Dynamic role of macrophage CX3CR1 expression in inflammatory bowel disease

Dissecting the Heterogeneity in T-Cell Mediated Inflammation in IBD

(2020) Irma Tindemans et al.   Cells

Blockade of the Fractalkine–CX3CR1 Axis Ameliorates Experimental Colitis by Dislodging Venous Crawling Monocytes

(2019) Yoshikazu Kuboi et al.   INTERNATIONAL IMMUNOLOGY

ILC3 function as a double-edged sword in inflammatory bowel diseases

(2019) Boning Zeng et al.   Cell Death & Disease

Differential Pathogenic Th17 Profile in Mesenteric Lymph Nodes of Crohn's Disease and Ulcerative Colitis Patients

(2019) Marwa Bsat et al.   Frontiers in Immunology

IL-23–producing IL-10Rα–deficient gut macrophages elicit an IL-22–driven proinflammatory epithelial cell response

(2019) Biana Bernshtein et al.   Science Immunology

Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis

(2019) Cristina Godinho-Silva et al.   NATURE

Inhibition of the LncRNA Gpr19 attenuates ischemia‐reperfusion injury after acute myocardial infarction by inhibiting apoptosis and oxidative stress via the miR‐324‐5p/Mtfr1 axis

(2019) Liu Huang et al.   IUBMB LIFE

A Multiorgan Trafficking Circuit Provides Purifying Selection of Listeria monocytogenes Virulence Genes

(2019) Alexander Louie et al.   mBio

CX3CL1/CX3CR1 Axis, as the Therapeutic Potential in Renal Diseases: Friend or Foe?

(2018) Quan Zhuang et al.   CURRENT GENE THERAPY

Diet Modifies Colonic Microbiota and CD4 + T Cell Repertoire to Induce Flares of Colitis in Mice With Myeloid-cell Expression of Interleukin 23

(2018) Lili Chen et al.   GASTROENTEROLOGY

Th17 plasticity and its relevance to inflammatory bowel disease

(2018) Aito Ueno et al.   JOURNAL OF AUTOIMMUNITY

Human intestinal pro-inflammatory CD11chighCCR2+CX3CR1+ macrophages, but not their tolerogenic CD11c−CCR2−CX3CR1− counterparts, are expanded in inflammatory bowel disease

(2018) D. Bernardo et al.   Mucosal Immunology

Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization

(2018) Sujin Kang et al.   NATURE IMMUNOLOGY

CX3CR1+mononuclear phagocytes control immunity to intestinal fungi

(2018) Irina Leonardi et al.   SCIENCE

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

(2018) Manuel A. Rivas et al.   PLoS Genetics

LAG3+ Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis

(2018) David Bauché et al.   IMMUNITY

Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis

(2018) Jim G. Castellanos et al.   IMMUNITY

Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches

(2017) R. Balfour Sartor et al.   GASTROENTEROLOGY

Non-redundant role of the chemokine receptor CX3CR1 in the anti-inflammatory function of gut macrophages

(2017) G. Marelli et al.   IMMUNOBIOLOGY

E6130, a Novel CX3C Chemokine Receptor 1 (CX3CR1) Modulator, Attenuates Mucosal Inflammation and Reduces CX3CR1 + Leukocyte Trafficking in Mice with Colitis

(2017) Hisashi Wakita et al.   MOLECULAR PHARMACOLOGY

Gut permeability and mucosal inflammation: bad, good or context dependent

(2017) R Ahmad et al.   Mucosal Immunology

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

(2017) Deepak A. Rao et al.   NATURE

Chemically induced mouse models of acute and chronic intestinal inflammation

(2017) Stefan Wirtz et al.   Nature Protocols

Granulocyte-colony–stimulating factor (G-CSF) signaling in spinal microglia drives visceral sensitization following colitis

(2017) Lilian Basso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenesis of Inflammatory Bowel Disease and Recent Advances in Biologic Therapies

(2017) Duk Hwan Kim et al.   Immune Network

Krüppel-like factor KLF10 deficiency predisposes to colitis through colonic macrophage dysregulation

(2015) Konstantinos A. Papadakis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Enhanced Levels of Chemokines and Their Receptors in the Colon of Microscopic Colitis Patients Indicate Mixed Immune Cell Recruitment

(2015) Sezin Günaltay et al.   MEDIATORS OF INFLAMMATION

Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses

(2015) Casandra Panea et al.   Cell Reports

MicroRNA-223 Regulates the Differentiation and Function of Intestinal Dendritic Cells and Macrophages by Targeting C/EBPβ

(2015) Haibo Zhou et al.   Cell Reports

Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis

(2014) Ehud Zigmond et al.   IMMUNITY

Macrophages derived from infiltrating monocytes mediate autoimmune myelin destruction

(2014) Michael T. Heneka   JOURNAL OF EXPERIMENTAL MEDICINE

Critical role for CX3CR1+mononuclear phagocytes in intestinal homeostasis

(2014) Giorgio Trinchieri   JOURNAL OF EXPERIMENTAL MEDICINE

CX3CR1+mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22

(2014) Randy S. Longman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Essential Involvement of CX3CR1-Mediated Signals in the Bactericidal Host Defense during Septic Peritonitis

(2014) Y. Ishida et al.   JOURNAL OF IMMUNOLOGY

Decreased Expression of the Fractalkine Receptor CX3CR1 on Circulating Monocytes as New Feature of Sepsis-Induced Immunosuppression

(2014) Alexandre Pachot et al.   JOURNAL OF IMMUNOLOGY

Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis

(2014) A. Mortha et al.   SCIENCE

CD47 fusion protein targets CD172a+cells in Crohn’s disease and dampens the production of IL-1β and TNF

(2013) Nobuyasu Baba et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CX3CR1+ cells facilitate the activation of CD4 T cells in the colonic lamina propria during antigen-driven colitis

(2013) V Rossini et al.   Mucosal Immunology

Inflammation switches the differentiation program of Ly6Chimonocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon

(2012) Aymeric Rivollier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors

(2012) C C Bain et al.   Mucosal Immunology

Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis

(2012) H. Kayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CX3CR1 defines functionally distinct intestinal mononuclear phagocyte subsets which maintain their respective functions during homeostatic and inflammatory conditions

(2011) Benjamin Weber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Increased production of soluble TLR2 by lamina propria mononuclear cells from ulcerative colitis patients

(2011) Enzo Candia et al.   IMMUNOBIOLOGY

CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice

(2011) Oscar Medina-Contreras et al.   JOURNAL OF CLINICAL INVESTIGATION

Intestinal Epithelial Cell-Derived Semaphorin 7A Negatively Regulates Development of Colitis via  v 1 Integrin

(2011) S. Kang et al.   JOURNAL OF IMMUNOLOGY

Targeting leukocyte migration and adhesion in Crohn’s disease and ulcerative colitis

(2011) Saskia Thomas et al.   INFLAMMOPHARMACOLOGY

Enteric Flora Expands Gut Lamina Propria CX 3 CR1 + Dendritic Cells Supporting Inflammatory Immune Responses under Normal and Inflammatory Conditions

(2010) Jan Hendrik Niess et al.   JOURNAL OF IMMUNOLOGY

Crucial involvement of the CX3CR1-CX3CL1 axis in dextran sulfate sodium-mediated acute colitis in mice

(2010) Feodora I. Kostadinova et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Chemokines as Novel Therapeutic Targets for Inflammatory Bowel Disease

(2009) Miyuki Nishimura et al.   Annals of the New York Academy of Sciences