Inhibition of IRAK1 Ubiquitination Determines Glucocorticoid Sensitivity for TLR9-Induced Inflammation in Macrophages

Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use

(2016) Jing Sun et al.   Science Signaling

Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use

(2016) Jing Sun et al.   Science Signaling

Transforming growth factor-β-activated kinase 1 resistance limits glucocorticoid responsiveness to Toll-like receptor 4-mediated inflammation

(2015) Fansheng Kong et al.   IMMUNOLOGY

IL-1 Receptor-Associated Kinase Signaling and Its Role in Inflammation, Cancer Progression, and Therapy Resistance

(2014) Ajay Jain et al.   Frontiers in Immunology

Targeting IRAK1 as a Therapeutic Approach for Myelodysplastic Syndrome

(2013) Garrett W. Rhyasen et al.   CANCER CELL

IRAK1-Dependent Signaling Mediates Mortality in Polymicrobial Sepsis

(2013) Rachna Chandra et al.   INFLAMMATION

Genomic and non-genomic effects of glucocorticoids on allergic rhinitis model in mice

(2013) Eriko Kusaka et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mechanisms of the anti-inflammatory effects of glucocorticoids: genomic and nongenomic interference with MAPK signaling pathways

(2012) Emira Ayroldi et al.   FASEB JOURNAL

 -TrCP-Mediated IRAK1 Degradation Releases TAK1-TRAF6 from the Membrane to the Cytosol for TAK1-Dependent NF- B Activation

(2012) W. Cui et al.   MOLECULAR AND CELLULAR BIOLOGY

Non-genomic effect of glucocorticoids on cardiovascular system

(2012) Sung Ryul Lee et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Glucocorticoids inhibit dendritic cell maturation induced by Toll-like receptor 7 and Toll-like receptor 8

(2011) Alexandre Larangé et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Genomic and non-genomic actions of glucocorticoids in asthma

(2010) AbdullahA Alangari   Annals of Thoracic Medicine

TAK1 targeting by glucocorticoids determines JNK and I B regulation in Toll-like receptor-stimulated macrophages

(2010) S. Bhattacharyya et al.   BLOOD

TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

(2010) Cristiana Guiducci et al.   NATURE

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

(2009) Ping-Hui Tseng et al.   NATURE IMMUNOLOGY

Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus

(2009) C. O. Jacob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pellino 3b Negatively Regulates Interleukin-1-induced TAK1-dependent NFκB Activation

(2008) Hui Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lys63-Linked Polyubiquitination of IRAK-1 Is Required for Interleukin-1 Receptor- and Toll-Like Receptor-Mediated NF- B Activation

(2008) D. B. Conze et al.   MOLECULAR AND CELLULAR BIOLOGY

Interleukin-1 (IL-1) Induces the Lys63-Linked Polyubiquitination of IL-1 Receptor-Associated Kinase 1 To Facilitate NEMO Binding and the Activation of I B  Kinase

(2008) M. Windheim et al.   MOLECULAR AND CELLULAR BIOLOGY

Genomic and nongenomic effects of glucocorticoids

(2008) Cindy Stahn et al.   Nature clinical practice. Rheumatology