Strategies to neutralize RhoA/ROCK pathway after spinal cord injury

Elevated TRPV4 Levels Contribute to Endothelial Damage and Scarring in Experimental Spinal Cord Injury

(2020) Hemant Kumar et al.   JOURNAL OF NEUROSCIENCE

RhoA-ROCK Signaling as a Therapeutic Target in Traumatic Brain Injury

(2020) Shalaka Mulherkar et al.   Cells

Olig2-Induced Semaphorin Expression Drives Corticospinal Axon Retraction After Spinal Cord Injury

(2020) Masaki Ueno et al.   CEREBRAL CORTEX

Axon Growth of CNS Neurons in Three Dimensions Is Amoeboid and Independent of Adhesions

(2020) Telma E. Santos et al.   Cell Reports

Combined Treatment with Fasudil and Menthol Improves Functional Recovery in Rat Spinal Cord Injury Model

(2020) JeongHoon Kim et al.   Biomedicines

Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury

(2020) Di Wu et al.   Nature Communications

ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS

(2019) Andrea Tedeschi et al.   NEURON

Regenerative Therapy for Spinal Cord Injury

(2019) Nureddin Ashammakhi et al.   TISSUE ENGINEERING PART B-REVIEWS

RhoA Controls Axon Extension Independent of Specification in the Developing Brain

(2019) Sebastian Dupraz et al.   CURRENT BIOLOGY

Moving beyond the glial scar for spinal cord repair

(2019) Elizabeth J. Bradbury et al.   Nature Communications

Cytoskeleton dynamics in axon regeneration

(2018) Oriane Blanquie et al.   CURRENT OPINION IN NEUROBIOLOGY

Systemic epothilone D improves hindlimb function after spinal cord contusion injury in rats

(2018) Beatrice Sandner et al.   EXPERIMENTAL NEUROLOGY

Systemic administration of epothilone D improves functional recovery of walking after rat spinal cord contusion injury

(2018) Jörg Ruschel et al.   EXPERIMENTAL NEUROLOGY

Dissecting spinal cord regeneration

(2018) Michael V. Sofroniew   NATURE

ROCK inhibition in models of neurodegeneration and its potential for clinical translation

(2018) Jan Christoph Koch et al.   PHARMACOLOGY & THERAPEUTICS

Neutrophil elastase inhibition effectively rescued angiopoietin-1 decrease and inhibits glial scar after spinal cord injury

(2018) Hemant Kumar et al.   Acta Neuropathologica Communications

The Microtubule-Associated Protein Tau Mediates the Organization of Microtubules and Their Dynamic Exploration of Actin-Rich Lamellipodia and Filopodia of Cortical Growth Cones

(2017) Sayantanee Biswas et al.   JOURNAL OF NEUROSCIENCE

The diversity and disparity of the glial scar

(2017) Katrina L. Adams et al.   NATURE NEUROSCIENCE

The Role of Netrin-1 in Improving Functional Recovery through Autophagy Stimulation Following Spinal Cord Injury in Rats

(2017) Liangjie Bai et al.   Frontiers in Cellular Neuroscience

Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-κB-dependent neuroinflammation to improve functional recovery after spinal cord injury

(2017) Jian Chen et al.   Cell Death & Disease

RGMa inhibition with human monoclonal antibodies promotes regeneration, plasticity and repair, and attenuates neuropathic pain after spinal cord injury

(2017) Andrea J. Mothe et al.   Scientific Reports

Neurite elongation is highly correlated with bulk forward translocation of microtubules

(2017) Ahmad I. M. Athamneh et al.   Scientific Reports

ROCK inhibition with fasudil promotes early functional recovery of spinal cord injury in rats by enhancing microglia phagocytosis

(2016) Pei-cai Fu et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Propitious Therapeutic Modulators to Prevent Blood-Spinal Cord Barrier Disruption in Spinal Cord Injury

(2016) Hemant Kumar et al.   MOLECULAR NEUROBIOLOGY

Regulating Rho GTPases and their regulators

(2016) Richard G. Hodge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury

(2016) Miao He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the NG2 Glial Scar after Spinal Cord Injury

(2016) Amber R. Hackett et al.   Frontiers in Neurology

The therapeutic effects of Rho-ROCK inhibitors on CNS disorders

(2016) Takekazu Kubo   Therapeutics and Clinical Risk Management

Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury

(2015) Y. Zou et al.   JOURNAL OF NEUROSCIENCE

Systemic administration of epothilone B promotes axon regeneration after spinal cord injury

(2015) J. Ruschel et al.   SCIENCE

Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury

(2014) Bradley T. Lang et al.   NATURE

CNS axon regeneration inhibitors stimulate an immediate early gene response via MAP kinase-SRF signaling

(2014) Sina Stern et al.   Molecular Brain

Chondroitin Sulfate Proteoglycans in the Nervous System: Inhibitors to Repair

(2014) Justin R. Siebert et al.   Biomed Research International

Axon growth inhibition by RhoA/ROCK in the central nervous system

(2014) Yuki Fujita et al.   Frontiers in Neuroscience

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

Drosophila Growth Cones Advance by Forward Translocation of the Neuronal Cytoskeletal Meshwork In Vivo

(2013) Douglas H. Roossien et al.   PLoS One

Rho-ROCK Inhibition in the Treatment of Spinal Cord Injury

(2013) Nicole Forgione et al.   World Neurosurgery

SKI-1 and Furin Generate Multiple RGMa Fragments that Regulate Axonal Growth

(2012) Nardos G. Tassew et al.   DEVELOPMENTAL CELL

Scar-mediated inhibition and CSPG receptors in the CNS

(2012) Kartavya Sharma et al.   EXPERIMENTAL NEUROLOGY

NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans

(2012) Travis L Dickendesher et al.   NATURE NEUROSCIENCE

ADF/Cofilin-Mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain

(2012) Kevin C. Flynn et al.   NEURON

Leukocyte Common Antigen-Related Phosphatase Is a Functional Receptor for Chondroitin Sulfate Proteoglycan Axon Growth Inhibitors

(2011) D. Fisher et al.   JOURNAL OF NEUROSCIENCE

Taxol Facilitates Axon Regeneration in the Mature CNS

(2011) V. Sengottuvel et al.   JOURNAL OF NEUROSCIENCE

Signaling Pathways in Reactive Astrocytes, a Genetic Perspective

(2011) Wenfei Kang et al.   MOLECULAR NEUROBIOLOGY

PDE 7 Inhibitors: New Potential Drugs for the Therapy of Spinal Cord Injury

(2011) Irene Paterniti et al.   PLoS One

Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury

(2011) F. Hellal et al.   SCIENCE

Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity

(2010) Mutsuki Amano et al.   Cytoskeleton

Functions of Nogo proteins and their receptors in the nervous system

(2010) Martin E. Schwab   NATURE REVIEWS NEUROSCIENCE

NG2 and phosphacan are present in the astroglial scar after human traumatic spinal cord injury

(2009) Armin Buss et al.   BMC Neurology

SOCS3 Deletion Promotes Optic Nerve Regeneration In Vivo

(2009) Patrice D. Smith et al.   NEURON

PTP  Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration

(2009) Y. Shen et al.   SCIENCE

KLF Family Members Regulate Intrinsic Axon Regeneration Ability

(2009) D. L. Moore et al.   SCIENCE

Spinal cord injury: Emerging beneficial role of reactive astrocytes’ migration

(2008) Francois Renault-Mihara et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Microtubule stabilization specifies initial neuronal polarization

(2008) Harald Witte et al.   JOURNAL OF CELL BIOLOGY

Local Inhibition of Rho Signaling by Cell-Permeable Recombinant Protein BA-210 Prevents Secondary Damage and Promotes Functional Recovery following Acute Spinal Cord Injury

(2008) Stephanie Lord-Fontaine et al.   JOURNAL OF NEUROTRAUMA

Assessment of functional recovery and axonal sprouting in oligodendrocyte-myelin glycoprotein (OMgp) null mice after spinal cord injury

(2008) Benxiu Ji et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

PirB is a Functional Receptor for Myelin Inhibitors of Axonal Regeneration

(2008) J. K. Atwal et al.   SCIENCE

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE