Structure Based Design and Molecular Docking Studies for Phosphorylated Tau Inhibitors in Alzheimer’s Disease

Prediction models for dementia and neuropathology in the oldest old: the Vantaa 85+ cohort study

(2019) Anette Hall et al.   Alzheimers Research & Therapy

Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits

(2018) Ramon Velazquez et al.   AGING CELL

The Neurotoxic Role of Extracellular Tau Protein

(2018) Álvaro Sebastián-Serrano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Okadaic acid–induced tau hyperphosphorylation and the downregulation of Pin1 expression in primary cortical neurons

(2018) Derya Metin-Armağan et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Brain regional synchronous activity predicts tauopathy in 3×TgAD mice

(2018) Dong Liu et al.   NEUROBIOLOGY OF AGING

Tau protein aggregation is associated with cellular senescence in the brain

(2018) Nicolas Musi et al.   AGING CELL

Pharmacophore-based models for therapeutic drugs against phosphorylated tau in Alzheimer’s disease

(2018) Jangampalli Adi Pradeepkiran et al.   DRUG DISCOVERY TODAY

The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy

(2017) Alana N. Vagnozzi et al.   Translational Psychiatry

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase

(2016) Haoling Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primary Fibril Nucleation of Aggregation Prone Tau Fragments PHF6 and PHF6*

(2016) Florent X. Smit et al.   JOURNAL OF PHYSICAL CHEMISTRY B

3Drefine: an interactive web server for efficient protein structure refinement

(2016) Debswapna Bhattacharya et al.   NUCLEIC ACIDS RESEARCH

Role of computer-aided drug design in modern drug discovery

(2015) Stephani Joy Y. Macalino et al.   ARCHIVES OF PHARMACAL RESEARCH

FAF-Drugs3: a web server for compound property calculation and chemical library design

(2015) David Lagorce et al.   NUCLEIC ACIDS RESEARCH

Computational Approaches for Drug Discovery

(2014) Che-Lun Hung et al.   DRUG DEVELOPMENT RESEARCH

Tau Protein Modifications and Interactions: Their Role in Function and Dysfunction

(2014) Anna Mietelska-Porowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Global Analysis of Phosphorylation of Tau by the Checkpoint Kinases Chk1 and Chk2 in vitro

(2013) Jhoana Mendoza et al.   JOURNAL OF PROTEOME RESEARCH

CABS-flex: server for fast simulation of protein structure fluctuations

(2013) Michal Jamroz et al.   NUCLEIC ACIDS RESEARCH

lazar: a modular predictive toxicology framework

(2013) Andreas Maunz et al.   Frontiers in Pharmacology

Positional Effects of Phosphorylation on the Stability and Morphology of Tau-Related Amyloid Fibrils

(2012) Masafumi Inoue et al.   BIOCHEMISTRY

MDWeb and MDMoby: an integrated web-based platform for molecular dynamics simulations

(2012) Adam Hospital et al.   BIOINFORMATICS

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

To milliseconds and beyond: challenges in the simulation of protein folding

(2012) Thomas J Lane et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties

(2012) Feixiong Cheng et al.   Journal of Chemical Information and Modeling

Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1

(2012) Kanae Iijima-Ando et al.   PLoS Genetics

The future of Alzheimer's disease: The next 10 years

(2011) Harald Hampel et al.   PROGRESS IN NEUROBIOLOGY

fpocket: online tools for protein ensemble pocket detection and tracking

(2010) P. Schmidtke et al.   NUCLEIC ACIDS RESEARCH

Medicinal Chemistry and the Molecular Operating Environment (MOE): Application of QSAR and Molecular Docking to Drug Discovery

(2008) Santiago Vilar et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY