Nuclear receptor Nur77: its role in chronic inflammatory diseases

Dynamic role of macrophage CX3CR1 expression in inflammatory bowel disease

(2021) Junyi Li et al.   IMMUNOLOGY LETTERS

The changing landscape of atherosclerosis

(2021) Peter Libby   NATURE

Orphan nuclear receptor 4A1 (NR4A1) and novel ligands

(2021) Stephen Safe et al.   Essays in Biochemistry

Targeting immunometabolism as an anti-inflammatory strategy

(2020) Eva M. Pålsson-McDermott et al.   CELL RESEARCH

Reactivation of NR4A1 Restrains Chondrocyte Inflammation and Ameliorates Osteoarthritis in Rats

(2020) Yan Xiong et al.   Frontiers in Cell and Developmental Biology

‘Nur'turing tumor T cell tolerance and exhaustion: novel function for Nuclear Receptor Nur77 in immunity

(2020) Sanne C. Lith et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

GPA Peptide-Induced Nur77 Localization at Mitochondria Inhibits Inflammation and Oxidative Stress through Activating Autophagy in the Intestine

(2020) Zhao Deng et al.   Oxidative Medicine and Cellular Longevity

NR4A transcription factors limit CAR T cell function in solid tumours

(2019) Joyce Chen et al.   NATURE

Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction

(2019) Xindong Liu et al.   NATURE

Differential Pathogenic Th17 Profile in Mesenteric Lymph Nodes of Crohn's Disease and Ulcerative Colitis Patients

(2019) Marwa Bsat et al.   Frontiers in Immunology

Molecular, Chemical, and Structural Characterization of Prostaglandin A2 as a Novel Agonist for Nur77

(2019) Sowmya P Lakshmi et al.   BIOCHEMICAL JOURNAL

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis

(2019) Judith F. Ashouri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unraveling the Complex Interplay Between T Cell Metabolism and Function

(2018) Ramon I. Klein Geltink et al.   Annual Review of Immunology

Nr4a1 plays a crucial modulatory role in Th1/Th17 cell responses and CNS autoimmunity

(2018) Li-Mei Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

Nur77 serves as a molecular brake of the metabolic switch during T cell activation to restrict autoimmunity

(2018) Marie Liebmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism

(2018) Duco Steven Koenis et al.   Cell Reports

Nuclear Receptor 77

(2018) Asoka Banno et al.   AMERICAN JOURNAL OF PATHOLOGY

Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy

(2017) Mengjie Hu et al.   MOLECULAR CELL

Macrophage Immunometabolism: Where Are We (Going)?

(2017) Jan Van den Bossche et al.   TRENDS IN IMMUNOLOGY

Nur77-deficiency in bone marrow-derived macrophages modulates inflammatory responses, extracellular matrix homeostasis, phagocytosis and tolerance

(2016) Anouk A. J. Hamers et al.   BMC GENOMICS

Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6C low Monocytes while Preserving Macrophage Gene Function

(2016) Graham D. Thomas et al.   IMMUNITY

Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice

(2016) Xiu-Ming Li et al.   Journal of Inflammation-London

NUR77 exerts a protective effect against inflammatory bowel disease by negatively regulating the TRAF6/TLR-IL-1R signalling axis

(2015) Hua Wu et al.   JOURNAL OF PATHOLOGY

Role of the innate and adaptive immune responses in the course of multiple sclerosis

(2015) Bernhard Hemmer et al.   LANCET NEUROLOGY

Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation

(2015) Li Li et al.   Nature Chemical Biology

Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation

(2015) Iftach Shaked et al.   NATURE IMMUNOLOGY

Deficiency of Nuclear Receptor Nur77 Aggravates Mouse Experimental Colitis by Increased NFκB Activity in Macrophages

(2015) Anouk A. J. Hamers et al.   PLoS One

Nur77 Decreases Atherosclerosis Progression in apoE−/− Mice Fed a High-Fat/High-Cholesterol Diet

(2014) Yan-Wei Hu et al.   PLoS One

NR4A nuclear receptors in immunity and atherosclerosis

(2013) Anouk A.J. Hamers et al.   CURRENT OPINION IN LIPIDOLOGY

Limited Role of Nuclear Receptor Nur77 in Escherichia coli-Induced Peritonitis

(2013) Anouk A. J. Hamers et al.   INFECTION AND IMMUNITY

Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice

(2013) Lily C. Chao et al.   JOURNAL OF LIPID RESEARCH

Bone Marrow–Specific Deficiency of Nuclear Receptor Nur77 Enhances Atherosclerosis

(2011) Anouk A.J. Hamers et al.   CIRCULATION RESEARCH

NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis

(2011) Richard N. Hanna et al.   CIRCULATION RESEARCH

Discovery of a Protein–Metabolite Interaction between Unsaturated Fatty Acids and the Nuclear Receptor Nur77 Using a Metabolomics Approach

(2011) Nawaporn Vinayavekhin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of the multiple sclerosis traits: Nuclear receptors (NR) impaired apoptosis pathway and the role of 1-alpha 25-dihydroxyvitamin D3

(2011) Anat Achiron et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes

(2011) Richard N Hanna et al.   NATURE IMMUNOLOGY

Nuclear receptor Nur77 suppresses inflammatory response dependent on COX-2 in macrophages induced by oxLDL

(2010) Qin Shao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Microarray analysis identifies altered regulation of nuclear receptor family members in the pre-disease state of multiple sclerosis

(2010) Anat Achiron et al.   NEUROBIOLOGY OF DISEASE

During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain

(2008) Jennifer Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cytosporone B is an agonist for nuclear orphan receptor Nur77

(2008) Yanyan Zhan et al.   Nature Chemical Biology