Immune properties of invertebrate phenoloxidases

A M35 family metalloprotease is required for fungal virulence against insects by inactivating host prophenoloxidases and beyond

(2020) Antian Huang et al.   Virulence

Identification of a Conserved Prophenoloxidase Activation Pathway in Cotton Bollworm Helicoverpa armigera

(2020) Qianran Wang et al.   Frontiers in Immunology

The high-resolution crystal structure of lobster hemocyanin shows its enzymatic capability as a phenoloxidase

(2020) Taro Masuda et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The N-terminal peptide generated after activation of prophenoloxidase affects crayfish hematopoiesis

(2020) Ratchanok Sirikharin et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Venom serine proteinase homolog of the ectoparasitoid Scleroderma guani impairs host phenoloxidase cascade

(2020) Chao-Yan Wu et al.   TOXICON

JNK pathway plays a key role in the immune system of the pea aphid and is regulated by microRNA-184

(2020) Li Ma et al.   PLoS Pathogens

Histological and Comparative Transcriptome Analyses Provide Insights Into the Immune Response in Pearl Sac Formation of Hyriopsis cumingii

(2020) Wenying Shen et al.   Frontiers in Marine Science

Polyphenol oxidases exhibit promiscuous proteolytic activity

(2020) A. Biundo et al.   Communications Chemistry

Laccase and catecholoxidase activities contribute to innate immunity in slipper limpets, Crepidula fornicata

(2020) Emma A. Quinn et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

The CLIP-domain serine protease CLIPC9 regulates melanization downstream of SPCLIP1, CLIPA8, and CLIPA28 in the malaria vector Anopheles gambiae

(2020) Gregory L. Sousa et al.   PLoS Pathogens

The prophenoloxidase system in Drosophila participates in the anti-nematode immune response

(2019) Dustin Cooper et al.   MOLECULAR IMMUNOLOGY

Exaggeration and cooption of innate immunity for social defense

(2019) Mayako Kutsukake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

More Than Black or White: Melanization and Toll Share Regulatory Serine Proteases in Drosophila

(2019) Jan Paul Dudzic et al.   Cell Reports

N-Terminal (1→3)-β-d-Glucan Recognition Proteins from Insects Recognize the Difference in Ultra-Structures of (1→3)-β-d-Glucan

(2019) Adachi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chemical depletion of phagocytic immune cells inAnopheles gambiaereveals dual roles of mosquito hemocytes in anti-Plasmodiumimmunity

(2019) Hyeogsun Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nosema bombycis suppresses host hemolymph melanization through secreted serpin 6 inhibiting the prophenoloxidase activation cascade

(2019) Jialing Bao et al.   JOURNAL OF INVERTEBRATE PATHOLOGY

A fungal pathogen deploys a small silencing RNA that attenuates mosquito immunity and facilitates infection

(2019) Chunlai Cui et al.   Nature Communications

The mosquito melanization response requires hierarchical activation of non-catalytic clip domain serine protease homologs

(2019) Layla El Moussawi et al.   PLoS Pathogens

Bmserpin2 Is Involved in BmNPV Infection by Suppressing Melanization in Bombyx mori

(2019) Shahzad Toufeeq et al.   Insects

Characterization and expression of tyrosinase-like genes in the anemone Exaiptasia pallida as a function of health and symbiotic state

(2019) Grace F. Bailey et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Pattern recognition receptors in annelids

(2019) P. Prochazkova et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Inhibition of immune pathway-initiating hemolymph protease-14 by Manduca sexta serpin-12, a conserved mechanism for the regulation of melanization and Toll activation in insects

(2019) Yang Wang et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes

(2019) Chen Huang et al.   Cell Reports

Effect of the insect phenoloxidase on the metabolism of l -DOPA

(2018) Kai Wu et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

Shrimp humoral responses against pathogens: antimicrobial peptides and melanization

(2018) Anchalee Tassanakajon et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Lipopolysaccharide- and β-1,3-glucan-binding protein from Litopenaeus vannamei : Purification, cloning and contribution in shrimp defense immunity via phenoloxidase activation

(2018) Benjaporn Phupet et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

A novel peptidoglycan recognition protein involved in the prophenoloxidase activation system and antimicrobial peptide production in Antheraea pernyi

(2018) Siqi Zhao et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

A novel white spot syndrome virus protein WSSV164 controls prophenoloxidases, Pm proPOs in shrimp melanization cascade

(2018) Pakkakul Sangsuriya et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Involvement of laccase2 and yellow-e genes in antifungal host defense of the model beetle, Tribolium castaneum

(2018) Yuuki Hayakawa et al.   JOURNAL OF INVERTEBRATE PATHOLOGY

The Circulating Protease Persephone Is an Immune Sensor for Microbial Proteolytic Activities Upstream of the Drosophila Toll Pathway

(2018) Najwa Issa et al.   MOLECULAR CELL

Identification of a phenoloxidase- and melanin-dependent defence mechanism in Achatina fulica infected with Angiostrongylus vasorum

(2018) Aytube Lucas Coaglio et al.   Parasites & Vectors

Strain-specific pathogenicity and subversion of phenoloxidase activity in the mosquito Aedes aegypti by members of the fungal entomopathogenic genus Isaria

(2018) José L. Ramirez et al.   Scientific Reports

Superoxide dismutase from venom of the ectoparasitoid Scleroderma guani inhibits melanization of hemolymph

(2018) Nai-Yong Liu et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

Unbiased classification of mosquito blood cells by single-cell genomics and high-content imaging

(2018) Maiara S. Severo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

White Spot Syndrome Virus-Induced Shrimp miR-315 Attenuates Prophenoloxidase Activation via PPAE3 Gene Suppression

(2018) Phattarunda Jaree et al.   Frontiers in Immunology

Functional amyloidogenesis in immunocytes from the colonial ascidian Botryllus schlosseri: Evolutionary perspective

(2018) Nicola Franchi et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Manipulation of the silkworm immune system by a metalloprotease from the pathogenic bacterium Pseudomonas aeruginosa

(2018) Li Ma et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Transcriptional regulation of Rab32/38, a specific marker of pigment cell formation in Ciona robusta

(2018) Claudia Racioppi et al.   DEVELOPMENTAL BIOLOGY

Melanosomes: Biogenesis, Properties, and Evolution of an Ancient Organelle

(2018) Liliana D’Alba et al.   PHYSIOLOGICAL REVIEWS

A Pacifastacus leniusculus serine protease interacts with WSSV

(2017) Enen Guo et al.   FISH & SHELLFISH IMMUNOLOGY

Identification and characterization of a laccase from Litopenaeus vannamei involved in anti-bacterial host defense

(2017) Lili Shi et al.   FISH & SHELLFISH IMMUNOLOGY

Activation of Aedes aegypti prophenoloxidase-3 and its role in the immune response against entomopathogenic fungi

(2017) Y. Wang et al.   INSECT MOLECULAR BIOLOGY

Anti-melanization mechanism of the white spot syndrome viral protein, WSSV453, via interaction with shrimp proPO-activating enzyme, PmproPPAE2

(2017) Jantiwan Sutthangkul et al.   JOURNAL OF GENERAL VIROLOGY

Recent findings on phenoloxidases in bivalves

(2017) A. Luna-Acosta et al.   MARINE POLLUTION BULLETIN

Dynamics of the Interaction between Cotton BollwormHelicoverpa armigeraand Nucleopolyhedrovirus as Revealed by Integrated Transcriptomic and Proteomic Analyses

(2017) Longsheng Xing et al.   MOLECULAR & CELLULAR PROTEOMICS

Toll ligand Spätzle3 controls melanization in the stripe pattern formation in caterpillars

(2017) Yûsuke KonDo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serpins in arthropod biology

(2017) David A. Meekins et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Identification of a small pacifastin protease inhibitor from Nasonia vitripennis venom that inhibits humoral immunity of host ( Musca domestica )

(2017) Cen Qian et al.   TOXICON

Inhibition of melanization by serpin-5 and serpin-9 promotes baculovirus infection in cotton bollworm Helicoverpa armigera

(2017) Chuanfei Yuan et al.   PLoS Pathogens

Transgenic Expression of the Anti-parasitic Factor TEP1 in the Malaria Mosquito Anopheles gambiae

(2017) Gloria Volohonsky et al.   PLoS Pathogens

Symbiont-induced odorant binding proteins mediate insect host hematopoiesis

(2017) Joshua B Benoit et al.   eLife

Prophenoloxidase-Mediated Ex Vivo Immunity to Delay Fungal Infection after Insect Ecdysis

(2017) Jie Zhang et al.   Frontiers in Immunology

Evolution and Function of Thioester-Containing Proteins and the Complement System in the Innate Immune Response

(2017) Upasana Shokal et al.   Frontiers in Immunology

The structure of a prophenoloxidase (PPO) from Anopheles gambiae provides new insights into the mechanism of PPO activation

(2016) Yingxia Hu et al.   BMC BIOLOGY

Reactive Oxygen Species Affect Transglutaminase Activity and Regulate Hematopoiesis in a Crustacean

(2016) Kingkamon Junkunlo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of hemolymph phenoloxidase activity in two Biomphalaria snail species and impact of Schistosoma mansoni infection

(2016) Winka Le Clec’h et al.   Parasites & Vectors

A mutualistic symbiosis between a parasitic mite and a pathogenic virus undermines honey bee immunity and health

(2016) Gennaro Di Prisco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila innate immunity: regional and functional specialization of prophenoloxidases

(2015) Jan P. Dudzic et al.   BMC BIOLOGY

Suppression of Shrimp Melanization during White Spot Syndrome Virus Infection

(2015) Jantiwan Sutthangkul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional characterization of hesp018, a baculovirus-encoded serpin gene

(2015) Daniel M. P. Ardisson-Araujo et al.   JOURNAL OF GENERAL VIROLOGY

Molecular characterization of a peptidoglycan recognition protein from the cotton bollworm, Helicoverpa armigera and its role in the prophenoloxidase activation pathway

(2015) Yu-Ping Li et al.   MOLECULAR IMMUNOLOGY

Fungal biosynthesis of the bibenzoquinone oosporein to evade insect immunity

(2015) Peng Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plant phenolics are detoxified by prophenoloxidase in the insect gut

(2015) Kai Wu et al.   Scientific Reports

A Critical Role for CLSP2 in the Modulation of Antifungal Immune Response in Mosquitoes

(2015) Yan-Hong Wang et al.   PLoS Pathogens

Molecular Cloning and Functional Studies of Two Kazal-Type Serine Protease Inhibitors Specifically Expressed by Nasonia vitripennis Venom Apparatus

(2015) Cen Qian et al.   Toxins

Clip-domain serine proteases as immune factors in insect hemolymph

(2015) Michael R Kanost et al.   Current Opinion in Insect Science

Evolution of the tyrosinase gene family in bivalve molluscs: Independent expansion of the mantle gene repertoire

(2014) Felipe Aguilera et al.   Acta Biomaterialia

Diverse immune functions of hemocyanins

(2014) Christopher J. Coates et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Characterization of a novel Manduca sexta beta-1, 3-glucan recognition protein (βGRP3) with multiple functions

(2014) Xiang-Jun Rao et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Functional Analysis of Insect Molting Fluid Proteins on the Protection and Regulation of Ecdysis

(2014) Jie Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Self-association of an Insect β-1,3-Glucan Recognition Protein Upon Binding Laminarin Stimulates Prophenoloxidase Activation as an Innate Immune Response

(2014) Daisuke Takahashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional analysis of an immune gene of Spodoptera littoralis by RNAi

(2014) Ilaria Di Lelio et al.   JOURNAL OF INSECT PHYSIOLOGY

An Insecticidal Compound Produced by an Insect-Pathogenic Bacterium Suppresses Host Defenses through Phenoloxidase Inhibition

(2014) Ihsan Ullah et al.   MOLECULES

Prophenoloxidase Activation Is Required for Survival to Microbial Infections in Drosophila

(2014) Olivier Binggeli et al.   PLoS Pathogens

Caspase-1-Like Regulation of the proPO-System and Role of ppA and Caspase-1-Like Cleaved Peptides from proPO in Innate Immunity

(2014) Miti Jearaphunt et al.   PLoS Pathogens

Insect prophenoloxidase: the view beyond immunity

(2014) Anrui Lu et al.   Frontiers in Physiology

Origin, evolution and classification of type-3 copper proteins: lineage-specific gene expansions and losses across the Metazoa

(2013) Felipe Aguilera et al.   BMC EVOLUTIONARY BIOLOGY

Manduca sexta serpin-7, a putative regulator of hemolymph prophenoloxidase activation

(2013) Chansak Suwanchaichinda et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Serine Protease MP2 Activates Prophenoloxidase in the Melanization Immune Response of Drosophila melanogaster

(2013) Chunju An et al.   PLoS One

Molecular characterization of a short peptidoglycan recognition protein (PGRP-S) from Asian corn borer (Ostrinia furnacalis) and its role in triggering proPO activity

(2013) Qiang Sun et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Genetic evidence of a redox-dependent systemic wound response via Hayan Protease-Phenoloxidase system inDrosophila

(2012) Hyuck-Jin Nam et al.   EMBO JOURNAL

An MBL-like protein may interfere with the activation of the proPO-system, an important innate immune reaction in invertebrates

(2012) Chenglin Wu et al.   IMMUNOBIOLOGY

Hindgut Innate Immunity and Regulation of Fecal Microbiota through Melanization in Insects

(2012) Qimiao Shao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for a novel biological role for the multifunctional β-1,3-glucan binding protein in shrimp

(2012) Priscila Goncalves et al.   MOLECULAR IMMUNOLOGY

Small molecule perimeter defense in entomopathogenic bacteria

(2012) J. M. Crawford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unveiling the biosynthetic puzzle of destruxins in Metarhizium species

(2012) B. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Invertebrate Hematopoiesis: An Anterior Proliferation Center As a Link Between the Hematopoietic Tissue and the Brain

(2012) Chadanat Noonin et al.   STEM CELLS AND DEVELOPMENT

Phenoloxidase Activity Acts as a Mosquito Innate Immune Response against Infection with Semliki Forest Virus

(2012) Julio Rodriguez-Andres et al.   PLoS Pathogens

The Mosquito Melanization Response Is Implicated in Defense against the Entomopathogenic Fungus Beauveria bassiana

(2012) Hassan Yassine et al.   PLoS Pathogens

A comparative study of phenoloxidase activity in diseased and bleached colonies of the coral Acropora millepora

(2011) C.V. Palmer et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Phenoloxidase: a key component of the insect immune system

(2011) Isaac González-Santoyo et al.   ENTOMOLOGIA EXPERIMENTALIS ET APPLICATA

First evidence of a potential antibacterial activity involving a laccase-type enzyme of the phenoloxidase system in Pacific oyster Crassostrea gigas haemocytes

(2011) Andrea Luna-Acosta et al.   FISH & SHELLFISH IMMUNOLOGY

Antiviral, anti-parasitic, and cytotoxic effects of 5,6-dihydroxyindole (DHI), a reactive compound generated by phenoloxidase during insect immune response

(2011) Picheng Zhao et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

An insect TEP in a crustacean is specific for cuticular tissues and involved in intestinal defense

(2011) Chenglin Wu et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Functional amyloids in insect immune response

(2011) Patrizia Falabella et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Peptidoglycan activation of the proPO-system without a peptidoglycan receptor protein (PGRP)?

(2010) Haipeng Liu et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

The Drosophila PRR GNBP3 assembles effector complexes involved in antifungal defenses independently of its Toll-pathway activation function

(2010) Alexey A. Matskevich et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Egf1.5 is a second phenoloxidase cascade inhibitor encoded by Microplitis demolitor bracovirus

(2010) Zhiqiang Lu et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Inhibition of melanization by a Nasonia defensin-like peptide: Implications for host immune suppression

(2010) Caihuan Tian et al.   JOURNAL OF INSECT PHYSIOLOGY

Three Pairs of Protease-Serpin Complexes Cooperatively Regulate the Insect Innate Immune Responses

(2009) Rui Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Protein Acts as a Negative Regulator of Prophenoloxidase Activation and Melanization in the Freshwater CrayfishPacifastacus leniusculus

(2009) Irene Söderhäll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic Cascade for the Activation of the Insect Toll Pathway Induced by the Fungal Cell Wall Component

(2009) Kyung-Baeg Roh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

(2009) Edward Owusu-Ansah et al.   NATURE

Solution structure of the silkworm βGRP/GNBP3 N-terminal domain reveals the mechanism for β-1,3-glucan-specific recognition

(2009) Kiyohiro Takahasi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of Manduca sexta prophenoloxidase provides insights into the mechanism of type 3 copper enzymes

(2009) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway

(2009) N. Buchon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissecting the Genetic Basis of Resistance to Malaria Parasites in Anopheles gambiae

(2009) S. A. Blandin et al.   SCIENCE

Leucine-Rich Repeat Protein Complex Activates Mosquito Complement in Defense Against Plasmodium Parasites

(2009) M. Povelones et al.   SCIENCE

Two prophenoloxidases are important for the survival of Vibrio harveyi challenged shrimp Penaeus monodon

(2008) Piti Amparyup et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

A serpin from the parasitoid wasp Leptopilina boulardi targets the Drosophila phenoloxidase cascade

(2008) Dominique Colinet et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation

(2008) Christoph Scherfer et al.   DEVELOPMENTAL BIOLOGY

Molecular Control of Phenoloxidase-induced Melanin Synthesis in an Insect

(2008) Hongnan Kan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Three-step Proteolytic Cascade Mediates the Activation of the Peptidoglycan-induced Toll Pathway in an Insect

(2008) Chan-Hee Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Viral Protein Egf1.0 Is a Dual Activity Inhibitor of Prophenoloxidase-activating Proteinases 1 and 3 fromManduca sexta

(2008) Zhiqiang Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pacifastin-related peptides: Structural and functional characteristics of a family of serine peptidase inhibitors

(2008) Bert Breugelmans et al.   PEPTIDES

The proPO-system: pros and cons for its role in invertebrate immunity

(2008) Lage Cerenius et al.   TRENDS IN IMMUNOLOGY

Fondue and transglutaminase in the Drosophila larval clot

(2007) Malin Lindgren et al.   JOURNAL OF INSECT PHYSIOLOGY