Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner

Leucine regulates autophagy via acetylation of the mTORC1 component raptor

(2020) Sung Min Son et al.   Nature Communications

Insights into Lysosomal PI(3,5)P2 Homeostasis from a Structural-Biochemical Analysis of the PIKfyve Lipid Kinase Complex

(2020) Joshua A. Lees et al.   MOLECULAR CELL

Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis

(2019) Lorena Fernandez-Mosquera et al.   Autophagy

Transcriptional Regulation of Autophagy: Mechanisms and Diseases

(2019) Chiara Di Malta et al.   Frontiers in Cell and Developmental Biology

The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A

(2018) Claudia Puri et al.   DEVELOPMENTAL CELL

Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells

(2018) Hitoshi Endo et al.   Scientific Reports

An intramolecular interaction within the lipid kinase Fab1 regulates cellular phosphatidylinositol 3,5-bisphosphate lipid levels

(2017) Michael J. Lang et al.   MOLECULAR BIOLOGY OF THE CELL

Polyglutamine tracts regulate beclin 1-dependent autophagy

(2017) Avraham Ashkenazi et al.   NATURE

PIKfyve activity regulates reformation of terminal storage lysosomes from endolysosomes

(2017) Christin Bissig et al.   TRAFFIC

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

(2017) Toby A. Dite et al.   Nature Communications

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2

(2016) S. Fogarty et al.   MOLECULAR CANCER RESEARCH

Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro

(2016) Carolin Walter et al.   NEUROPHARMACOLOGY

PI(5)P Regulates Autophagosome Biogenesis

(2015) Mariella Vicinanza et al.   MOLECULAR CELL

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2

(2013) Fiona McAlpine et al.   Autophagy

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle

(2013) Yang Liu et al.   BIOCHEMICAL JOURNAL

Rhes, a Striatal-selective Protein Implicated in Huntington Disease, Binds Beclin-1 and Activates Autophagy

(2013) Robert G. Mealer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics

(2013) X. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage

(2013) Dennis J. Bua et al.   Scientific Reports

Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636

(2012) Diego Sbrissa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation

(2011) Mario Mauthe et al.   Autophagy

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

(2011) Patrice Codogno et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

(2010) Eisuke Itakura et al.   Autophagy

The Association of AMPK with ULK1 Regulates Autophagy

(2010) Jong Woo Lee et al.   PLoS One

Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway

(2010) X. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Basal autophagy induction without AMP-activated protein kinase under low glucose conditions

(2009) Tyisha Williams et al.   Autophagy

AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity

(2009) C. M. Chresta et al.   CANCER RESEARCH

Morphological and biochemical characterization of basal and starvation-induced autophagy in isolated adult rat cardiomyocytes

(2008) Rumi Maruyama et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells

(2008) F Scarlatti et al.   CELL DEATH AND DIFFERENTIATION

An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE