Resident memory CD8+ T cells in regional lymph nodes mediate immunity to metastatic melanoma

Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses

(2021) Jennifer A. Lo et al.   Science Translational Medicine

Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8+ T cells

(2020) Sarah L. Hayward et al.   NATURE IMMUNOLOGY

Organ-specific isoform selection of fatty acid–binding proteins in tissue-resident lymphocytes

(2020) H. Frizzell et al.   Science Immunology

Longevity and replenishment of human liver-resident memory T cells and mononuclear phagocytes

(2020) Laura J. Pallett et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients

(2020) Nicolas Gonzalo Núñez et al.   Nature Communications

Delivery technologies for cancer immunotherapy

(2019) Rachel S. Riley et al.   NATURE REVIEWS DRUG DISCOVERY

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

First-in-human phase 1 study of IT1208, a defucosylated humanized anti-CD4 depleting antibody, in patients with advanced solid tumors

(2019) Kohei Shitara et al.   Journal for ImmunoTherapy of Cancer

Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

(2019) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision

(2019) Zeyu Chen et al.   IMMUNITY

Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection

(2019) William H. Hudson et al.   IMMUNITY

An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

(2019) Caroline S. Jansen et al.   NATURE

Understanding Subset Diversity in T Cell Memory

(2018) Stephen C. Jameson et al.   IMMUNITY

T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells

(2018) Lalit K. Beura et al.   IMMUNITY

The function and dysfunction of memory CD8+ T cells in tumor immunity

(2018) James L. Reading et al.   IMMUNOLOGICAL REVIEWS

Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance

(2018) Thomas Gebhardt et al.   IMMUNOLOGICAL REVIEWS

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice

(2018) Ethel R. Pereira et al.   SCIENCE

Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice

(2018) M. Brown et al.   SCIENCE

Growth and Immune Evasion of Lymph Node Metastasis

(2018) Dennis Jones et al.   Frontiers in Oncology

RNA velocity of single cells

(2018) Gioele La Manno et al.   NATURE

Immune regulation of metastasis: mechanistic insights and therapeutic opportunities

(2018) Olga S. Blomberg et al.   Disease Models & Mechanisms

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

CD169+ Macrophages Capture and Dendritic Cells Instruct: The Interplay of the Gatekeeper and the General of the Immune System

(2018) Joanna Grabowska et al.   Frontiers in Immunology

Defining Memory CD8 T Cell

(2018) Matthew D. Martin et al.   Frontiers in Immunology

Tissue Resident CD8 Memory T Cell Responses in Cancer and Autoimmunity

(2018) Aleksey Molodtsov et al.   Frontiers in Immunology

The proportion of circulating CD45RO + CD8 + memory T cells is correlated with clinical response in melanoma patients treated with ipilimumab

(2017) Julia K. Tietze et al.   EUROPEAN JOURNAL OF CANCER

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

(2017) Youdong Pan et al.   NATURE

T-cell invigoration to tumour burden ratio associated with anti-PD-1 response

(2017) Alexander C. Huang et al.   NATURE

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours

(2017) J. Justin Milner et al.   NATURE

Single-cell mRNA quantification and differential analysis with Census

(2017) Xiaojie Qiu et al.   NATURE METHODS

Reversed graph embedding resolves complex single-cell trajectories

(2017) Xiaojie Qiu et al.   NATURE METHODS

Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma

(2017) Mark B. Faries et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

(2017) Michel Enamorado et al.   Nature Communications

Induction of resident memory T cells enhances the efficacy of cancer vaccine

(2017) Mevyn Nizard et al.   Nature Communications

Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites

(2017) Brahma V. Kumar et al.   Cell Reports

Prolonged Survival in Stage III Melanoma with Ipilimumab Adjuvant Therapy

(2016) Alexander M.M. Eggermont et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

(2016) L. K. Mackay et al.   SCIENCE

Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles

(2016) Frederick S. Varn et al.   Nature Communications

Association of Vitiligo With Tumor Response in Patients With Metastatic Melanoma Treated With Pembrolizumab

(2016) Camille Hua et al.   JAMA Dermatology

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer

(2016) Erica T. Goddard et al.   Jove-Journal of Visualized Experiments

Vitiligo-Like Depigmentation in Patients With Stage III-IV Melanoma Receiving Immunotherapy and Its Association With Survival: A Systematic Review and Meta-Analysis

(2015) Hansje-Eva Teulings et al.   JOURNAL OF CLINICAL ONCOLOGY

Cutting Edge: CD69 Interference with Sphingosine-1-Phosphate Receptor Function Regulates Peripheral T Cell Retention

(2015) Laura K. Mackay et al.   JOURNAL OF IMMUNOLOGY

Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial

(2015) Jeffrey S Weber et al.   LANCET ONCOLOGY

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

(2015) Eoin F. McKinney et al.   NATURE

Autoimmune Vitiligo Does Not Require the Ongoing Priming of Naive CD8 T Cells for Disease Progression or Associated Protection against Melanoma

(2014) K. T. Byrne et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Resident Memory CD8 T Cells Occupy Frontline Niches in Secondary Lymphoid Organs

(2014) J. M. Schenkel et al.   JOURNAL OF IMMUNOLOGY

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

Chemokine Guidance of Central Memory T Cells Is Critical for Antiviral Recall Responses in Lymph Nodes

(2012) Jung Hwan Sung et al.   CELL

IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis

(2012) Florent Carrette et al.   SEMINARS IN IMMUNOLOGY

Autoimmune melanocyte destruction is required for robust CD8+ memory T cell responses to mouse melanoma

(2011) Katelyn T. Byrne et al.   JOURNAL OF CLINICAL INVESTIGATION

Protective CD8 Memory T Cell Responses to Mouse Melanoma Are Generated in the Absence of CD4 T Cell Help

(2011) Anik L. Côté et al.   PLoS One

Type I Interferons Regulate Cytolytic Activity of Memory CD8+ T Cells in the Lung Airways during Respiratory Virus Challenge

(2010) Jacob E. Kohlmeier et al.   IMMUNITY

CD169-Positive Macrophages Dominate Antitumor Immunity by Crosspresenting Dead Cell-Associated Antigens

(2010) Kenichi Asano et al.   IMMUNITY

Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma

(2010) Jo Eyles et al.   JOURNAL OF CLINICAL INVESTIGATION

Cytokine-secreting follicular T cells shape the antibody repertoire

(2009) R Lee Reinhardt et al.   NATURE IMMUNOLOGY