KH176 Safeguards Mitochondrial Diseased Cells from Redox Stress-Induced Cell Death by Interacting with the Thioredoxin System/Peroxiredoxin Enzyme Machinery

Antioxidants and HNE in redox homeostasis

(2017) Wojciech Łuczaj et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting acute myeloid leukemia by drug-induced c-MYB degradation

(2017) V Walf-Vorderwülbecke et al.   LEUKEMIA

KH176 under development for rare mitochondrial disease: a first in man randomized controlled clinical trial in healthy male volunteers

(2017) Saskia Koene et al.   Orphanet Journal of Rare Diseases

Toward a therapy for mitochondrial disease

(2016) Carlo Viscomi   BIOCHEMICAL SOCIETY TRANSACTIONS

Emerging therapies for mitochondrial disorders

(2016) Helen Nightingale et al.   BRAIN

Idebenone: A Review in Leber’s Hereditary Optic Neuropathy

(2016) Katherine A. Lyseng-Williamson   DRUGS

Mitochondrial disorders in children: toward development of small-molecule treatment strategies

(2016) W. J. Koopman et al.   EMBO Molecular Medicine

The genetics and pathology of mitochondrial disease

(2016) Charlotte L Alston et al.   JOURNAL OF PATHOLOGY

Peroxiredoxins in Regulation of MAPK Signalling Pathways; Sensors and Barriers to Signal Transduction

(2016)   MOLECULES AND CELLS

The Roles of Peroxiredoxin and Thioredoxin in Hydrogen Peroxide Sensing and in Signal Transduction

(2016)   MOLECULES AND CELLS

Oxidative stress in inherited mitochondrial diseases

(2015) Genki Hayashi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Generator-specific targets of mitochondrial reactive oxygen species

(2015) Lea Bleier et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cysteine-mediated redox signalling in the mitochondria

(2015) D. W. Bak et al.   Molecular BioSystems

Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling

(2015) Arden Perkins et al.   TRENDS IN BIOCHEMICAL SCIENCES

Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning

(2015) Lionel Blanchet et al.   Scientific Reports

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

Mitochondrial respiratory chain complexes as sources and targets of thiol-based redox-regulation

(2014) Stefan Dröse et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling

(2014) Mirko C Sobotta et al.   Nature Chemical Biology

Signaling via a peroxiredoxin sensor

(2014) Christine C Winterbourn et al.   Nature Chemical Biology

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Degree of Glutathione Deficiency and Redox Imbalance Depend on Subtype of Mitochondrial Disease and Clinical Status

(2014) Gregory M. Enns et al.   PLoS One

The challenges of using fluorescent probes to detect and quantify specific reactive oxygen species in living cells

(2013) Christine C. Winterbourn   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The thioredoxin antioxidant system

(2013) Jun Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutathione: A redox signature in monitoring EPI-743 therapy in children with mitochondrial encephalomyopathies

(2013) Anna Pastore et al.   MOLECULAR GENETICS AND METABOLISM

Isolated Mitochondrial Complex I Deficiency: Explorative Data Analysis of Patient Cell Parameters

(2012) Lionel Blanchet et al.   CURRENT PHARMACEUTICAL DESIGN

Evaluation of Systemic Redox States in Patients Carrying the MELAS A3243G Mutation in Mitochondrial DNA

(2012) Masamichi Ikawa et al.   EUROPEAN NEUROLOGY

Glutathione/thioredoxin systems modulate mitochondrial H2O2emission: An experimental-computational study

(2012) Miguel Antonio Aon et al.   JOURNAL OF GENERAL PHYSIOLOGY

Mechanisms of mitochondrial diseases

(2011) Emil Ylikallio et al.   ANNALS OF MEDICINE

Peroxiredoxin Functions as a Peroxidase and a Regulator and Sensor of Local Peroxides

(2011) Sue Goo Rhee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NQO1-Dependent Redox Cycling of Idebenone: Effects on Cellular Redox Potential and Energy Levels

(2011) Roman H. Haefeli et al.   PLoS One

Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species

(2010) Andreas Daiber   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease

(2009) F. Distelmaier et al.   BRAIN

Kirkwood–Buff theory of molecular and protein association, aggregation, and cellular crowding

(2009) Moon Bae Gee et al.   JOURNAL OF CHEMICAL PHYSICS

The antioxidant Trolox restores mitochondrial membrane potential and Ca2+-stimulated ATP production in human complex I deficiency

(2009) Felix Distelmaier et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences

(2008) Huan-Xiang Zhou et al.   Annual Review of Biophysics

Mitigation of NADH: Ubiquinone oxidoreductase deficiency by chronic Trolox treatment

(2008) Werner J.H. Koopman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Reconciling the chemistry and biology of reactive oxygen species

(2008) Christine C Winterbourn   Nature Chemical Biology