JWX-A0108, a positive allosteric modulator of α7 nAChR, attenuates cognitive deficits in APP/PS1 mice by suppressing NF-κB-mediated inflammation
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
JWX-A0108, a positive allosteric modulator of α7 nAChR, attenuates cognitive deficits in APP/PS1 mice by suppressing NF-κB-mediated inflammation
Authors
Keywords
α7 nAChRs, Positive allosteric modulator, JWX-A0108, Alzheimer's disease, APP/PS1 transgenic mice, Neuroinflammation
Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 96, Issue -, Pages 107726
Publisher
Elsevier BV
Online
2021-05-09
DOI
10.1016/j.intimp.2021.107726
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Mild behavioral impairment and its relation to tau pathology in preclinical Alzheimer’s disease
- (2021) Maurits Johansson et al. Translational Psychiatry
- Role of Nuclear factor kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach
- (2020) Shareen Singh et al. Current Neuropharmacology
- Amyloid-β, tau, and the cholinergic system in Alzheimer’s disease: seeking direction in a tangle of clues
- (2020) Alireza Majdi et al. REVIEWS IN THE NEUROSCIENCES
- Selective α7 nicotinic receptor agonists and positive allosteric modulators for the treatment of schizophrenia – a review
- (2020) Kirsten Antonio-Tolentino et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease
- (2020) Harald Hampel et al. Frontiers in Immunology
- Alpha 7 nicotinic receptor agonist and positive allosteric modulators improved social and molecular deficits of MK-801 model of schizophrenia in rats
- (2020) G. Unal et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signaling and neurotoxicity
- (2020) João Paulo Brás et al. Cell Death & Disease
- PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptor, directly inhibits p38 MAPK
- (2020) Junsuke Uwada et al. BIOCHEMICAL PHARMACOLOGY
- mRNA profiling reveals the potential mechanism of TIPE2 in attenuating cognitive deficits in APP/PS1 mice
- (2020) Zihan Xu et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Adult Neurogenesis, Glia, and the Extracellular Matrix
- (2019) Elise C. Cope et al. Cell Stem Cell
- Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer’s Disease
- (2019) François-Xavier Toublet et al. MOLECULES
- The Role of Protein Misfolding and Tau Oligomers (TauOs) in Alzheimer′s Disease (AD)
- (2019) Mroczko et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Nicotinic Mitigation of Neuroinflammation and Oxidative Stress After Chronic Sleep Deprivation
- (2019) Rong Xue et al. Frontiers in Immunology
- Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer’s Disease
- (2019) Federica Cioffi et al. JOURNAL OF ALZHEIMERS DISEASE
- Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors
- (2018) Michele Zoli et al. Current Neuropharmacology
- Microglia and macrophages differ in their inflammatory profile after permanent brain ischemia
- (2018) Juan G. Zarruk et al. EXPERIMENTAL NEUROLOGY
- The Cholinergic Anti-Inflammatory Response and the Role of Macrophages in HIV-Induced Inflammation
- (2018) Manuel Delgado-Vélez et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- α7 Nicotinic Acetylcholine Receptor
- (2018) Candace Jones JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice
- (2018) M. S. Unger et al. Journal of Neuroinflammation
- Nicotinic Acetylcholine Receptor Agonists for the Treatment of Alzheimer’s Dementia: An Update
- (2018) Justin L Hoskin et al. NICOTINE & TOBACCO RESEARCH
- Pharmacological characterization of JWX-A0108 as a novel type I positive allosteric modulator of α7 nAChR that can reverse acoustic gating deficits in a mouse prepulse inhibition model
- (2018) Li-lan Sun et al. ACTA PHARMACOLOGICA SINICA
- Microglia in Alzheimer’s disease
- (2017) David V. Hansen et al. JOURNAL OF CELL BIOLOGY
- First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288
- (2017) Kelvin W Gee et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Operation and plasticity of hippocampal CA3 circuits: implications for memory encoding
- (2017) Nelson Rebola et al. NATURE REVIEWS NEUROSCIENCE
- The current agonists and positive allosteric modulators of α 7 nAChR for CNS indications in clinical trials
- (2017) Taoyi Yang et al. Acta Pharmaceutica Sinica B
- Neuroinflammation in Alzheimer's disease: Current evidence and future directions
- (2016) Valeria Calsolaro et al. Alzheimers & Dementia
- Anti-inflammatory properties of the vagus nerve: potential therapeutic implications of vagus nerve stimulation
- (2016) Bruno Bonaz et al. JOURNAL OF PHYSIOLOGY-LONDON
- Alpha7 nicotinic receptors as therapeutic targets for Parkinson's disease
- (2015) Maryka Quik et al. BIOCHEMICAL PHARMACOLOGY
- Activation of the Macrophage α7 Nicotinic Acetylcholine Receptor and Control of Inflammation
- (2015) Carlos A. Báez-Pagán et al. Journal of Neuroimmune Pharmacology
- Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014
- (2014) L. S. Schneider et al. JOURNAL OF INTERNAL MEDICINE
- Recent Developments in Novel Antidepressants Targeting α4β2-Nicotinic Acetylcholine Receptors
- (2014) Li-Fang Yu et al. JOURNAL OF MEDICINAL CHEMISTRY
- α7-Nicotinic Acetylcholine Receptor Agonists for Cognitive Enhancement in Schizophrenia
- (2013) Robert Freedman Annual Review of Medicine
- Effects of neuronal nicotinic acetylcholine receptor allosteric modulators in animal behavior studies
- (2013) Anshul A. Pandya et al. BIOCHEMICAL PHARMACOLOGY
- The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain
- (2012) Megan M. Varnum et al. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
- Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: Advantages and limitations
- (2011) Dustin K. Williams et al. BIOCHEMICAL PHARMACOLOGY
- Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist
- (2011) Shu-Xing Li et al. NATURE NEUROSCIENCE
- Muscarinic and Nicotinic Acetylcholine Receptor Agonists and Allosteric Modulators for the Treatment of Schizophrenia
- (2011) Carrie K Jones et al. NEUROPSYCHOPHARMACOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now