Repeat proteins: designing new shapes and functions for solenoid folds

Structure-Guided Design of a Peptide Lock for Modular Peptide Binders

(2020) Patrick Ernst et al.   ACS Chemical Biology

A general-purpose protein design framework based on mining sequence–structure relationships in known protein structures

(2020) Jianfu Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

White-emitting Protein-Metal Nanocluster Phosphors for Highly Performing Biohybrid Light-Emitting Diodes

(2020) Antonio Aires et al.   NANO LETTERS

Macromolecular modeling and design in Rosetta: recent methods and frameworks

(2020) Julia Koehler Leman et al.   NATURE METHODS

Engineering and functionalization of large circular tandem repeat protein nanoparticles

(2020) Colin E. Correnti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Modular repeat protein sculpting using rigid helical junctions

(2020) TJ Brunette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo protein design enables the precise induction of RSV-neutralizing antibodies

(2020) Fabian Sesterhenn et al.   SCIENCE

A New Census of Protein Tandem Repeats and Their Relationship with Intrinsic Disorder

(2020) Matteo Delucchi et al.   Genes

Protein Design for the Synthesis and Stabilization of Highly Fluorescent Quantum Dots

(2020) Antonio Aires et al.   CHEMISTRY OF MATERIALS

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

(2020) Aleksandar Antanasijevic et al.   PLoS Pathogens

Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens

(2020) George Ueda et al.   eLife

Expanding the space of protein geometries by computational design of de novo fold families

(2020) Xingjie Pan et al.   SCIENCE

Elfin UI: A Graphical Interface for Protein Design With Modular Building Blocks

(2020) Chun-Ting Yeh et al.   Frontiers in Bioengineering and Biotechnology

RepeatsDB in 2021: improved data and extended classification for protein tandem repeat structures

(2020) Lisanna Paladin et al.   NUCLEIC ACIDS RESEARCH

Scalable Geometrically Designed Protein Cages Assembled via Genetically Encoded Split Inteins

(2019) James N. Wright et al.   STRUCTURE

A simple approach to design proteins for the sustainable synthesis of metal nanoclusters

(2019) Antonio Aires et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Topological control of cytokine receptor signaling induces differential effects in hematopoiesis

(2019) Kritika Mohan et al.   SCIENCE

Controlling protein assembly on inorganic crystals through designed protein interfaces

(2019) Harley Pyles et al.   NATURE

Multi-Scale Structural Analysis of Proteins by Deep Semantic Segmentation

(2019) Raphael R Eguchi et al.   BIOINFORMATICS

Multi-input chemical control of protein dimerization for programming graded cellular responses

(2019) Glenna Wink Foight et al.   NATURE BIOTECHNOLOGY

Unified rational protein engineering with sequence-based deep representation learning

(2019) Ethan C. Alley et al.   NATURE METHODS

Structural analysis of biological targets by host:guest crystal lattice engineering

(2019) Patrick Ernst et al.   Scientific Reports

Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts

(2019) Patrick Ernst et al.   Scientific Reports

Discovering Biomolecules with Huisgenase Activity: Designed Repeat Proteins as Biocatalysts for (3 + 2) Cycloadditions

(2019) Iván Rivilla et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Repeat module-based rational design of a photo-switchable protein for light-driven control of biological processes

(2018) Woosung Heu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Peptide-Guided Assembly of Repeat Protein Fragments

(2018) Erich Michel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Basis for the Selective Inhibition of c-Jun N-Terminal Kinase 1 Determined by Rigid DARPin–DARPin Fusions

(2018) Yufan Wu et al.   JOURNAL OF MOLECULAR BIOLOGY

Curvature of designed armadillo repeat proteins allows modular peptide binding

(2018) Simon Hansen et al.   JOURNAL OF STRUCTURAL BIOLOGY

Elfin: An algorithm for the computational design of custom three-dimensional structures from modular repeat protein building blocks

(2018) Chun-Ting Yeh et al.   JOURNAL OF STRUCTURAL BIOLOGY

Extreme stability in de novo-designed repeat arrays is determined by unusually stable short-range interactions

(2018) Kathryn Geiger-Schuller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Programmed Protein Self-Assembly Driven by Genetically Encoded Intein-Mediated Native Chemical Ligation

(2018) Joseph A. Harvey et al.   ACS Synthetic Biology

An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture

(2018) Mohammad ElGamacy et al.   ACS Synthetic Biology

Peptide binding affinity redistributes preassembled repeat protein fragments

(2018) Erich Michel et al.   BIOLOGICAL CHEMISTRY

De novo design of self-assembling helical protein filaments

(2018) Hao Shen et al.   SCIENCE

Rigidity of the extracellular part of HER2: Evidence from engineering subdomain interfaces and shared-helix DARPin-DARPin fusions

(2017) Christian Jost et al.   PROTEIN SCIENCE

Construction of novel repeat proteins with rigid and predictable structures using a shared helix method

(2017) Suk-Jun Youn et al.   Scientific Reports

A General Computational Approach for Repeat Protein Design

(2015) Fabio Parmeggiani et al.   JOURNAL OF MOLECULAR BIOLOGY

Rational design of α-helical tandem repeat proteins with closed architectures

(2015) Lindsey Doyle et al.   NATURE

Exploring the repeat protein universe through computational protein design

(2015) TJ Brunette et al.   NATURE

Control of repeat-protein curvature by computational protein design

(2015) Keunwan Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Control of repeat-protein curvature by computational protein design

(2015) Keunwan Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tandem-repeat proteins: regularity plus modularity equals design-ability

(2013) Yalda Javadi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Tandem repeats in proteins: From sequence to structure

(2011) Andrey V. Kajava   JOURNAL OF STRUCTURAL BIOLOGY