Indoles from the commensal microbiota act via the AHR and IL-10 to tune the cellular composition of the colonic epithelium during aging

Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells

(2020) Nick Powell et al.   GUT

Age-associated Impairment of the Mucus Barrier Function is Associated with Profound Changes in Microbiota and Immunity

(2019) Bruno Sovran et al.   Scientific Reports

Human Inflammaging

(2019) Tamàs Fülöp et al.   GERONTOLOGY

Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor

(2018) Erica E. Alexeev et al.   AMERICAN JOURNAL OF PATHOLOGY

The Gut Microbiota and Healthy Aging: A Mini-Review

(2018) Sangkyu Kim et al.   GERONTOLOGY

Gut dysbiosis: a potential link between increased cancer risk in ageing and inflammaging

(2018) Arya Biragyn et al.   LANCET ONCOLOGY

Indoles derived from intestinal microbiota act via type I interferon signaling to limit Graft-versus-Host-Disease

(2018) Alyson Swimm et al.   BLOOD

Age-dependent changes in GI physiology and microbiota: time to reconsider?

(2018) Ran An et al.   GUT

Clinical importance of IL-22 cascade in IBD

(2017) Atsushi Mizoguchi et al.   JOURNAL OF GASTROENTEROLOGY

Layered defense: how mucus and tight junctions seal the intestinal barrier

(2017) Christopher T. Capaldo et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Indoles from commensal bacteria extend healthspan

(2017) Robert Sonowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Aging Analysis in Human Cerebral Cortex Identifies Variants in TMEM106B and GRN that Regulate Aging Phenotypes

(2017) Herve Rhinn et al.   Cell Systems

The ageing gastrointestinal tract

(2016) Stijn Soenen et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration

(2016) Joep Beumer et al.   DEVELOPMENT

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

(2016) François Gerbe et al.   NATURE

Low urinary indoxyl sulfate levels early after transplantation reflect a disrupted microbiome and are associated with poor outcome

(2015) D. Weber et al.   BLOOD

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

(2015) Caroline A. Lindemans et al.   NATURE

Roles of Indole as an Interspecies and Interkingdom Signaling Molecule

(2015) Jin-Hyung Lee et al.   TRENDS IN MICROBIOLOGY

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

(2014) Thaher Pelaseyed et al.   IMMUNOLOGICAL REVIEWS

Attenuation of Intestinal Inflammation in Interleukin-10-Deficient Mice Infected with Citrobacter rodentium

(2014) Sara M. Dann et al.   INFECTION AND IMMUNITY

Circulating Muramyl Dipeptide Is Negatively Associated with Interleukin-10 in the Frail Elderly

(2014) Chris P. Verschoor et al.   INFLAMMATION

Citrobacter rodentium: infection, inflammation and the microbiota

(2014) James W. Collins et al.   NATURE REVIEWS MICROBIOLOGY

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Group 3 Innate Lymphoid Cells Inhibit T-Cell-Mediated Intestinal Inflammation through Aryl Hydrocarbon Receptor Signaling and Regulation of Microflora

(2013) Ju Qiu et al.   IMMUNITY

The Mucin Muc2 Limits Pathogen Burdens and Epithelial Barrier Dysfunction during Salmonella enterica Serovar Typhimurium Colitis

(2013) Maryam Zarepour et al.   INFECTION AND IMMUNITY

A Family of Indoles Regulate Virulence and Shiga Toxin Production in Pathogenic E. coli

(2013) Bettina Bommarius et al.   PLoS One

The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection

(2012) David B. Bartlett et al.   AGING CELL

Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age

(2012) Gautam Sikka et al.   EXPERIMENTAL GERONTOLOGY

Fast Renewal of the Distal Colonic Mucus Layers by the Surface Goblet Cells as Measured by In Vivo Labeling of Mucin Glycoproteins

(2012) Malin E. V. Johansson   PLoS One

Inflammation and mortality in a frail mouse model

(2011) Fred Ko et al.   AGE

The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells

(2011) Ju Qiu et al.   IMMUNITY

Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa

(2010) Kirk S. B. Bergstrom et al.   PLoS Pathogens

Thickness and continuity of the adherent colonic mucus barrier in active and quiescent ulcerative colitis and Crohn’s disease

(2008) V. Strugala et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA