Daphnetin inhibits spinal glial activation via Nrf2/HO-1/NF-κB signaling pathway and attenuates CFA-induced inflammatory pain

Daphnetin Ameliorates Experimental Autoimmune Encephalomyelitis Through Regulating Heme Oxygenase-1

(2020) Dan Wang et al.   NEUROCHEMICAL RESEARCH

The role of carbon monoxide, heme oxygenase 1, and the Nrf2 transcription factor in the modulation of chronic pain and their interactions with opioids and cannabinoids

(2020) Olga Pol   MEDICINAL RESEARCH REVIEWS

Quercetin Ameliorates CFA-Induced Chronic Inflammatory Hyperalgesia via Modulation of ROS-Mediated ERK1/2 Signaling and Inhibition of Spinal Glial Activation In Vivo

(2020) Sanjay Kumar et al.   NEUROMOLECULAR MEDICINE

Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain

(2020) Christopher R. Donnelly et al.   Neurotherapeutics

2-Bromopalmitate attenuates inflammatory pain by maintaining mitochondrial fission/fusion balance and function

(2020) Min Xie et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

HPLC-DAD-UV analysis, anti-inflammatory and anti-neuropathic effects of methanolic extract of Sideritis bilgeriana (lamiaceae) by NF-κB, TNF-α, IL-1β and IL-6 involvement

(2020) Mariana R.M. Cavalcanti et al.   JOURNAL OF ETHNOPHARMACOLOGY

Pharmacological Manipulation of Translation as a Therapeutic Target for Chronic Pain

(2020) Muhammad Saad Yousuf et al.   PHARMACOLOGICAL REVIEWS

Sex differences in central nervous system plasticity and pain in experimental autoimmune encephalomyelitis

(2019) Ana Catuneanu et al.   PAIN

Probucol Ameliorates Complete Freund’s Adjuvant-Induced Hyperalgesia by Targeting Peripheral and Spinal Cord Inflammation

(2019) Amanda Z. Zucoloto et al.   INFLAMMATION

Thymulin treatment attenuates inflammatory pain by modulating spinal cellular and molecular signaling pathways

(2019) Behzad Nasseri et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nrf2/HO-1 signaling pathway participated in the protection of hydrogen sulfide on neuropathic pain in rats

(2019) Hongguang Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Development of a daphnetin transdermal patch using chemical enhancer strategy: insights of the enhancement effect of Transcutol P and the assessment of pharmacodynamics

(2018) Meiyue Shen et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Anti-neuroinflammatory Effects of 12-Dehydrogingerdione in LPS-Activated Microglia through Inhibiting Akt/IKK/NF-κB Pathway and Activating Nrf-2/HO-1 Pathway

(2018) Dong Zhao et al.   Biomolecules & Therapeutics

Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide ( t -BHP)-induced mitochondrial dysfunction and cell death

(2017) Hongming Lv et al.   FREE RADICAL BIOLOGY AND MEDICINE

Treatment with Sulforaphane Produces Antinociception and Improves Morphine Effects during Inflammatory Pain in Mice

(2017) Alejandro Redondo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Innovative Opioid Peptides and Biased Agonism: Novel Avenues for More Effective and Safer Analgesics to Treat Chronic Pain

(2017) Andrea Bedini et al.   CURRENT MEDICINAL CHEMISTRY

Daphnetin ameliorates 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis through Nrf-2-Keap1 and NF-κB pathways

(2016) Abhishek Kumar et al.   BIOMEDICINE & PHARMACOTHERAPY

Daphnetin Alleviates Experimental Autoimmune Encephalomyelitis via Regulating Dendritic Cell Activity

(2016) Dan Wang et al.   CNS Neuroscience & Therapeutics

Interleukin-6: an emerging regulator of pathological pain

(2016) Ya-Qun Zhou et al.   Journal of Neuroinflammation

Probing the Effects and Mechanisms of Electroacupuncture at Ipsilateral or Contralateral ST36–ST37 Acupoints on CFA-induced Inflammatory Pain

(2016) Kung-Wen Lu et al.   Scientific Reports

Nuclear factor-kappa B regulates pain and COMT expression in a rodent model of inflammation

(2015) Jane E. Hartung et al.   BRAIN BEHAVIOR AND IMMUNITY

Ligustilide Ameliorates Inflammatory Pain and Inhibits TLR4 Upregulation in Spinal Astrocytes Following Complete Freund’s Adjuvant Peripheral Injection

(2015) Bin Qian et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Exogenous induction of HO-1 alleviates vincristine-induced neuropathic pain by reducing spinal glial activation in mice

(2015) Yan Shen et al.   NEUROBIOLOGY OF DISEASE

Persistent hindlimb inflammation induces changes in activation properties of hyperpolarization-activated current (Ih) in rat C-fiber nociceptors in vivo

(2015) L. Djouhri et al.   NEUROSCIENCE

NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review

(2015) Ruey-Horng Shih et al.   Frontiers in Molecular Neuroscience

Umbelliferone and daphnetin ameliorate carbon tetrachloride-induced hepatotoxicity in rats via nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1 expression

(2014) Mohamed R. Mohamed et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Daphnetin attenuates microglial activation and proinflammatory factor production via multiple signaling pathways

(2014) Wenwen Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anti-inflammatory and Protective Properties of Daphnetin in Endotoxin-Induced Lung Injury

(2014) Wen-wen Yu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Heme oxygenase/carbon monoxide-biliverdin pathway may be involved in the antinociceptive activity of etoricoxib, a selective COX-2 inhibitor

(2014) Niedja M.G. Grangeiro et al.   Pharmacological Reports

Pharmacological activation of heme oxygenase (HO)-1/carbon monoxide pathway prevents the development of peripheral neuropathic pain in Wistar rats

(2013) Krishna Reddy V. Bijjem et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Glia and pain: Is chronic pain a gliopathy?

(2013) Ru-Rong Ji et al.   PAIN

Review on Natural Coumarin Lead Compounds for Their Pharmacological Activity

(2013) K. N. Venugopala et al.   Biomed Research International

Inhibition of NF-κB nuclear translocation via HO-1 activation underlies α-tocopheryl succinate toxicity

(2012) Ilaria Bellezza et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats

(2012) Jia-Le Yang et al.   Molecular Brain

Regulatory effect of daphnetin, a coumarin extracted from Daphne odora, on the balance of Treg and Th17 in collagen-induced arthritis

(2011) Rongfeng Yao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells

(2011) Kamran Ghoreschi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blockade of TNF-α rapidly inhibits pain responses in the central nervous system

(2011) Andreas Hess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glial Cells and Chronic Pain

(2010) Romain-Daniel Gosselin et al.   NEUROSCIENTIST

Targeting astrocyte signaling for chronic pain

(2010) Yong-Jing Gao et al.   Neurotherapeutics

Role of interleukin-1β during pain and inflammation

(2009) Ke Ren et al.   BRAIN RESEARCH REVIEWS

Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Reduces Microglial and Astroglial Inflammatory Responses

(2009) S. Brahmachari et al.   JOURNAL OF IMMUNOLOGY

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

The IKK-NF-κB pathway: a source for novel molecular drug targets in pain therapy?

(2008) Ellen Niederberger et al.   FASEB JOURNAL

Therapeutic effects of daphnetin on adjuvant-induced arthritic rats

(2008) Qin Gao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Spinal glial activation contributes to pathological pain states

(2008) Hong Cao et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS