CRMPs Function in Neurons and Glial Cells: Potential Therapeutic Targets for Neurodegenerative Diseases and CNS Injury

Inhibition of CRMP2 phosphorylation repairs CNS by regulating neurotrophic and inhibitory responses

(2016) Jun Nagai et al.   EXPERIMENTAL NEUROLOGY

Deletion of collapsin response mediator protein 4 results in abnormal layer thickness and elongation of mitral cell apical dendrites in the neonatal olfactory bulb

(2016) Atsuhiro Tsutiya et al.   JOURNAL OF ANATOMY

Loss of collapsin response mediator protein 4 suppresses dopaminergic neuron death in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease

(2016) Aine Tonouchi et al.   JOURNAL OF NEUROCHEMISTRY

Deletion of Crmp4 attenuates CSPG-induced inhibition of axonal growth and induces nociceptive recovery after spinal cord injury

(2016) Jun Nagai et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology

(2016) Aubin Moutal et al.   PAIN

Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus

(2016) Xiaohua Jin et al.   NEURAL PLASTICITY

Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system

(2015) Elly M Hol et al.   CURRENT OPINION IN CELL BIOLOGY

Mouse pups lacking collapsin response mediator protein 4 manifest impaired olfactory function and hyperactivity in the olfactory bulb

(2015) Atsuhiro Tsutiya et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Comprehensive Corticospinal Labeling with mu-crystallin Transgene Reveals Axon Regeneration after Spinal Cord Trauma in ngr1-/- Mice

(2015) K. L. Fink et al.   JOURNAL OF NEUROSCIENCE

(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5

(2015) Aubin Moutal et al.   MOLECULAR NEUROBIOLOGY

CRMPs: critical molecules for neurite morphogenesis and neuropsychiatric diseases

(2015) T T Quach et al.   MOLECULAR PSYCHIATRY

Redox regulation of autophagy in healthy brain and neurodegeneration

(2015) Kenneth Hensley et al.   NEUROBIOLOGY OF DISEASE

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

Systemic administration of epothilone B promotes axon regeneration after spinal cord injury

(2015) J. Ruschel et al.   SCIENCE

Crmp4 deletion promotes recovery from spinal cord injury by neuroprotection and limited scar formation

(2015) Jun Nagai et al.   Scientific Reports

Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons

(2015) Martin Balastik et al.   Cell Reports

CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon Elongation

(2015) Minghui Tan et al.   NEURAL PLASTICITY

Neuronal migration and protein kinases

(2015) Toshio Ohshima   Frontiers in Neuroscience

Neuroprotective Effects of Lithium: Implications for the Treatment of Alzheimer’s Disease and Related Neurodegenerative Disorders

(2014) O. V. Forlenza et al.   ACS Chemical Neuroscience

Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2

(2014) Márcia A Liz et al.   BMC BIOLOGY

Cyclin-Dependent Kinase 5 Regulates Dendritic Spine Formation and Maintenance of Cortical Neuron in the Mouse Brain

(2014) Naoki Mita et al.   CEREBRAL CORTEX

Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones

(2014) Paritosh Prashar et al.   DEVELOPMENTAL BIOLOGY

Collapsin Response Mediator Protein 4 Regulates Growth Cone Dynamics through the Actin and Microtubule Cytoskeleton

(2014) Mohamad R. Khazaei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

CRMP2

(2014) Jacque P.K. Ip et al.   NEUROSCIENTIST

The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth

(2014) Sarah M. Wilson et al.   Frontiers in Cellular Neuroscience

Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review)

(2014) FEI TAN et al.   Oncology Letters

A recoverable state of axon injury persists for hours after spinal cord contusion in vivo

(2014) Philip R. Williams et al.   Nature Communications

Cdk5/p35 functions as a crucial regulator of spatial learning and memory

(2014) Tomohide Mishiba et al.   Molecular Brain

Rewiring of regenerated axons by combining treadmill training with semaphorin3A inhibition

(2014) Liang Zhang et al.   Molecular Brain

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

(2013) S. Lim et al.   DEVELOPMENT

Phosphorylation of Dpsyl2 (CRMP2) and Dpsyl3 (CRMP4) is required for positioning of caudal primary motor neurons in the zebrafish spinal cord

(2013) Rii Morimura et al.   Developmental Neurobiology

Mapping CRMP3 domains involved in dendrite morphogenesis and voltage-gated calcium channel regulation

(2013) T. T. Quach et al.   JOURNAL OF CELL SCIENCE

Dihydropyrimidinase-like 3 regulates the inflammatory response of activated microglia

(2013) J. Manivannan et al.   NEUROSCIENCE

Mice lacking collapsin response mediator protein 1 manifest hyperactivity, impaired learning and memory, and impaired prepulse inhibition

(2013) Naoya Yamashita et al.   Frontiers in Behavioral Neuroscience

Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation

(2012) Steven Petratos et al.   BRAIN

Erratum: Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer

(2012) Atsuko Sakurai et al.   CELL RESEARCH

Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish

(2012) Hideomi Tanaka et al.   DEVELOPMENTAL BIOLOGY

CRMP4 suppresses apical dendrite bifurcation of CA1 pyramidal neurons in the mouse hippocampus

(2012) Emi Niisato et al.   Developmental Neurobiology

Phosphorylation of CRMP2 is involved in proper bifurcation of the apical dendrite of hippocampal CA1 pyramidal neurons

(2012) Emi Niisato et al.   Developmental Neurobiology

Human T Lymphotropic Virus Type 1 Increases T Lymphocyte Migration by Recruiting the Cytoskeleton Organizer CRMP2

(2012) M. Varrin-Doyer et al.   JOURNAL OF IMMUNOLOGY

The Collapsin Response Mediator Protein 5 Onconeural Protein Is Expressed in Schwann Cells Under Axonal Signals and Regulates Axon—Schwann Cell Interactions

(2012) Jean-Philippe Camdessanché et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Loss of Neuron-Astroglial Interaction Rapidly Induces Protective CNTF Expression after Stroke in Mice

(2012) S. S. Kang et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of CRMP2 (Collapsin Response Mediator Protein 2) Is Involved in Proper Dendritic Field Organization

(2012) N. Yamashita et al.   JOURNAL OF NEUROSCIENCE

Collapsin Response Mediator Proteins Regulate Neuronal Development and Plasticity by Switching Their Phosphorylation Status

(2012) Naoya Yamashita et al.   MOLECULAR NEUROBIOLOGY

Prevention of posttraumatic axon sprouting by blocking collapsin response mediator protein 2-mediated neurite outgrowth and tubulin polymerization

(2012) S.M. Wilson et al.   NEUROSCIENCE

CRMP4 mediates MAG-induced inhibition of axonal outgrowth and protection against Vincristine-induced axonal degeneration

(2012) Jun Nagai et al.   NEUROSCIENCE LETTERS

Neuronal Intrinsic Mechanisms of Axon Regeneration

(2011) Kai Liu et al.   Annual Review of Neuroscience

Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase-3 inhibition

(2011) Francois Renault-Mihara et al.   EMBO Molecular Medicine

Identification of a Proline-rich Inositol Polyphosphate 5-Phosphatase (PIPP)·Collapsin Response Mediator Protein 2 (CRMP2) Complex That Regulates Neurite Elongation

(2011) Megan V. Astle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Collapsin Response Mediator Proteins (CRMPs) Are a New Class of Microtubule-associated Protein (MAP) That Selectively Interacts with Assembled Microtubules via a Taxol-sensitive Binding Interaction

(2011) Pao-Chun Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotection against Traumatic Brain Injury by a Peptide Derived from the Collapsin Response Mediator Protein 2 (CRMP2)

(2011) Joel M. Brittain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CRMP5 (Collapsin Response Mediator Protein 5) Regulates Dendritic Development and Synaptic Plasticity in the Cerebellar Purkinje Cells

(2011) N. Yamashita et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation and Cleavage of the Family of Collapsin Response Mediator Proteins May Play a Central Role in Neurodegeneration after CNS Trauma

(2011) Kasra Taghian et al.   JOURNAL OF NEUROTRAUMA

Effect of CRMP3 expression on dystrophic dendrites of hippocampal neurons

(2011) T T Quach et al.   MOLECULAR PSYCHIATRY

ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation

(2011) Shuji Wakatsuki et al.   NATURE CELL BIOLOGY

Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex

(2011) Joel M Brittain et al.   NATURE MEDICINE

Caenorhabditis elegans Hsp70-1 expresses highly in bacteria, is sufficiently soluble, and has a catalytic constant similar to Hsc70 and BiP

(2011) Odutayo O. Odunuga et al.   PROTEIN EXPRESSION AND PURIFICATION

Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury

(2011) F. Hellal et al.   SCIENCE

Reduced expression of plasma membrane calcium ATPase 2 and collapsin response mediator protein 1 promotes death of spinal cord neurons

(2010) M P Kurnellas et al.   CELL DEATH AND DIFFERENTIATION

Post-translational regulation of Crmp in developing and regenerating chick spinal cord

(2010) Stefanie Gögel et al.   Developmental Neurobiology

Neuronal polarization: The cytoskeleton leads the way

(2010) Michael Stiess et al.   Developmental Neurobiology

The Suppression of CRMP2 Expression by Bone Morphogenetic Protein (BMP)-SMAD Gradient Signaling Controls Multiple Stages of Neuronal Development

(2010) Yiming Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CRMP5 Interacts with Tubulin to Inhibit Neurite Outgrowth, Thereby Modulating the Function of CRMP2

(2010) S. Brot et al.   JOURNAL OF NEUROSCIENCE

Proteomic Identification of Binding Partners for the Brain Metabolite Lanthionine Ketimine (LK) and Documentation of LK Effects on Microglia and Motoneuron Cell Cultures

(2010) K. Hensley et al.   JOURNAL OF NEUROSCIENCE

Collapsin Response Mediator Protein 4a (CRMP4a) Is Upregulated in Motoneurons of Mutant SOD1 Mice and Can Trigger Motoneuron Axonal Degeneration and Cell Death

(2010) L. Duplan et al.   JOURNAL OF NEUROSCIENCE

GSK3  Regulates Myelin-Dependent Axon Outgrowth Inhibition through CRMP4

(2010) Y. Z. Alabed et al.   JOURNAL OF NEUROSCIENCE

Protein Phosphatase 2A Facilitates Axonogenesis by Dephosphorylating CRMP2

(2010) L.-Q. Zhu et al.   JOURNAL OF NEUROSCIENCE

Which way to go? Cytoskeletal organization and polarized transport in neurons

(2010) Lukas C. Kapitein et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Emerging Biological Importance of Central Nervous System Lanthionines

(2010) Kenneth Hensley et al.   MOLECULES

Cell mechanics and the cytoskeleton

(2010) Daniel A. Fletcher et al.   NATURE

Injury-induced CRMP4 expression in adult sensory neurons; a possible target gene for ciliary neurotrophic factor

(2010) So Young Jang et al.   NEUROSCIENCE LETTERS

Anterograde Transport of TrkB in Axons Is Mediated by Direct Interaction with Slp1 and Rab27

(2009) Nariko Arimura et al.   DEVELOPMENTAL CELL

Semaphorin3A Signaling Mediated by Fyn-dependent Tyrosine Phosphorylation of Collapsin Response Mediator Protein 2 at Tyrosine 32

(2009) Yutaka Uchida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Collapsin Response Mediator Protein 2 on Tyr-479 Regulates CXCL12-induced T Lymphocyte Migration

(2009) Michel Varrin-Doyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons

(2009) X. X. Chi et al.   JOURNAL OF CELL SCIENCE

Increased proximal bifurcation of CA1 pyramidal apical dendrites insema3Amutant mice

(2009) Fumio Nakamura et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Calpain-truncated CRMP-3 and -4 contribute to potassium deprivation-induced apoptosis of cerebellar granule neurons

(2009) Wei Liu et al.   PROTEOMICS

Relative Resistance of Cdk5-phosphorylated CRMP2 to Dephosphorylation

(2008) Adam R. Cole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule stabilization specifies initial neuronal polarization

(2008) Harald Witte et al.   JOURNAL OF CELL BIOLOGY

Inactivation of Glycogen Synthase Kinase 3 Promotes Axonal Growth and Recovery in the CNS

(2008) J. Dill et al.   JOURNAL OF NEUROSCIENCE

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

(2008) J. E. Herrmann et al.   JOURNAL OF NEUROSCIENCE

Intraspinal MDL28170 Microinjection Improves Functional and Pathological Outcome following Spinal Cord Injury

(2008) Chen-Guang Yu et al.   JOURNAL OF NEUROTRAUMA

CRMP3 is required for hippocampal CA1 dendritic organization and plasticity

(2007) Tam T. Quach et al.   FASEB JOURNAL

High CRMP2 expression in peripheral T lymphocytes is associated with recruitment to the brain during virus-induced neuroinflammation

(2007) C. Vuaillat et al.   JOURNAL OF NEUROIMMUNOLOGY