Novel DNA methylation loci and genes showing pleiotropic association with Alzheimer’s dementia: a network Mendelian randomization analysis

Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology

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The multiplex model of the genetics of Alzheimer’s disease

(2020) Rebecca Sims et al.   NATURE NEUROSCIENCE

Mendelian randomization integrating GWAS and mQTL data identified novel pleiotropic DNA methylation loci for neuropathology of Alzheimer’s disease

(2020) Di Liu et al.   NEUROBIOLOGY OF AGING

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Ndufs2, A Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction

(2019) Kimberly J Dunham-Snary et al.   CIRCULATION RESEARCH

Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s disease

(2019) Stephen A. Semick et al.   ACTA NEUROPATHOLOGICA

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Diabetes drugs in the fight against Alzheimer's disease

(2019) Virginia Boccardi et al.   AGEING RESEARCH REVIEWS

Association of Lifestyle and Genetic Risk With Incidence of Dementia

(2019) Ilianna Lourida et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A methylation study of long-term depression risk

(2019) Shaunna L. Clark et al.   MOLECULAR PSYCHIATRY

Individual and joint performance of DNA methylation profiles, genetic risk score and environmental risk scores for predicting breast cancer risk

(2019) Zhong Guan et al.   Molecular Oncology

Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease

(2019) Tianxiao Huan et al.   Nature Communications

Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease

(2018) Tom G Richardson et al.   HUMAN MOLECULAR GENETICS

Whole-exome sequencing of the BDR cohort: evidence to support the role of the PILRA gene in Alzheimer's disease

(2018) T. Patel et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits

(2018) Yang Wu et al.   Nature Communications

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

(2018) Ting Qi et al.   Nature Communications

GWAS on family history of Alzheimer’s disease

(2018) Riccardo E. Marioni et al.   Translational Psychiatry

Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study

(2018) Katerina Trajanoska et al.   BMJ-British Medical Journal

Leveraging DNA-Methylation Quantitative-Trait Loci to Characterize the Relationship between Methylomic Variation, Gene Expression, and Complex Traits

(2018) Eilis Hannon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

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Identification of 55,000 Replicated DNA Methylation QTL

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Mutual effect of cerebral amyloid β and peripheral lymphocytes in cognitively normal older individuals

(2017) Fumihiko Yasuno et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Associations between specific autoimmune diseases and subsequent dementia: retrospective record-linkage cohort study, UK

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Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

(2017) Bernard Ng et al.   NATURE NEUROSCIENCE

MethBank 3.0: a database of DNA methylomes across a variety of species

(2017) Rujiao Li et al.   NUCLEIC ACIDS RESEARCH

Parkinson's disease susceptibility variants and severity of Lewy body pathology

(2017) Michael G. Heckman et al.   PARKINSONISM & RELATED DISORDERS

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score

(2017) Rahul S. Desikan et al.   PLOS MEDICINE

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Homozygous FIBP nonsense variant responsible of syndromic overgrowth, with overgrowth, macrocephaly, retinal coloboma and learning disabilities

(2016) C. Thauvin-Robinet et al.   CLINICAL GENETICS

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Gene expression elucidates functional impact of polygenic risk for schizophrenia

(2016) Menachem Fromer et al.   NATURE NEUROSCIENCE

Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex

(2015) Andrew E Jaffe et al.   NATURE NEUROSCIENCE

Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci

(2015) Eilis Hannon et al.   NATURE NEUROSCIENCE

Aging of blood can be tracked by DNA methylation changes at just three CpG sites

(2014) Carola Weidner et al.   GENOME BIOLOGY

The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts

(2014) James R Wagner et al.   GENOME BIOLOGY

Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements

(2013) Elin Grundberg et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Histone post-translational modifications regulate autophagy flux and outcome

(2013) Jens Füllgrabe et al.   Autophagy

Cross-sectional and longitudinal changes in DNA methylation with age: an epigenome-wide analysis revealing over 60 novel age-associated CpG sites

(2013) I. Florath et al.   HUMAN MOLECULAR GENETICS

Defective FGF signaling causes coloboma formation and disrupts retinal neurogenesis

(2012) Shuyi Chen et al.   CELL RESEARCH

Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila

(2012) Dickon M. Humphrey et al.   HUMAN MOLECULAR GENETICS

Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation

(2012) Jing Wang et al.   NATURE IMMUNOLOGY

The Brisbane Systems Genetics Study: Genetical Genomics Meets Complex Trait Genetics

(2012) Joseph E. Powell et al.   PLoS One

Mutations in BCKD-kinase Lead to a Potentially Treatable Form of Autism with Epilepsy

(2012) G. Novarino et al.   SCIENCE

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Alzheimer’s disease is not “brain aging”: neuropathological, genetic, and epidemiological human studies

(2011) Peter T. Nelson et al.   ACTA NEUROPATHOLOGICA

Cohort Profile: The Lothian Birth Cohorts of 1921 and 1936

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Molecular Signals of Epigenetic States

(2010) Roberto Bonasio et al.   SCIENCE

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

Dynamic DNA methylation programs persistent adverse effects of early-life stress

(2009) Chris Murgatroyd et al.   NATURE NEUROSCIENCE

Mof (MYST1 or KAT8) Is Essential for Progression of Embryonic Development Past the Blastocyst Stage and Required for Normal Chromatin Architecture

(2008) T. Thomas et al.   MOLECULAR AND CELLULAR BIOLOGY