Article
Virology
Mihkel Plaas, Kadri Seppa, Nayana Gaur, Priit Kasenomm, Mario Plaas
Summary: The study found a significant inverse correlation between ACE2 and age, as well as downregulation of NRP1 in patients with airway diseases. These results suggest that the interplay of various factors may influence susceptibility and disease progression.
Article
Multidisciplinary Sciences
Atish Gheware, Animesh Ray, Deeksha Rana, Prashant Bajpai, Aruna Nambirajan, S. Arulselvi, Purva Mathur, Anjan Trikha, Sudheer Arava, Prasenjit Das, Asit Ranjan Mridha, Geetika Singh, Manish Soneja, Neeraj Nischal, Sanjeev Lalwani, Naveet Wig, Chitra Sarkar, Deepali Jain
Summary: This study found significantly higher ACE2 protein expression in the lung tissues of deceased COVID-19 patients, which correlated with pathological changes and disease severity.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Satya Prakash Shukla, Kwang Bog Cho, Vineeta Rustagi, Xiang Gao, Xinping Fu, Shaun Xiaoliu Zhang, Bin Guo, D. Gomika Udugamasooriya
Summary: The study identified two ACE2-binding peptoid compounds that effectively block the entry of SARS-CoV-2 into human cells. These compounds also showed efficacy against a mutant virus and were found to be safe without reducing ACE2 expression or enzyme activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Darina Bacenkova, Marianna Trebunova, Tatiana Spakovska, Marek Schnitzer, Lucia Bednarcikova, Jozef Zivcak
Summary: COVID-19, caused by SARS-CoV-2, has ACE-2 identified as the receptor for viral entry and plays a key role in the cardiovascular system.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Sheng Niu, Jia Wang, Bin Bai, Lili Wu, Anqi Zheng, Qian Chen, Pei Du, Pengcheng Han, Yanfang Zhang, Yunfei Jia, Chengpeng Qiao, Jianxun Qi, Wen-xia Tian, Hong-Wei Wang, Qihui Wang, George Fu Gao
Summary: The study found that the RBDs of pangolin coronaviruses can bind to human ACE2, allowing entry of pseudotyped VSV particles into cells expressing ACE2, suggesting potential infectivity of these two pangolin coronaviruses in humans. Additionally, their ACE2 binding modes are similar to SARS-CoV-2, with a broader host range than SARS-CoV-2, indicating the need for further monitoring of pangolin coronaviruses.
Article
Biochemistry & Molecular Biology
Narcis Fernandez-Fuentes, Ruben Molina, Baldo Oliva
Summary: This article discusses the research on the interaction between SARS-CoV and SARS-CoV-2 coronaviruses and the ACE2 receptor. Researchers have designed peptides targeting the interaction of these viruses using structural data, which could be beneficial for the development of novel therapeutic and diagnostic agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Jan Wysocki, Minghao Ye, Luise Hassler, Ashwani Kumar Gupta, Yuguo Wang, Vlad Nicoleascu, Glenn Randall, Jason A. Wertheim, Daniel Batlle
Summary: A novel ACE2 variant has been developed that can neutralize SARS-CoV-2 infectivity in human kidney organoids, with prolonged duration of action and potential for improved efficacy.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mateja Mancek-Keber, Iva Hafner-Bratkovic, Dusko Lainscek, Mojca Bencina, Tea Govednik, Sara Orehek, Tjasa Plaper, Vid Jazbec, Valter Bergant, Vincent Grass, Andreas Pichlmair, Roman Jerala
Summary: Research has shown that the integrity of disulfide bonds within the RBD of the spike protein plays a crucial role in the membrane fusion process, although their disruption does not prevent the binding of the spike protein to ACE2. Additionally, several compounds have been found to inhibit viral entry into cells, offering insights for future therapeutic developments.
Article
Chemistry, Multidisciplinary
Sungwook Park, Hojun Kim, Kyungmin Woo, Jeong-Min Kim, Hye-Jun Jo, Youngdo Jeong, Kwan Hyi Lee
Summary: Researchers developed a biosensor based on the virus receptor to detect SARS-CoV-2 efficiently and sensitively, which may serve as an effective strategy for screening infectious diseases to prevent pandemics.
Article
Plant Sciences
Hsin Yeh, Di Ngoc Kha Vo, Zhi-Hu Lin, Ha Phan Thanh Ho, Wei-Jyun Hua, Wei-Lun Qiu, Ming-Han Tsai, Tung-Yi Lin
Summary: This study found that Ganoderma microsporum immunomodulatory protein (GMI) can block SARS-CoV-2 pseudovirus infection by inducing ACE2 degradation, suggesting its potential as a preventive agent against SARS-CoV-2 infection.
Article
Multidisciplinary Sciences
Yuanyuan Qiao, Xiao-Ming Wang, Rahul Mannan, Sethuramasundaram Pitchiaya, Yuping Zhang, Jesse W. Wotring, Lanbo Xiao, Dan R. Robinson, Yi-Mi Wu, Jean Ching-Yi Tien, Xuhong Cao, Stephanie A. Simko, Ingrid J. Apel, Pushpinder Bawa, Steven Kregel, Sathiya P. Narayanan, Gregory Raskind, Stephanie J. Ellison, Abhijit Parolia, Sylvia Zelenka-Wang, Lisa McMurry, Fengyun Su, Rui Wang, Yunhui Cheng, Andrew D. Delekta, Zejie Mei, Carla D. Pretto, Shaomeng Wang, Rohit Mehra, Jonathan Z. Sexton, Arul M. Chinnaiyan
Summary: Research has shown that androgens regulate the expression of ACE2, TMPRSS2, and AR in lung epithelial cells, affecting the risk of COVID-19 infection in males over 70 years old. The use of AR or BET antagonists can inhibit SARS-CoV-2 infection, providing support for further investigation into transcriptional inhibition for the treatment or prevention of COVID-19.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Thankamani Karthika, Jeswin Joseph, V. R. Akshay Das, Niranjana Nair, Packirisamy Charulekha, Melvin Daniel Roji, V. Stalin Raj
Summary: The cytoplasmic tail of ACE2 is not essential for the entry of SARS-CoV-1 and -2, suggesting that their entry may be mediated via known or unknown host factors. Inhibition of pseudotyped SARS-CoVs entry into cells was observed when treated with a dynamin inhibitor and an endosomal acidification inhibitor. Antibodies against SARS-CoV and soluble ACE2 were unable to enter cells expressing wtACE2 and increment cytACE2.
Article
Cell Biology
Rocio Diaz Escarcega, Pedram Honarpisheh, Gabriela Delevati Colpo, Hilda W. Ahnstedt, Lucy Couture, Shivanki Juneja, Glenda Torres, Guadalupe J. Ortiz, James Sollome, Natalie Tabor, Bhanu P. Ganesh, H. Alex Choi, Fudong Liu, Louise D. McCullough, Andrey S. Tsvetkov
Summary: The study finds sex differences in metabolism and sexual dimorphism in the correlations between clinical parameters and metabolic profiles in severe COVID-19 patients, providing important knowledge for the development of sex-associated biomarkers and druggable targets for COVID-19 patients.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Pedro F. N. Souza, Jackson L. Amaral, Leandro P. Bezerra, Francisco E. S. Lopes, Valder N. Freire, Jose T. A. Oliveira, Cleverson D. T. Freitas
Summary: Through in silico methods, it was found that ACE2-derived peptides could potentially interfere with the interaction between SARS-CoV-2 and the ACE2 receptor, inhibiting virus entry into human cells and providing new directions for treating COVID-19.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Rabea Victoria Niehues, Justyna Wozniak, Florian Wiersch, Eva Lilienthal, Nikola Tacken, Tim Schumertl, Christoph Garbers, Andreas Ludwig, Stefan Duesterhoeft
Summary: This study shows that ADAM10 is an important shedding protease for ACE2, and ACE2 can also be released in extracellular vesicles. The degree of ACE2 shedding mediated by ADAM10 and ADAM17 depends on stimulatory conditions and the expression level of the ADAM17 regulator iRhom2.
Article
Biochemical Research Methods
Chunmei Cui, Yuan Zhou, Qinghua Cui
Summary: The proposed functional divergence score (FDS) algorithm can effectively evaluate the functional differences between human and mouse orthologous genes, helping to uncover gene expression divergence and distinguish successful and failed drug targets.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Genetics & Heredity
Ruya Sun, Chunmei Cui, Yuan Zhou, Qinghua Cui
Summary: This study found a globally positive correlation between various biofluids and human tissues, but significantly varied consistency levels were observed between mRNA and lncRNA. Higher correlation was found between biofluid types and functionally related and anatomically closer tissues. Donor biological sex proved to be an important influencing factor in biofluid-tissue correlation.
Letter
Cell Biology
Chunmei Cui, Qinghua Cui
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Yingyu Lu, Wanlu Zhou, Qinghua Cui, Chunmei Cui
Summary: Stroke is a leading cause of death and disability worldwide, but treatment options are limited. LY2922470, a G protein-coupled receptor 40 (GPR40) agonist used for treating type 2 diabetes, has shown protective effects against ischemic stroke and improves brain damage. Administration of LY2922470 orally or through intraperitoneal injection can reduce infarct size and enhance motor skills in mice, suggesting its potential as a stroke therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chunmei Cui, Bitao Zhong, Rui Fan, Qinghua Cui
Summary: HMDD v4.0 is an important resource that curates 53530 microRNA-disease association entries, which is 1.5 times more than HMDD v3.0 released five years ago. New categories have been added, including exosomal miRNAs implicated in diseases, virus-encoded miRNAs involved in human diseases, and entries containing miRNA-circRNA interactions. Sex-biased miRNAs in diseases have also been curated.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Genetics & Heredity
Bitao Zhong, Chunmei Cui, Qinghua Cui
Summary: Significant differences between males and females in both physiology and disease necessitate the identification and analysis of sex-biased miRNAs. Previous studies have largely focused on healthy individuals or a single disease, making it necessary to comprehensively analyze sex-biased miRNAs in diseases. This study reveals that women have a greater number of highly expressed conserved miRNAs associated with a broader spectrum of diseases. Insights from this study could impact precision medicine and disease management.