Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism

Discovery and development of small-molecule inhibitors of glycogen synthase

(2020) Buyun Tang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-hypertrophic effect of Na+/H+ exchanger-1 inhibition is mediated by reduced cathepsin B

(2020) Sadaf Riaz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion

(2019) Xiaoyan Zhang et al.   Autophagy

Skeletal Muscle Glycogen Chain Length Correlates with Insolubility in Mouse Models of Polyglucosan-Associated Neurodegenerative Diseases

(2019) Mitchell A. Sullivan et al.   Cell Reports

Antibody-Mediated Enzyme Therapeutics and Applications in Glycogen Storage Diseases

(2019) Zhengqiu Zhou et al.   TRENDS IN MOLECULAR MEDICINE

Lysosomal size matters

(2019) Mariana E. G. Araujo et al.   TRAFFIC

Lessons learned from expanded reproductive carrier screening in self‐reported Ashkenazi, Sephardi, and Mizrahi Jewish patients

(2019) Gidon Akler et al.   Molecular Genetics & Genomic Medicine

Emerging Approaches for the Identification of Protein Targets of Small Molecules - A Practitioners’ Perspective

(2018) Kenneth M. Comess et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux

(2018) Limei Wang et al.   Scientific Reports

KH176 Safeguards Mitochondrial Diseased Cells from Redox Stress-Induced Cell Death by Interacting with the Thioredoxin System/Peroxiredoxin Enzyme Machinery

(2018) Julien Beyrath et al.   Scientific Reports

Program and Abstracts WORLDSymposium 2019* 15th Annual Research Meeting

(2018)   MOLECULAR GENETICS AND METABOLISM

Targeting acute myeloid leukemia by drug-induced c-MYB degradation

(2017) V Walf-Vorderwülbecke et al.   LEUKEMIA

C-X-C Motif Chemokine 10 Impairs Autophagy and Autolysosome Formation in Non-alcoholic Steatohepatitis

(2017) Xiang Zhang et al.   Theranostics

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes

(2016) Kazue Terasawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Starch Binding Domain-containing Protein 1 Plays a Dominant Role in Glycogen Transport to Lysosomes in Liver

(2016) Tao Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader–Willi syndrome

(2016) Ibrahim Knani et al.   Molecular Metabolism

LAMP proteins account for the maturation delay during the establishment of theCoxiella burnetii-containing vacuole

(2015) Jan Schulze-Luehrmann et al.   CELLULAR MICROBIOLOGY

A novel mouse model that recapitulates adult-onset glycogenosis type 4

(2015) H. Orhan Akman et al.   HUMAN MOLECULAR GENETICS

Frequent misdiagnosis of adult polyglucosan body disease

(2015) Mark A. Hellmann et al.   JOURNAL OF NEUROLOGY

The FTMap family of web servers for determining and characterizing ligand-binding hot spots of proteins

(2015) Dima Kozakov et al.   Nature Protocols

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

(2014) V. A. Polito et al.   EMBO Molecular Medicine

The Q Exactive HF, a Benchtop Mass Spectrometer with a Pre-filter, High-performance Quadrupole and an Ultra-high-field Orbitrap Analyzer

(2014) Richard Alexander Scheltema et al.   MOLECULAR & CELLULAR PROTEOMICS

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

The cellular thermal shift assay for evaluating drug target interactions in cells

(2014) Rozbeh Jafari et al.   Nature Protocols

LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity

(2013) K. Krzewski et al.   BLOOD

Adult polyglucosan body disease: Natural History and Key Magnetic Resonance Imaging Findings

(2012) Fanny Mochel et al.   ANNALS OF NEUROLOGY

Lysosomal membrane protein TMEM192 deficiency triggers crosstalk between autophagy and apoptosis in HepG2 hepatoma cells

(2012) ZHEN LIU et al.   ONCOLOGY REPORTS

A guide to analysis of mouse energy metabolism

(2011) Matthias H Tschöp et al.   NATURE METHODS

Fpocket: An open source platform for ligand pocket detection

(2009) Vincent Le Guilloux et al.   BMC BIOINFORMATICS

Clinical outcomes after long-term treatment with alglucosidase alfa in infants and children with advanced Pompe disease

(2009) Marc Nicolino et al.   GENETICS IN MEDICINE

Identifying and Characterizing Binding Sites and Assessing Druggability

(2009) Thomas A. Halgren   Journal of Chemical Information and Modeling

Kirkwood–Buff theory of molecular and protein association, aggregation, and cellular crowding

(2009) Moon Bae Gee et al.   JOURNAL OF CHEMICAL PHYSICS

Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences

(2008) Huan-Xiang Zhou et al.   Annual Review of Biophysics