Understanding the regulation of vertebrate hematopoiesis and blood disorders - big lessons from a small fish

Endothelial-to-hematopoietic transition: Notch-ing vessels into blood

(2016) Dirk Kanz et al.   Annals of the New York Academy of Sciences

Fish to Learn: Insights into Blood Development and Blood Disorders from Zebrafish Hematopoiesis

(2016) Serine Avagyan et al.   HUMAN GENE THERAPY

Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification

(2016) Sven Reischauer et al.   NATURE

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Visualizing Human Hematopoietic Stem Cell Trafficking In Vivo Using a Zebrafish Xenograft Model

(2016) Frank J.T. Staal et al.   STEM CELLS AND DEVELOPMENT

Epigenetic regulation of hematopoiesis by DNA methylation

(2016) Aniket V Gore et al.   eLife

Stable multilineage xenogeneic replacement of definitive hematopoiesis in adult zebrafish

(2016) Isabell Hess et al.   Scientific Reports

Hematopoietic stem cells develop in the absence of endothelialcadherin 5expression

(2015) Heidi Anderson et al.   BLOOD

RAP-011 improves erythropoiesis in zebrafish model of Diamond-Blackfan anemia through antagonizing lefty1

(2015) J. Ear et al.   BLOOD

Elucidation of the EP defect in Diamond-Blackfan anemia by characterization and prospective isolation of human EPs

(2015) D. Iskander et al.   BLOOD

Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium

(2015) I. H. Jang et al.   BLOOD

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

(2015) D. P. Steensma et al.   BLOOD

Hematopoietic Stem Cell Arrival Triggers Dynamic Remodeling of the Perivascular Niche

(2015) Owen J. Tamplin et al.   CELL

Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo

(2015) E. Butko et al.   DEVELOPMENT

Adenosine signaling promotes hematopoietic stem and progenitor cell emergence

(2015) Lili Jing et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish

(2015) Xiaohui Liu et al.   Journal of Hematology & Oncology

A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease

(2015) X Peng et al.   LEUKEMIA

Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment

(2015) Pulin Li et al.   NATURE

Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via Prostaglandin E2 and P-Selectin Activity

(2015) Virginie Esain et al.   STEM CELLS

Primitive macrophages control HSPC mobilization and definitive haematopoiesis

(2015) Jana Travnickova et al.   Nature Communications

Chamber identity programs drive early functional partitioning of the heart

(2015) Christian Mosimann et al.   Nature Communications

Overlapping Requirements for Tet2 and Tet3 in Normal Development and Hematopoietic Stem Cell Emergence

(2015) Cheng Li et al.   Cell Reports

The Ribosome Biogenesis Protein Nol9 Is Essential for Definitive Hematopoiesis and Pancreas Morphogenesis in Zebrafish

(2015) Ewa Bielczyk-Maczyńska et al.   PLoS Genetics

TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis

(2015) Lei Gao et al.   PLoS Genetics

Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling

(2015) Michelle I Lin et al.   eLife

Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia

(2014) B.-L. He et al.   BLOOD

TNF-mediated inflammation represses GATA1 and activates p38 MAP kinase in RPS19-deficient hematopoietic progenitors

(2014) E. Bibikova et al.   BLOOD

CBF  and RUNX1 are required at 2 different steps during the development of hematopoietic stem cells in zebrafish

(2014) E. Bresciani et al.   BLOOD

Clonal analysis identifies hemogenic endothelium as the source of the blood-endothelial common lineage in the mouse embryo

(2014) L. Padron-Barthe et al.   BLOOD

L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way

(2014) Anupama Narla et al.   BRITISH JOURNAL OF HAEMATOLOGY

MDS Is a Stem Cell Disorder After All

(2014) Siddhartha Jaiswal et al.   CANCER CELL

Proinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence

(2014) Raquel Espín-Palazón et al.   CELL

The MHC class I genes of zebrafish

(2014) Hayley Dirscherl et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Ncor1 and Ncor2 play essential but distinct roles in zebrafish primitive myelopoiesis

(2014) Jingyun Li et al.   DEVELOPMENTAL DYNAMICS

The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia

(2014) N. Danilova et al.   Disease Models & Mechanisms

Developmental hematopoiesis: Ontogeny, genetic programming and conservation

(2014) Aldo Ciau-Uitz et al.   EXPERIMENTAL HEMATOLOGY

A Defined Zebrafish Line for High-Throughput Genetics and Genomics: NHGRI-1

(2014) Matthew C. LaFave et al.   GENETICS

A Zebrafish Model of Myelodysplastic Syndrome Produced throughtet2Genomic Editing

(2014) Evisa Gjini et al.   MOLECULAR AND CELLULAR BIOLOGY

Jam1a–Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling

(2014) Isao Kobayashi et al.   NATURE

Optimized cell transplantation using adult rag2 mutant zebrafish

(2014) Qin Tang et al.   NATURE METHODS

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Defects of protein production in erythroid cells revealed in a zebrafish Diamond–Blackfan anemia model for mutation in RPS19

(2014) Y Zhang et al.   Cell Death & Disease

Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation

(2013) C. Cutler et al.   BLOOD

AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/ -catenin signaling pathway

(2013) Y. Zhang et al.   BLOOD

CXCR4 blockade and Sphingosine-1-phosphate activation facilitate engraftment of haematopoietic stem and progenitor cells in a non-myeloablative transplant model

(2013) Nona Shayegi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hemogenic endothelium specification and hematopoietic stem cell maintenance employ distinct Scl isoforms

(2013) Fenghua Zhen et al.   DEVELOPMENT

Multiple divergent haplotypes express completely distinct sets of class I MHC genes in zebrafish

(2013) Sean C. McConnell et al.   IMMUNOGENETICS

Characterization of the Z lineage Major histocompatability complex class I genes in zebrafish

(2013) Hayley Dirscherl et al.   IMMUNOGENETICS

Gata2cis-element is required for hematopoietic stem cell generation in the mammalian embryo

(2013) Xin Gao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gata2is required for HSC generation and survival

(2013) Emma de Pater et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

(2013) T Haferlach et al.   LEUKEMIA

A network of epigenetic regulators guides developmental haematopoiesis in vivo

(2013) Hsuan-Ting Huang et al.   NATURE CELL BIOLOGY

Generating parabiotic zebrafish embryos for cell migration and homing studies

(2013) Doris Lou Demy et al.   NATURE METHODS

Effect of Radiation Dose-Rate on Hematopoietic Cell Engraftment in Adult Zebrafish

(2013) Tiffany J. Glass et al.   PLoS One

Zebrafish model for allogeneic hematopoietic cell transplantation not requiring preconditioning

(2013) Isabell Hess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FLT3-ITDs Instruct a Myeloid Differentiation and Transformation Bias in Lymphomyeloid Multipotent Progenitors

(2013) Adam J. Mead et al.   Cell Reports

Gavaging Adult Zebrafish

(2013) Chereen Collymore et al.   Jove-Journal of Visualized Experiments

L-leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway

(2012) E. M. Payne et al.   BLOOD

SUMO1-activating enzyme subunit 1 is essential for the survival of hematopoietic stem/progenitor cells in zebrafish

(2012) X. Li et al.   DEVELOPMENT

Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning

(2012) Kim-Chew Lim et al.   JOURNAL OF CLINICAL INVESTIGATION

Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition

(2012) P. G. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of immune-matched hematopoietic transplantation in zebrafish

(2011) J. L. O. de Jong et al.   BLOOD

The identification and characterization of zebrafish hematopoietic stem cells

(2011) D. Ma et al.   BLOOD

cpsf1 is required for definitive HSC survival in zebrafish

(2011) N. Bolli et al.   BLOOD

Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish

(2011) C. Zhu et al.   DEVELOPMENT

Rumba and Haus3 are essential factors for the maintenance of hematopoietic stem/progenitor cells during zebrafish hematopoiesis

(2011) L. Du et al.   DEVELOPMENT

Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation

(2011) Alison M. Taylor et al.   EXPERIMENTAL HEMATOLOGY

A somitic Wnt16/Notch pathway specifies haematopoietic stem cells

(2011) Wilson K. Clements et al.   NATURE

Modeling Diamond Blackfan Anemia in the Zebrafish

(2011) Alison M. Taylor et al.   SEMINARS IN HEMATOLOGY

Generation of Highly Homogeneous Strains of Zebrafish Through Full Sib-Pair Mating

(2011) Minori Shinya et al.   G3-Genes Genomes Genetics

Irf8 regulates macrophage versus neutrophil fate during zebrafish primitive myelopoiesis

(2010) L. Li et al.   BLOOD

Notch signaling distinguishes 2 waves of definitive hematopoiesis in the zebrafish embryo

(2010) J. Y. Bertrand et al.   BLOOD

Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells

(2010) E. Y. N. Lam et al.   BLOOD

Ribosomal protein L11 mutation in zebrafish leads to haematopoietic and metabolic defects

(2010) Nadia Danilova et al.   BRITISH JOURNAL OF HAEMATOLOGY

The Hox cofactors Meis1 and Pbx act upstream of gata1 to regulate primitive hematopoiesis

(2010) Laura M. Pillay et al.   DEVELOPMENTAL BIOLOGY

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium

(2010) Jean-Charles Boisset et al.   NATURE

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

(2010) Karima Kissa et al.   NATURE

Haematopoietic stem cells derive directly from aortic endothelium during development

(2010) Julien Y. Bertrand et al.   NATURE

Molecular Signatures of Quiescent, Mobilized and Leukemia-Initiating Hematopoietic Stem Cells

(2010) E. Camilla Forsberg et al.   PLoS One

A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence

(2009) C. E. Burns et al.   BLOOD

Differential requirement for Gata1 DNA binding and transactivation between primitive and definitive stages of hematopoiesis in zebrafish

(2009) C. L. Belele et al.   BLOOD

Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation

(2009) J. Hoggatt et al.   BLOOD

Zebrafish kidney stromal cell lines support multilineage hematopoiesis

(2009) D. L. Stachura et al.   BLOOD

The mouse Runx1 +23 hematopoietic stem cell enhancer confers hematopoietic specificity to both Runx1 promoters

(2009) T. Bee et al.   BLOOD

Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

(2009) Wolfram Goessling et al.   CELL

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

(2009) Michael J. Chen et al.   NATURE

The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage

(2009) Christophe Lancrin et al.   NATURE

Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation

(2009) Jing-Ruey J Yeh et al.   Nature Chemical Biology

Loss of Ribosomal Protein L11 Affects Zebrafish Embryonic Development through a p53-Dependent Apoptotic Response

(2009) Anirban Chakraborty et al.   PLoS One

Both primitive and definitive blood cells are derived from Flk-1+ mesoderm

(2008) J. J. Lugus et al.   BLOOD

ER71 Acts Downstream of BMP, Notch, and Wnt Signaling in Blood and Vessel Progenitor Specification

(2008) Dongjun Lee et al.   Cell Stem Cell

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

(2008) Richard Mark White et al.   Cell Stem Cell

Deficiency of ribosomal protein S19 during early embryogenesis leads to reduction of erythrocytes in a zebrafish model of Diamond-Blackfan anemia

(2008) Tamayo Uechi et al.   HUMAN MOLECULAR GENETICS

Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects

(2008) Kelly A McGowan et al.   NATURE GENETICS