Defective mitophagy and synaptic degeneration in Alzheimer's disease: Focus on aging, mitochondria and synapse
出版年份 2021 全文链接
标题
Defective mitophagy and synaptic degeneration in Alzheimer's disease: Focus on aging, mitochondria and synapse
作者
关键词
Alzheimer's disease, Amyloid precursor protein, Amyloid beta, Autophagy, Mitophagy, Oxidative phosphorylation, Phosphorylated tau
出版物
FREE RADICAL BIOLOGY AND MEDICINE
Volume 172, Issue -, Pages 652-667
出版商
Elsevier BV
发表日期
2021-07-09
DOI
10.1016/j.freeradbiomed.2021.07.013
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Defective Autophagy and Mitophagy in Aging and Alzheimer’s Disease
- (2021) Michael Tran et al. Frontiers in Neuroscience
- Anti-brain Aging Effects of Small Molecule Inhibitor DDQ
- (2021) Murali Vijayan et al. MOLECULAR NEUROBIOLOGY
- Mendelian neurodegenerative disease genes involved in autophagy
- (2020) Eleanna Stamatakou et al. Cell Discovery
- Mitophagy regulates integrity of mitochondria at synapses and is critical for synaptic maintenance
- (2020) Sinsuk Han et al. EMBO REPORTS
- Defective mitophagy in Alzheimer’s disease
- (2020) Jangampalli Adi Pradeepkiran et al. AGEING RESEARCH REVIEWS
- Synaptic basis of Alzheimer’s disease: Focus on synaptic amyloid beta, P-tau and mitochondria
- (2020) Albin John et al. AGEING RESEARCH REVIEWS
- Mitochondrial DNA copy number is associated with cognitive impairment
- (2020) Shea J Andrews et al. Alzheimers & Dementia
- Structure Based Design and Molecular Docking Studies for Phosphorylated Tau Inhibitors in Alzheimer’s Disease
- (2019) Jangampalli Pradeepkiran et al. Cells
- Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
- (2019) D. Allan Butterfield et al. NATURE REVIEWS NEUROSCIENCE
- Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease
- (2019) Evandro F. Fang et al. NATURE NEUROSCIENCE
- Molecular Basis of Alzheimer’s Disease: Focus on Mitochondria
- (2019) Darryll M.A. Oliver et al. JOURNAL OF ALZHEIMERS DISEASE
- The Effectiveness of Vitamin E Treatment in Alzheimer’s Disease
- (2019) Ana Lloret et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Does intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein trigger early neurotoxicity in Alzheimer’s disease?
- (2019) I. Lauritzen et al. Current Alzheimer Research
- Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease
- (2019) P. Hemachandra Reddy et al. Cells
- Current Status of Healthy Aging and Dementia Research: A Symposium Summary
- (2019) P. Hemachandra Reddy et al. JOURNAL OF ALZHEIMERS DISEASE
- Synapse loss and progress of Alzheimer’s disease -A network model
- (2019) G. Kashyap et al. Scientific Reports
- Targeting Mitochondria in Alzheimer Disease: Rationale and Perspectives
- (2019) Chiara Lanzillotta et al. CNS DRUGS
- A mitochondrial delicacy: dynamin-related protein 1 and mitochondrial dynamics
- (2018) Mason T. Breitzig et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Mitochondrial membrane potential
- (2018) Ljubava D. Zorova et al. ANALYTICAL BIOCHEMISTRY
- Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer’s disease
- (2018) P Hemachandra Reddy et al. HUMAN MOLECULAR GENETICS
- Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer’s disease
- (2018) Maria Manczak et al. HUMAN MOLECULAR GENETICS
- Synergistic Protective Effects of Mitochondrial Division Inhibitor 1 and Mitochondria-Targeted Small Peptide SS31 in Alzheimer’s Disease
- (2018) P. Hemachandra Reddy et al. JOURNAL OF ALZHEIMERS DISEASE
- Abnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer's Disease
- (2018) Xiongwei Zhu et al. JOURNAL OF ALZHEIMERS DISEASE
- Redox Proteomics and Amyloid β-Peptide: Insights into Alzheimer Disease
- (2018) D Allan Butterfield et al. JOURNAL OF NEUROCHEMISTRY
- Pharmacophore-based models for therapeutic drugs against phosphorylated tau in Alzheimer’s disease
- (2018) Jangampalli Adi Pradeepkiran et al. DRUG DISCOVERY TODAY
- Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer’s disease
- (2017) P. Hemachandra Reddy et al. HUMAN MOLECULAR GENETICS
- Mitochondria-Division Inhibitor 1 Protects Against Amyloid-β induced Mitochondrial Fragmentation and Synaptic Damage in Alzheimer’s Disease
- (2017) P. Hemachandra Reddy et al. JOURNAL OF ALZHEIMERS DISEASE
- Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer’s disease Neurons
- (2017) Ravi Rajmohan et al. JOURNAL OF ALZHEIMERS DISEASE
- Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony
- (2017) Stefania Forner et al. TRENDS IN NEUROSCIENCES
- Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target
- (2017) Amadou K. S. Camara et al. Frontiers in Physiology
- Amyloid-β and Mitochondria in Aging and Alzheimer's Disease: Implications for Synaptic Damage and Cognitive Decline
- (2017) P. Hemachandra Reddy et al. JOURNAL OF ALZHEIMERS DISEASE
- Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons
- (2017) Maria Manczak et al. JOURNAL OF ALZHEIMERS DISEASE
- Alzheimer's Disease and the Amyloid-β Peptide
- (2017) M. Paul Murphy et al. JOURNAL OF ALZHEIMERS DISEASE
- Why Women Have More Alzheimer's Disease Than Men: Gender and Mitochondrial Toxicity of Amyloid-β Peptide
- (2017) Jose Viña et al. JOURNAL OF ALZHEIMERS DISEASE
- MIEF1/2 function as adaptors to recruit Drp1 to mitochondria and regulate the association of Drp1 with Mff
- (2017) Rong Yu et al. Scientific Reports
- Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology
- (2016) Inger Lauritzen et al. ACTA NEUROPATHOLOGICA
- Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis
- (2016) Ramesh Kandimalla et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Alzheimer's disease, menopause and the impact of the estrogenic environment
- (2016) A. Pines CLIMACTERIC
- Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease
- (2016) Xiangling Yin et al. HUMAN MOLECULAR GENETICS
- The genetic landscape of Alzheimer disease: clinical implications and perspectives
- (2015) Caroline Van Cauwenberghe et al. GENETICS IN MEDICINE
- Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease
- (2015) Maria Manczak et al. HUMAN MOLECULAR GENETICS
- Editorial (Thematic Issue: Mitochondrial Biogenesis: Pharmacological Approaches)
- (2014) Teresa Valero CURRENT PHARMACEUTICAL DESIGN
- First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics
- (2013) Hazel H Szeto BRITISH JOURNAL OF PHARMACOLOGY
- Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines
- (2013) D. F. Silva et al. HUMAN MOLECULAR GENETICS
- Sugar for the brain: the role of glucose in physiological and pathological brain function
- (2013) Philipp Mergenthaler et al. TRENDS IN NEUROSCIENCES
- The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update
- (2013) M. Alexeyev et al. Cold Spring Harbor Perspectives in Biology
- Cellular and molecular mechanisms of mitochondrial function
- (2012) Laura D. Osellame et al. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
- Is the mitochondrial outermembrane protein VDAC1 therapeutic target for Alzheimer's disease?
- (2012) P. Hemachandra Reddy BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization
- (2012) I. W. Hamley CHEMICAL REVIEWS
- Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage
- (2012) M. Manczak et al. HUMAN MOLECULAR GENETICS
- Assessment of newly synthesized mitochondrial DNA using BrdU labeling in primary neurons from Alzheimer's disease mice: Implications for impaired mitochondrial biogenesis and synaptic damage
- (2011) Marcus J. Calkins et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons
- (2011) Marcus J. Calkins et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics
- (2011) P. Hemachandra Reddy et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease
- (2011) P. Hemachandra Reddy BRAIN RESEARCH
- Mitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases
- (2011) P. H. Reddy et al. Current Alzheimer Research
- Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage
- (2011) Maria Manczak et al. HUMAN MOLECULAR GENETICS
- Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease
- (2011) M. J. Calkins et al. HUMAN MOLECULAR GENETICS
- Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage
- (2011) U. Shirendeb et al. HUMAN MOLECULAR GENETICS
- Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease
- (2011) U. P. Shirendeb et al. HUMAN MOLECULAR GENETICS
- Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease
- (2011) Baiyang Sheng et al. JOURNAL OF NEUROCHEMISTRY
- Alzheimer's disease: synapses gone cold
- (2011) Robert M Koffie et al. Molecular Neurodegeneration
- Alzheimer's Disease: Diagnosis and Treatment Across the Spectrum of Disease Severity
- (2011) Judith Neugroschl et al. MOUNT SINAI JOURNAL OF MEDICINE
- Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases
- (2010) P. Hemachandra Reddy et al. BRAIN RESEARCH REVIEWS
- Treatment of Alzheimer’s Disease with a Cholinesterase Inhibitor Combined with Antioxidants
- (2010) Umberto Cornelli Neurodegenerative Diseases
- Characteristics and Performance of a Modified Version of the ADCS-CGIC CIBIC+ for Mild Cognitive Impairment Clinical Trials
- (2009) Lon S. Schneider et al. ALZHEIMER DISEASE & ASSOCIATED DISORDERS
- Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease
- (2009) P. Hemachandra Reddy EXPERIMENTAL NEUROLOGY
- Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases
- (2009) H. Chen et al. HUMAN MOLECULAR GENETICS
- Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
- (2009) X. Wang et al. JOURNAL OF NEUROSCIENCE
- Donepezil delays progression to AD in MCI subjects with depressive symptoms
- (2009) P. H. Lu et al. NEUROLOGY
- Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
- (2008) Heng Du et al. NATURE MEDICINE
- Mitochondrial Medicine for Aging and Neurodegenerative Diseases
- (2008) P. Hemachandra Reddy NEUROMOLECULAR MEDICINE
- Amyloid- overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
- (2008) X. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease
- (2008) P. Hemachandra Reddy et al. TRENDS IN MOLECULAR MEDICINE
- Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging
- (2007) Grégoria Kalpouzos et al. NEUROBIOLOGY OF AGING
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started