Untangling the complexity of blood coagulation network: use of computational modelling in pharmacology and diagnostics

Next-generation genome-scale models for metabolic engineering

(2015) Zachary A King et al.   CURRENT OPINION IN BIOTECHNOLOGY

Computing the functional proteome: recent progress and future prospects for genome-scale models

(2015) Edward J O’Brien et al.   CURRENT OPINION IN BIOTECHNOLOGY

Compartmentalized calcium signaling triggers subpopulation formation upon platelet activation through PAR1

(2015) Anastasia N. Sveshnikova et al.   Molecular BioSystems

Reconstruction and modeling protein translocation and compartmentalization in Escherichia coli at the genome-scale

(2014) Joanne K Liu et al.   BMC Systems Biology

Predicting dosing advantages of factor VIIa variants with altered tissue factor-dependent and lipid-dependent activities

(2014) A. M. Shibeko et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Thrombosis: Balancing act

(2014) Cassandra Willyard   NATURE

An overview of mathematical modeling of thrombus formation under flow

(2014) Karin Leiderman et al.   THROMBOSIS RESEARCH

Systems Biology and Systems Pharmacology of Thrombosis

(2014) M.A. Panteleev et al.   Mathematical Modelling of Natural Phenomena

Network reconstruction of platelet metabolism identifies metabolic signature for aspirin resistance

(2014) Alex Thomas et al.   Scientific Reports

Computational investigation of potential dosing schedules for a switch of medication from warfarin to rivaroxaban—an oral, direct Factor Xa inhibitor

(2014) Rolf Burghaus et al.   Frontiers in Physiology

Computational Analysis of the Effects of Reduced Temperature on Thrombin Generation

(2013) Alexander Y. Mitrophanov et al.   ANESTHESIA AND ANALGESIA

Modeling thrombin generation: plasma composition based approach

(2013) Kathleen E. Brummel-Ziedins et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

A serendipitously identified novel small molecule procoagulant compound giving rise to a high-throughput screening assay based on human plasma

(2013) David Gustafsson et al.   THROMBOSIS RESEARCH

Drug-drug interaction of the anti-TFPI aptamer BAX499 and factor VIII: Studies of spatial dynamics of fibrin clot formation in hemophilia A

(2013) Leonid A. Parunov et al.   THROMBOSIS RESEARCH

A HYBRID-SYSTEM MODEL OF THE COAGULATION CASCADE: SIMULATION, SENSITIVITY, AND VALIDATION

(2013) JOSEPH G. MAKIN et al.   Journal of Bioinformatics and Computational Biology

Thrombin Activity Propagates in Space During Blood Coagulation as an Excitation Wave

(2012) N.M. Dashkevich et al.   BIOPHYSICAL JOURNAL

Unifying the mechanism of recombinant FVIIa action: dose dependence is regulated differently by tissue factor and phospholipids

(2012) A. M. Shibeko et al.   BLOOD

Multiscale prediction of patient-specific platelet function under flow

(2012) M. H. Flamm et al.   BLOOD

Anticoagulant therapy

(2012) Elena I. Sinauridze et al.   BLOOD COAGULATION & FIBRINOLYSIS

Feasibility of Using Thrombin Generation Assay (TGA) for Monitoring Bypassing Agent Therapy in Patients With Hemophilia Having Inhibitors

(2012) Yilmaz Ay et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Is there value in kinetic modeling of thrombin generation? No (unless…)

(2012) H. C. HEMKER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Defining the Boundaries of Normal Thrombin Generation: Investigations into Hemostasis

(2012) Christopher M. Danforth et al.   PLoS One

Factor Xa Generation by Computational Modeling: An Additional Discriminator to Thrombin Generation Evaluation

(2012) Kathleen E. Brummel-Ziedins et al.   PLoS One

The Prothrombotic Phenotypes in Familial Protein C Deficiency Are Differentiated by Computational Modeling of Thrombin Generation

(2012) Kathleen E. Brummel-Ziedins et al.   PLoS One

Computational analysis of intersubject variability and thrombin generation in dilutional coagulopathy

(2012) Alexander Y. Mitrophanov et al.   TRANSFUSION

Computational Approaches to Studying Thrombus Development

(2011) Zhiliang Xu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Recent advances in the development of coagulation factors and procoagulants for the treatment of hemophilia

(2011) Robert G. Schaub   BIOCHEMICAL PHARMACOLOGY

Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor

(2011) E. K. Waters et al.   BLOOD

Improvement of spatial fibrin formation by the anti-TFPI aptamer BAX499: changing clot size by targeting extrinsic pathway initiation

(2011) L. A. PARUNOV et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Recombinant factor VIIa analog (vatreptacog alfa [activated]) for treatment of joint bleeds in hemophilia patients with inhibitors: a randomized controlled trial

(2011) ERICH V. DE PAULA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Evaluation of the Efficacy and Safety of Rivaroxaban Using a Computer Model for Blood Coagulation

(2011) Rolf Burghaus et al.   PLoS One

Anticoagulants and the Propagation Phase of Thrombin Generation

(2011) Thomas Orfeo et al.   PLoS One

Kinetic modeling sheds light on the mode of action of recombinant factor VIIa on thrombin generation

(2011) Alexander Y. Mitrophanov et al.   THROMBOSIS RESEARCH

Thromboplastin immobilized on polystyrene surface exhibits kinetic characteristics close to those for the native protein and activates in vitro blood coagulation similarly to thromboplastin on fibroblasts

(2010) O. A. Fadeeva et al.   BIOCHEMISTRY-MOSCOW

Task-Oriented Modular Decomposition of Biological Networks: Trigger Mechanism in Blood Coagulation

(2010) Mikhail A. Panteleev et al.   BIOPHYSICAL JOURNAL

Analysis of factor VIIa binding to relipidated tissue factor by surface plasmon resonance

(2010) Prosenjit Sen et al.   BLOOD COAGULATION & FIBRINOLYSIS

Blood flow controls coagulation onset via the positive feedback of factor VII activation by factor Xa

(2010) Alexey M Shibeko et al.   BMC Systems Biology

Coagulation procofactor activation by factor XIa

(2010) M. F. WHELIHAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Anticoagulation by factor Xa inhibitors

(2010) T. ORFEO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Systems Biology of Coagulation Initiation: Kinetics of Thrombin Generation in Resting and Activated Human Blood

(2010) Manash S. Chatterjee et al.   PLoS Computational Biology

A Comprehensive Model for the Humoral Coagulation Network in Humans

(2009) T Wajima et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Empirical and theoretical phenotypic discrimination

(2009) K. E. BRUMMEL-ZIEDINS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The impact of uncertainty in a blood coagulation model

(2009) C. M. Danforth et al.   MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA

Tissue Factor and Factor VIIa as Therapeutic Targets in Disorders of Hemostasis

(2007) Ulla Hedner et al.   Annual Review of Medicine

A multiscale model of thrombus development

(2007) Z. Xu et al.   Journal of the Royal Society Interface