Journal
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
Volume 18, Issue -, Pages 1330-1341Publisher
ELSEVIER
DOI: 10.1016/j.csbj.2020.05.018
Keywords
ChIP-seq; RNA-seq; NGS; Data integration; Multi-omics; Transcriptional regulation
Funding
- ERC StG SILENCE [638573]
- Helmholtz Association ICEMED
- European Research Council (ERC) [638573] Funding Source: European Research Council (ERC)
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Advancements in the field of next generation sequencing lead to the generation of ever-more data, with the challenge often being how to combine and reconcile results from different OMICs studies such as genome, epigenome and transcriptome. Here we provide an overview of the standard processing pipelines for ChIP-seq and RNA-seq as well as common downstream analyses. We describe popular multi-omics data integration approaches used to identify target genes and co-factors, and we discuss how machine learning techniques may predict transcriptional regulators and gene expression. (C) 2020 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
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