Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2/HO-1 pathway

Transport mechanism and subcellular localization of a polysaccharide from Cucurbia Moschata across Caco-2 cells model

(2021) Fei Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Synergistic protection of astragalus polysaccharides and matrine against ulcerative colitis and associated lung injury in rats

(2020) Xin Yan et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis

(2020) Minyi Xu et al.   Cell Death & Disease

Ferroptosis as an emerging target in inflammatory diseases

(2020) Huimin Mao et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease

(2020) Lisa Mayr et al.   Nature Communications

A Review of the Pharmacological Action of Astragalus Polysaccharide

(2020) Yijun Zheng et al.   Frontiers in Pharmacology

Efficiency of Traditional Chinese medicine targeting the Nrf2/HO-1 signaling pathway

(2020) Bin Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell

(2020) Tao Bai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Astragalus polysaccharide alleviates cognitive impairment and β-amyloid accumulation in APP/PS1 mice via Nrf2 pathway

(2020) Xiude Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The gut microbiota alteration and the key bacteria in Astragalus polysaccharides (APS)-improved osteoporosis

(2020) Junsheng Liu et al.   FOOD RESEARCH INTERNATIONAL

Ferroptosis mediated DSS-induced ulcerative colitis associated with Nrf2/HO-1 signaling pathway

(2020) Yeru Chen et al.   IMMUNOLOGY LETTERS

Curculigoside inhibits ferroptosis in ulcerative colitis through the induction of GPX4

(2020) Shujun Wang et al.   LIFE SCIENCES

Reprogrammed Epigenetic Landscape-Prophesied Functions of Bioactive Polysaccharides in Alleviating Diseases: A Pilot Study of DNA Methylome Remodeling in Astragalus Polysaccharide (APS)-Improved Osteoporosis in a Rat Model

(2020) Junsheng Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Astragalus Polysaccharide RAP Selectively Attenuates Paclitaxel-Induced Cytotoxicity Toward RAW 264.7 Cells by Reversing Cell Cycle Arrest and Apoptosis

(2019) Wan-Rong Bao et al.   Frontiers in Pharmacology

A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis

(2019) Eduardo P. Amaral et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proteolytic, lipidergic and polysaccharide molecular recognition shape innate responses to house dust mite allergens

(2019) Alain Jacquet et al.   ALLERGY

Astragalus polysaccharides alleviate tilmicosin-induced toxicity in rats by inhibiting oxidative damage and modulating the expressions of HSP70, NF-kB and Nrf2/HO-1 pathway

(2019) Mayada Ragab Farag et al.   RESEARCH IN VETERINARY SCIENCE

Repair Effects of Astragalus Polysaccharides with Different Molecular Weights on Oxidatively Damaged HK-2 Cells

(2019) Jin Han et al.   Scientific Reports

Astragalus polysaccharide alleviates H2O2-triggered oxidative injury in human umbilical vein endothelial cells via promoting KLF2

(2019) Dongtao Li et al.   Artificial Cells Nanomedicine and Biotechnology

Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation

(2019) Wenfang Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Astragalus polysaccharides (PG2) Enhances the M1 Polarization of Macrophages, Functional Maturation of Dendritic Cells, and T Cell-Mediated Anticancer Immune Responses in Patients with Lung Cancer

(2019) Oluwaseun Adebayo Bamodu et al.   Nutrients

Genipin attenuates dextran sulfate sodium-induced colitis via suppressing inflammatory and oxidative responses

(2019) Zhiguo Li et al.   INFLAMMOPHARMACOLOGY

Heme oxygenase-1 mediates BAY 11–7085 induced ferroptosis

(2018) Ling-Chu Chang et al.   CANCER LETTERS

Metabolomics Research Reveals the Mechanism of Action of Astragalus Polysaccharide in Rats with Digestive System Disorders

(2018) Huanjun Wang et al.   MOLECULES

Astragalus polysaccharide from Astragalus Melittin ameliorates inflammation via suppressing the activation of TLR-4/NF-κB p65 signal pathway and protects mice from CVB3-induced virus myocarditis

(2018) Tianlong Liu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Astragalus polysaccharides protect against dextran sulfate sodium-induced colitis by inhibiting NF-κВ activation

(2017) Jun Lv et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Ulcerative colitis

(2017) Ryan Ungaro et al.   LANCET

Astragalus polysaccharides attenuate PCV2 infection by inhibiting endoplasmic reticulum stress in vivo and in vitro

(2017) Hongxia Xue et al.   Scientific Reports

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

(2016) Agnieszka Loboda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inflammatory bowel disease

(2016) Richard Hodson   NATURE

Astagalus Polysaccharide Attenuates Murine Colitis through Inhibiton of the NLRP3 Inflammasome

(2016) Zhiqiang Tian et al.   PLANTA MEDICA

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

(2015) Mai Matsushita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Effect of Astragalus polysaccharides on expression of TNF-α, IL-1β and NFATc4 in a rat model of experimental colitis

(2014) Min Yang et al.   CYTOKINE

Inflammatory Bowel Disease: Mechanisms, Redox Considerations, and Therapeutic Targets

(2013) Fiorella Biasi et al.   ANTIOXIDANTS & REDOX SIGNALING

Chemical and biological assessment of Angelica herbal decoction: Comparison of different preparations during historical applications

(2012) Wendy Li Zhang et al.   PHYTOMEDICINE