Tripartite motif proteins: an emerging antiviral protein family

TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Influenza A Virus Infection

(2018) Girish Patil et al.   JOURNAL OF VIROLOGY

TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing

(2018) Gil Ju Seo et al.   Nature Communications

TRIM29 negatively controls antiviral immune response through targeting STING for degradation

(2018) Qijie Li et al.   Cell Discovery

Suppression of interferon-mediated anti-HBV response by single CpG methylation in the 5′-UTR ofTRIM22

(2017) Keo-Heun Lim et al.   GUT

Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5

(2017) Ming-Ming Hu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination

(2017) Yong Hu et al.   JOURNAL OF VIROLOGY

TRIM25 Is Required for the Antiviral Activity of Zinc Finger Antiviral Protein

(2017) Xiaojiao Zheng et al.   JOURNAL OF VIROLOGY

The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication

(2017) Preeti Bharaj et al.   JOURNAL OF VIROLOGY

TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP)

(2017) Melody M. H. Li et al.   PLoS Pathogens

Chloroquine triggers Epstein-Barr virus replication through phosphorylation of KAP1/TRIM28 in Burkitt lymphoma cells

(2017) Xiaofan Li et al.   PLoS Pathogens

Tripartite Motif 22 and Class II Transactivator Restriction Factors: Unveiling Their Concerted Action against Retroviruses

(2017) Greta Forlani et al.   Frontiers in Immunology

Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism

(2016) Wenchun Fan et al.   ANTIVIRAL RESEARCH

TRIM9 short isoform preferentially promotes DNA and RNA virus-induced production of type I interferon by recruiting GSK3β to TBK1

(2016) Yunfei Qin et al.   CELL RESEARCH

Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus

(2016) Ming-Ming Hu et al.   IMMUNITY

TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity

(2016) Xueting Lang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The C-Terminal Tail of TRIM56 Dictates Antiviral Restriction of Influenza A and B Viruses by Impeding Viral RNA Synthesis

(2016) Baoming Liu et al.   JOURNAL OF VIROLOGY

Nonhuman TRIM5 Variants Enhance Recognition of HIV-1-Infected Cells by CD8+T Cells

(2016) Esther Jimenez-Moyano et al.   JOURNAL OF VIROLOGY

The increasing complexity of the ubiquitin code

(2016) Richard Yau et al.   NATURE CELL BIOLOGY

Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract

(2016) Junji Xing et al.   NATURE IMMUNOLOGY

The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination

(2016) Bingyu Liu et al.   NATURE IMMUNOLOGY

T-cell–intrinsic Tif1α/Trim24 regulates IL-1R expression on TH2 cells and TH2 cell-mediated airway allergy

(2016) Jimena Perez-Lloret et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The interferon-induced antiviral protein PML (TRIM19) promotes the restriction and transcriptional silencing of lentiviruses in a context-specific, isoform-specific fashion

(2016) Nasser Masroori et al.   Retrovirology

An HIV-1 capsid binding protein TRIM11 accelerates viral uncoating

(2016) Ting Yuan et al.   Retrovirology

The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3

(2016) Hui Song et al.   Nature Communications

The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response

(2016) Preeti Bharaj et al.   PLoS Pathogens

TRIM14 inhibits hepatitis C virus infection by SPRY domain-dependent targeted degradation of the viral NS5A protein

(2016) Shanshan Wang et al.   Scientific Reports

TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A

(2016) Wenchun Fan et al.   Scientific Reports

Interferon alpha (IFNα)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A

(2015) Chen Yang et al.   Cellular & Molecular Immunology

TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms

(2015) Ming-Ming Hu et al.   JOURNAL OF IMMUNOLOGY

Identification of novel HIV-1 dependency factors in primary CCR4+CCR6+Th17 cells via a genome-wide transcriptional approach

(2015) Aurélie Cleret-Buhot et al.   Retrovirology

Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness

(2015) G. Manokaran et al.   SCIENCE

Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response

(2015) Yong Ran et al.   Journal of Molecular Cell Biology

TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase

(2015) Bishi Fu et al.   PLoS Pathogens

TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING

(2015) Yanming Wang et al.   PLoS Pathogens

The Interferon Signaling Antagonist Function of Yellow Fever Virus NS5 Protein Is Activated by Type I Interferon

(2014) Maudry Laurent-Rolle et al.   Cell Host & Microbe

Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKKε Kinase-Mediated Antiviral Response

(2014) Ricardo Rajsbaum et al.   IMMUNITY

The E3 Ubiquitin Ligase Tripartite Motif 33 Is Essential for Cytosolic RNA–Induced NLRP3 Inflammasome Activation

(2014) Leiyun Weng et al.   JOURNAL OF IMMUNOLOGY

Identification of TRIM27 as a Novel Degradation Target of Herpes Simplex Virus 1 ICP0

(2014) Sara E. Conwell et al.   JOURNAL OF VIROLOGY

TRIM13 Is a Negative Regulator of MDA5-Mediated Type I Interferon Production

(2014) K. Narayan et al.   JOURNAL OF VIROLOGY

Overlapping and Distinct Molecular Determinants Dictating the Antiviral Activities of TRIM56 against Flaviviruses and Coronavirus

(2014) B. Liu et al.   JOURNAL OF VIROLOGY

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

(2014) Xin Cai et al.   MOLECULAR CELL

TRIpartite Motif 21 (TRIM21) Differentially Regulates the Stability of Interferon Regulatory Factor 5 (IRF5) Isoforms

(2014) Elisa Lazzari et al.   PLoS One

TRIM38 inhibits TNF - and IL-1 -triggered NF- B activation by mediating lysosome-dependent degradation of TAB2/3

(2014) M.-M. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination

(2014) J. Yan et al.   Journal of Molecular Cell Biology

The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors

(2013) Gijs A. Versteeg et al.   IMMUNITY

Novel Function of Trim44 Promotes an Antiviral Response by Stabilizing VISA

(2013) B. Yang et al.   JOURNAL OF IMMUNOLOGY

TRIMmunity: The Roles of the TRIM E3-Ubiquitin Ligase Family in Innate Antiviral Immunity

(2013) Ricardo Rajsbaum et al.   JOURNAL OF MOLECULAR BIOLOGY

TRIM22 Inhibits Influenza A Virus Infection by Targeting the Viral Nucleoprotein for Degradation

(2013) A. Di Pietro et al.   JOURNAL OF VIROLOGY

TRIM11 Negatively Regulates IFNβ Production and Antiviral Activity by Targeting TBK1

(2013) Younglang Lee et al.   PLoS One

Identification and Characterization of Multiple TRIM Proteins That Inhibit Hepatitis B Virus Transcription

(2013) Shijian Zhang et al.   PLoS One

TRIM14 is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I-like receptor-mediated innate immune response

(2013) Z. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

(2012) Koraljka Husnjak et al.   Annual Review of Biochemistry

MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors

(2012) Céline Castanier et al.   BMC BIOLOGY

TRIM56 Is an Essential Component of the TLR3 Antiviral Signaling Pathway

(2012) Yang Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRIM32 Protein Modulates Type I Interferon Induction and Cellular Antiviral Response by Targeting MITA/STING Protein for K63-linked Ubiquitination

(2012) Jing Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E3 Ubiquitin Ligase Tripartite Motif 38 Negatively Regulates TLR-Mediated Immune Responses by Proteasomal Degradation of TNF Receptor-Associated Factor 6 in Macrophages

(2012) W. Zhao et al.   JOURNAL OF IMMUNOLOGY

Tripartite Motif-Containing Protein 38 Negatively Regulates TLR3/4- and RIG-I-Mediated IFN-  Production and Antiviral Response by Targeting NAP1

(2012) W. Zhao et al.   JOURNAL OF IMMUNOLOGY

TRIM27 Negatively Regulates NOD2 by Ubiquitination and Proteasomal Degradation

(2012) Birte Zurek et al.   PLoS One

The TRIM Family Protein KAP1 Inhibits HIV-1 Integration

(2011) Awatef Allouch et al.   Cell Host & Microbe

Tripartite Motif-Containing Protein 28 Is a Small Ubiquitin-Related Modifier E3 Ligase and Negative Regulator of IFN Regulatory Factor 7

(2011) Q. Liang et al.   JOURNAL OF IMMUNOLOGY

Role of Promyelocytic Leukemia Protein in Host Antiviral Defense

(2011) Marie-Claude Geoffroy et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

TRIM56 Is a Virus- and Interferon-Inducible E3 Ubiquitin Ligase That Restricts Pestivirus Infection

(2011) J. Wang et al.   JOURNAL OF VIROLOGY

Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2 

(2011) X. Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

(2010) Wenwen Zeng et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA

(2010) Tetsuo Tsuchida et al.   IMMUNITY

Tripartite-Motif Protein 30 Negatively Regulates NLRP3 Inflammasome Activation by Modulating Reactive Oxygen Species Production

(2010) Y. Hu et al.   JOURNAL OF IMMUNOLOGY

Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense

(2010) K.-i. Arimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

(2009) Michaela Ulrike Gack et al.   Cell Host & Microbe

Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain

(2009) Bo Gao et al.   HEPATOLOGY

Ro52-mediated Monoubiquitination of IKK  Down-regulates NF- B Signalling

(2009) K. Wada et al.   JOURNAL OF BIOCHEMISTRY

TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus

(2009) P. Eldin et al.   JOURNAL OF GENERAL VIROLOGY

TRIM21 Is Essential to Sustain IFN Regulatory Factor 3 Activation during Antiviral Response

(2009) K. Yang et al.   JOURNAL OF IMMUNOLOGY

Murine Gammaherpesvirus 68 Open Reading Frame 75c Tegument Protein Induces the Degradation of PML and Is Essential for Production of Infectious Virus

(2008) P. D. Ling et al.   JOURNAL OF VIROLOGY

TRIM30α negatively regulates TLR-mediated NF-κB activation by targeting TAB2 and TAB3 for degradation

(2008) Mude Shi et al.   NATURE IMMUNOLOGY

The Interferon Response Inhibits HIV Particle Production by Induction of TRIM22

(2008) Stephen D. Barr et al.   PLoS Pathogens