Xanthohumol alleviated T2DM-induced liver steatosis and fibrosis by mediating the NRF2/RAGE/NF-κB signaling pathway

Xanthohumol protect cognitive performance in diabetic model rats by inhibiting protein kinase B/nuclear factor kappa-B pathway

(2021) Shanbo Ma et al.   NEUROREPORT

Xanthohumol ameliorates Diet-Induced Liver Dysfunction via Farnesoid X Receptor-Dependent and Independent Signaling

(2021) Ines L. Paraiso et al.   Frontiers in Pharmacology

Inhibition of the Nrf2/p38MAPK pathway involved in deltamethrin-induced apoptosis and fibrosis in quail kidney

(2021) Ning Deng et al.   FOOD AND CHEMICAL TOXICOLOGY

Differences in the Levels of the Selected Phytoestrogens and Stable Isotopes in Organic vs. Conventional Hops and Beer

(2021) Jelena B. Golubović et al.   Foods

Lactobacillus and Pediococcus ameliorate progression of non-alcoholic fatty liver disease through modulation of the gut microbiome

(2020) Na Young Lee et al.   Gut Microbes

Combination of xanthohumol and phenethyl isothiocyanate inhibits NF-κB and activates Nrf2 in pancreatic cancer cells

(2020) Violetta Krajka-Kuźniak et al.   TOXICOLOGY IN VITRO

Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis

(2020) Antje Mohs et al.   JOURNAL OF HEPATOLOGY

Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE/NF-κB signaling pathway in vivo and in vitro

(2020) Bo Ding et al.   Journal of Neuroinflammation

Naringin ameliorates type 2 diabetes mellitus-induced steatohepatitis by inhibiting RAGE/NF-κB mediated mitochondrial apoptosis

(2020) Anees Ahmed Syed et al.   LIFE SCIENCES

Oligo-Fucoidan Improves Diabetes-Induced Renal Fibrosis via Activation of Sirt-1, GLP-1R, and Nrf2/HO-1: An In Vitro and In Vivo Study

(2020) Wen-Chun Yu et al.   Nutrients

Exploring the liver fibrosis induced by deltamethrin exposure in quails and elucidating the protective mechanism of resveratrol

(2020) Siyu Li et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

The Development of Maillard Reaction, and Advanced Glycation End Product (AGE)-Receptor for AGE (RAGE) Signaling Inhibitors as Novel Therapeutic Strategies for Patients with AGE-Related Diseases

(2020) Chieh-Yu Shen et al.   MOLECULES

Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: A Bidirectional Relationship

(2020) Cristina M. Muzica et al.   Canadian Journal of Gastroenterology and Hepatology

Antiproliferative and Cytotoxic Activity of Xanthohumol and Its Non-Estrogenic Derivatives in Colon and Hepatocellular Carcinoma Cell Lines

(2019) Isabelle Logan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic Application of Micellar Solubilized Xanthohumol in a Western-Type Diet-Induced Mouse Model of Obesity, Diabetes and Non-Alcoholic Fatty Liver Disease

(2019) Mahli et al.   Cells

Xanthohumol Analogues as Potent Nrf2 Activators against Oxidative Stress Mediated Damages of PC12 Cells

(2019) Feifei Bai et al.   ACS Chemical Neuroscience

Pancreastatin inhibitor activates AMPK pathway via GRP78 and ameliorates dexamethasone induced fatty liver disease in C57BL/6 mice

(2019) Anand P. Gupta et al.   BIOMEDICINE & PHARMACOTHERAPY

Baicalein attenuates impairment of hepatic lysosomal acidification induced by high fat diet via maintaining V-ATPase assembly

(2019) Xinhong Zhu et al.   FOOD AND CHEMICAL TOXICOLOGY

Pancreastatin inhibitor, PSTi8 ameliorates metabolic health by modulating AKT/GSK-3β and PKCλ/ζ/SREBP1c pathways in high fat diet induced insulin resistance in peri-/post-menopausal rats

(2019) Guru R. Valicherla et al.   PEPTIDES

Improvements in Metabolic Syndrome by Xanthohumol Derivatives Are Linked to Altered Gut Microbiota and Bile Acid Metabolism

(2019) Yang Zhang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Imidacloprid-induced liver fibrosis in quails via activation of the TGF-β1/Smad pathway

(2019) Yueying Lv et al.   SCIENCE OF THE TOTAL ENVIRONMENT

AGE-RAGE axis blockade in diabetic nephropathy: Current status and future directions

(2018) Davoud Sanajou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Xanthohumol attenuates cisplatin-induced nephrotoxicity through inhibiting NF-κB and activating Nrf2 signaling pathways

(2018) Fan Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Protective effects of rutin on liver injury in type 2 diabetic db/db mice

(2018) Weishi Liang et al.   BIOMEDICINE & PHARMACOTHERAPY

Association of NAFLD With Diabetes and the Impact of BMI Changes: A 5-Year Cohort Study Based on 18,507 Elderly

(2017) Miao Liu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice

(2017) Raquel Costa et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Effect of Dietary Purified Xanthohumol from Hop (Humulus lupulus L.) Pomace on Adipose Tissue Mass, Fasting Blood Glucose Level, and Lipid Metabolism in KK-Ay Mice

(2017) Koki Takahashi et al.   Journal of Oleo Science

Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis

(2017) Anna M. Diehl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dietary Sugars and Endogenous Formation of Advanced Glycation Endproducts: Emerging Mechanisms of Disease

(2017) Manuela Aragno et al.   Nutrients

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Clinical Model for NASH and Advanced Fibrosis in Adult Patients With Diabetes and NAFLD: Guidelines for Referral in NAFLD

(2015) Jessica Bazick et al.   DIABETES CARE

The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels

(2015) Ralf Weiskirchen et al.   Frontiers in Physiology

Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops

(2014) Richard B. van Breemen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

An update on advanced glycation endproducts and atherosclerosis

(2012) Serena Del Turco et al.   BIOFACTORS

Role of Obesity and Lipotoxicity in the Development of Nonalcoholic Steatohepatitis: Pathophysiology and Clinical Implications

(2012) Kenneth Cusi   GASTROENTEROLOGY

Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration

(2011) LeeCole Legette et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Xanthohumol feeding does not impair organ function and homoeostasis in mice

(2010) Christoph Dorn et al.   FOOD AND CHEMICAL TOXICOLOGY

Identification of new phase II metabolites of xanthohumol in rat in vivo biotransformation of hop extracts using high-performance liquid chromatography electrospray ionization tandem mass spectrometry

(2010) Robert Jirásko et al.   JOURNAL OF CHROMATOGRAPHY A

Recovery and metabolism of xanthohumol in germ-free and human microbiota-associated rats

(2010) Laura Hanske et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis

(2010) Christoph Dorn et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis

(2009) Curtis K. Argo et al.   JOURNAL OF HEPATOLOGY

Modification of the cysteine residues in I B  kinase and NF- B (p65) by xanthohumol leads to suppression of NF- B-regulated gene products and potentiation of apoptosis in leukemia cells

(2008) K. B. Harikumar et al.   BLOOD