Mechanism of synaptic protein turnover and its regulation by neuronal activity

Large-scale cell-type-specific imaging of protein synthesis in a vertebrate brain

(2020) Or David Shahar et al.   eLife

Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission

(2020) Matthew P McCabe et al.   eLife

Presynaptic Active Zone Plasticity Encodes Sleep Need in Drosophila

(2020) Sheng Huang et al.   CURRENT BIOLOGY

The Journey of the Synaptic Autophagosome: A Cell Biological Perspective

(2020) Sarah E. Hill et al.   NEURON

Effects of sleep and waking on the synaptic ultrastructure

(2020) Chiara Cirelli et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Proteome dynamics during homeostatic scaling in cultured neurons

(2020) Aline Ricarda Dörrbaum et al.   eLife

Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice

(2020) Sheila Hoffmann-Conaway et al.   eLife

Autophagy in Neuronal Development and Plasticity

(2020) Angeleen Fleming et al.   TRENDS IN NEUROSCIENCES

Autophagy controls the induction and developmental decline of NMDAR-LTD through endocytic recycling

(2020) Hongmei Shen et al.   Nature Communications

Role of mTOR‐regulated autophagy in spine pruning defects and memory impairments induced by binge‐like ethanol treatment in adolescent mice

(2020) María Pascual et al.   BRAIN PATHOLOGY

Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum

(2020) Marijn Kuijpers et al.   NEURON

An activity-dependent local transport regulation via degradation and synthesis of KIF17 underlying cognitive flexibility

(2020) Suguru Iwata et al.   Science Advances

Presynaptic and postsynaptic long-term plasticity in sleep homeostasis

(2020) Sheng Huang et al.   CURRENT OPINION IN NEUROBIOLOGY

Sorting nexin 27 rescues neuroligin 2 from lysosomal degradation to control inhibitory synapse number

(2019) Caroline Binda et al.   BIOCHEMICAL JOURNAL

Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab

(2019) Dawei Wang et al.   ONCOGENE

Bassoon proteinopathy drives neurodegeneration in multiple sclerosis

(2019) Benjamin Schattling et al.   NATURE NEUROSCIENCE

Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial

(2019) Miranka Wirth et al.   Alzheimers Research & Therapy

Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity

(2019) Tamar Farfel-Becker et al.   Cell Reports

Vesicular degradation pathways in neurons: at the crossroads of autophagy and endo-lysosomal degradation

(2019) C Alexander Boecker et al.   CURRENT OPINION IN NEUROBIOLOGY

Neuronal and synaptic protein lifetimes

(2019) Laurie D Cohen et al.   CURRENT OPINION IN NEUROBIOLOGY

Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor

(2019) Sanghyeon Lee et al.   eLife

The many functions of ESCRTs

(2019) Marina Vietri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cellular quality control by the ubiquitin-proteasome system and autophagy

(2019) Christian Pohl et al.   SCIENCE

Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior

(2019) Benjamin H.M. Hunn et al.   Cell Reports

The Synaptic Autophagy Cycle

(2019) Ori J. Lieberman et al.   JOURNAL OF MOLECULAR BIOLOGY

Towards an understanding of Angelman syndrome in mice studies

(2019) Xin Yang   JOURNAL OF NEUROSCIENCE RESEARCH

Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses

(2019) Marta Maglione et al.   Scientific Reports

Live Observation of Two Parallel Membrane Degradation Pathways at Axon Terminals

(2018) Eugene Jennifer Jin et al.   CURRENT BIOLOGY

Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission

(2018) Sven Truckenbrodt et al.   EMBO JOURNAL

Characterization of LAMP1-labeled nondegradative lysosomal and endocytic compartments in neurons

(2018) Xiu-Tang Cheng et al.   JOURNAL OF CELL BIOLOGY

The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility

(2018) Mark J. Wall et al.   NEURON

Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover

(2018) Seok Heo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic analysis of protein turnover in primary cells

(2018) Toby Mathieson et al.   Nature Communications

Local and global influences on protein turnover in neurons and glia

(2018) Aline R Dörrbaum et al.   eLife

Chronic over‐expression of ubiquitin impairs learning, reduces synaptic plasticity, and enhances GRIA receptor turnover in mice

(2018) Jada H. Vaden et al.   JOURNAL OF NEUROCHEMISTRY

Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions

(2018) Eugenio F. Fornasiero et al.   Nature Communications

Mechanisms of AMPA Receptor Endosomal Sorting

(2018) Gabrielle T. Parkinson et al.   Frontiers in Molecular Neuroscience

The effects of proteasomal inhibition on synaptic proteostasis

(2016) Vicky Hakim et al.   EMBO JOURNAL

Activity-Dependent Degradation of Synaptic Vesicle Proteins Requires Rab35 and the ESCRT Pathway

(2016) Patricia Sheehan et al.   JOURNAL OF NEUROSCIENCE

A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals

(2016) Sandra-Fausia Soukup et al.   NEURON

Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy

(2015) Valerie Uytterhoeven et al.   NEURON

Coordinated regulation of protein synthesis and degradation by mTORC1

(2014) Yinan Zhang et al.   NATURE

Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation

(2013) Clarissa L Waites et al.   EMBO JOURNAL

Ubiquitination of Neurotransmitter Receptors and Postsynaptic Scaffolding Proteins

(2013) Amy W. Lin et al.   NEURAL PLASTICITY

Neuronal Stimulation Induces Autophagy in Hippocampal Neurons That Is Involved in AMPA Receptor Degradation after Chemical Long-Term Depression

(2012) M. Shehata et al.   JOURNAL OF NEUROSCIENCE

Loss of Skywalker Reveals Synaptic Endosomes as Sorting Stations for Synaptic Vesicle Proteins

(2011) Valerie Uytterhoeven et al.   CELL

Extensive Remodeling of the Presynaptic Cytomatrix upon Homeostatic Adaptation to Network Activity Silencing

(2011) V. Lazarevic et al.   JOURNAL OF NEUROSCIENCE

Dynein- and activity-dependent retrograde transport of autophagosomes in neuronal axons

(2010) Kiyoshi Katsumata et al.   Autophagy

Autophagy promotes synapse development inDrosophila

(2009) Wei Shen et al.   JOURNAL OF CELL BIOLOGY

Monomeric fluorescent timers that change color from blue to red report on cellular trafficking

(2009) Fedor V Subach et al.   Nature Chemical Biology

A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals

(2008) M. Z. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA