Serine Protease MP2 Activates Prophenoloxidase in the Melanization Immune Response of Drosophila melanogaster

Hemolymph Melanization in the SilkmothBombyx moriInvolves Formation of a High Molecular Mass Complex That Metabolizes Tyrosine

(2013) Kevin D. Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic evidence of a redox-dependent systemic wound response via Hayan Protease-Phenoloxidase system inDrosophila

(2012) Hyuck-Jin Nam et al.   EMBO JOURNAL

Hindgut Innate Immunity and Regulation of Fecal Microbiota through Melanization in Insects

(2012) Qimiao Shao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Properties of Drosophila melanogaster prophenoloxidases expressed in Escherichia coli

(2011) Xuquan Li et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Characterization of a regulatory unit that controls melanization and affects longevity of mosquitoes

(2010) Chunju An et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Serpin-1 splicing isoform J inhibits the proSpätzle-activating proteinase HP8 to regulate expression of antimicrobial hemolymph proteins in Manduca sexta

(2010) Chunju An et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Distinct Melanization Pathways in the Mosquito Aedes aegypti

(2010) Zhen Zou et al.   IMMUNITY

Manduca sexta serpin-5 regulates prophenoloxidase activation and the Toll signaling pathway by inhibiting hemolymph proteinase HP6

(2010) Chunju An et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Serpins Flex Their Muscle

(2010) Gary A. Silverman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic activation and function of the cytokine Spätzle in the innate immune response of a lepidopteran insect, Manduca sexta

(2009) Chunju An et al.   FEBS Journal

Three Pairs of Protease-Serpin Complexes Cooperatively Regulate the Insect Innate Immune Responses

(2009) Rui Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functions ofManduca sextaHemolymph Proteinases HP6 and HP8 in Two Innate Immune Pathways

(2009) Chunju An et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementia

(2009) S. T. Ahmad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation

(2008) Christoph Scherfer et al.   DEVELOPMENTAL BIOLOGY

A Serpin that Regulates Immune Melanization in the Respiratory System of Drosophila

(2008) Huaping Tang et al.   DEVELOPMENTAL CELL

Molecular Control of Phenoloxidase-induced Melanin Synthesis in an Insect

(2008) Hongnan Kan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Three-step Proteolytic Cascade Mediates the Activation of the Peptidoglycan-induced Toll Pathway in an Insect

(2008) Chan-Hee Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The proPO-system: pros and cons for its role in invertebrate immunity

(2008) Lage Cerenius et al.   TRENDS IN IMMUNOLOGY