

Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy

(2008) Jinyan Du et al.   NATURE BIOTECHNOLOGY

Activation of tyrosine kinases by mutation of the gatekeeper threonine

(2008) Mohammad Azam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signaling

(2008) I Ischenko et al.   ONCOGENE