Indole derivatives, microbiome and graft versus host disease

Gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice

(2020) Kunpeng Wu et al.   BLOOD

Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

(2020) Clarissa Campbell et al.   NATURE

Local and Universal Action: The Paradoxes of Indole Signalling in Bacteria

(2020) Ashraf Zarkan et al.   TRENDS IN MICROBIOLOGY

Glucagon like peptide-2 for Intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans

(2020) Johana Norona et al.   BLOOD

Microbiome-intestine cross talk during acute graft-versus-host disease

(2020) Hind Rafei et al.   BLOOD

Association of Short-Chain Fatty Acids in the Gut Microbiome With Clinical Response to Treatment With Nivolumab or Pembrolizumab in Patients With Solid Cancer Tumors

(2020) Motoo Nomura et al.   JAMA Network Open

Functional and phylogenetic alterations in gut microbiome are linked to graft-versus-host disease severity

(2020) Mathilde Payen et al.   Blood Advances

Indoles from the commensal microbiota act via the AHR and IL-10 to tune the cellular composition of the colonic epithelium during aging

(2020) Domonica N. Powell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Harnessing the Chemistry of the Indole Heterocycle to Drive Discoveries in Biology and Medicine

(2019) Verrill M. Norwood IV et al.   CHEMBIOCHEM

Lactose drives Enterococcus expansion to promote graft-versus-host disease

(2019) C. K. Stein-Thoeringer et al.   SCIENCE

Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites

(2019) David Michonneau et al.   Nature Communications

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

Regulation of the Immune Response by the Aryl Hydrocarbon Receptor

(2018) Cristina Gutiérrez-Vázquez et al.   IMMUNITY

Indoles derived from intestinal microbiota act via type I interferon signaling to limit Graft-versus-Host-Disease

(2018) Alyson Swimm et al.   BLOOD

Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease

(2018) Dongchang Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Microbial metabolite sensor GPR43 controls severity of experimental GVHD

(2018) Hideaki Fujiwara et al.   Nature Communications

Altered homeostatic regulation of innate and adaptive immunity in lower gastrointestinal tract GVHD pathogenesis

(2017) James L.M. Ferrara et al.   JOURNAL OF CLINICAL INVESTIGATION

Intestinal Microbiota and Relapse After Hematopoietic-Cell Transplantation

(2017) Jonathan U. Peled et al.   JOURNAL OF CLINICAL ONCOLOGY

Layered defense: how mucus and tight junctions seal the intestinal barrier

(2017) Christopher T. Capaldo et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Feedback control of AHR signalling regulates intestinal immunity

(2017) Chris Schiering et al.   NATURE

Acute Graft-versus-Host Disease — Biologic Process, Prevention, and Therapy

(2017) Robert Zeiser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner

(2017) Troy D. Hubbard et al.   Journal of Functional Foods

The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease

(2016) Anna Staffas et al.   BLOOD

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

(2016) Nathan D Mathewson et al.   NATURE IMMUNOLOGY

Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine

(2016) K. S. Kim et al.   SCIENCE

AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice

(2016) Jeremy A. Goettel et al.   Cell Reports

Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease

(2015) Robert R. Jenq et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

How's your microbiota? Let's check your urine.

(2015) R. R. Jenq   BLOOD

Low urinary indoxyl sulfate levels early after transplantation reflect a disrupted microbiome and are associated with poor outcome

(2015) D. Weber et al.   BLOOD

Innate lymphoid cells in intestinal immunity and inflammation

(2015) John W. Bostick et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Intestinal Microbiota-Derived Metabolomic Blood Plasma Markers for Prior Radiation Injury

(2015) Pilib Ó Broin et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

(2015) Troy D. Hubbard et al.   Scientific Reports

The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation

(2014) Y. Taur et al.   BLOOD

Acute graft-versus-host disease: a bench-to-bedside update

(2014) S. G. Holtan et al.   BLOOD

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

Low Paneth cell numbers at onset of gastrointestinal graft-versus-host disease identify patients at high risk for nonrelapse mortality

(2013) J. E. Levine et al.   BLOOD

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

The Nlrp3 inflammasome regulates acute graft-versus-host disease

(2013) Dragana Jankovic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Family of Indoles Regulate Virulence and Shiga Toxin Production in Pathogenic E. coli

(2013) Bettina Bommarius et al.   PLoS One

Commensal Bacteria-Dependent Indole Production Enhances Epithelial Barrier Function in the Colon

(2013) Yosuke Shimada et al.   PLoS One

Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of  -defensins

(2012) Y. Eriguchi et al.   BLOOD

Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease

(2012) Alan M. Hanash et al.   IMMUNITY

Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation

(2012) Robert R. Jenq et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intestinal Microbiota as Novel Biomarkers of Prior Radiation Exposure

(2012) Vy Lam et al.   RADIATION RESEARCH

IFN-  and indoleamine 2,3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus leukemia activity

(2011) Y. Lu et al.   BLOOD

Tryptophan catabolism is associated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2,3-dioxygenase

(2011) K. Landfried et al.   BLOOD

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Activation of Aryl Hydrocarbon Receptor (AhR) Leads to Reciprocal Epigenetic Regulation of FoxP3 and IL-17 Expression and Amelioration of Experimental Colitis

(2011) Narendra P. Singh et al.   PLoS One

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

(2010) N. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality

(2009) L. K. Jasperson et al.   BLOOD

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation

(2009) T. Bansal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase

(2008) Christoph F.A. Vogel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality

(2007) L. K. Jasperson et al.   BLOOD