Recent progress and advanced technology in carbohydrate-based drug development

Prophylactic antiviral activity of sulfated glycomimetic oligomers and polymers

(2020) Laura Soria-Martinez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The effects of carbohydrate structure on the composition and functionality of the human gut microbiota

(2020) L. Payling et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Immunology of carbohydrate-based vaccines

(2020) Farjana Khatun et al.   ADVANCED DRUG DELIVERY REVIEWS

Oseltamivir analogs with potent anti-influenza virus activity

(2020) Sumit Kumar et al.   DRUG DISCOVERY TODAY

Receptor-Specific Delivery of Peptide Nucleic Acids Conjugated to Three Sequentially Linked N-Acetyl Galactosamine Moieties into Hepatocytes

(2020) Pramod Bhingardeve et al.   JOURNAL OF ORGANIC CHEMISTRY

Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions

(2020) So Young Kim et al.   ANTIVIRAL RESEARCH

Exploring and applying the substrate promiscuity of a C-glycosyltransferase in the chemo-enzymatic synthesis of bioactive C-glycosides

(2020) Kebo Xie et al.   Nature Communications

Metabolic engineering for production of functional polysaccharides

(2020) Christoph Schilling et al.   CURRENT OPINION IN BIOTECHNOLOGY

Microbe-focused glycan array screening platform

(2019) Andreas Geissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An automated platform for the enzyme-mediated assembly of complex oligosaccharides

(2019) Tiehai Li et al.   Nature Chemistry

Oligosaccharide Synthesis and Translational Innovation

(2019) Larissa Krasnova et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sotagliflozin, the first dual SGLT inhibitor: current outlook and perspectives

(2019) Chiara Maria Assunta Cefalo et al.   Cardiovascular Diabetology

Marine glycan–based antiviral agents in clinical or preclinical trials

(2019) Cui Hao et al.   REVIEWS IN MEDICAL VIROLOGY

Design and synthesis of glycomimetics: Recent advances

(2019) Alice Tamburrini et al.   MEDICINAL RESEARCH REVIEWS

Reprogramming the enzymatic assembly line for site-specific fucosylation

(2019) Jinfeng Ye et al.   Nature Catalysis

Carbohydrate-based nanocarriers and their application to target macrophages and deliver antimicrobial agents

(2019) Tamim Mosaiab et al.   ADVANCED DRUG DELIVERY REVIEWS

Big Data and Artificial Intelligence Modeling for Drug Discovery

(2019) Hao Zhu   Annual Review of Pharmacology and Toxicology

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

(2019) Xinyi Wang et al.   CELL RESEARCH

Glycoconjugate vaccines: current approaches towards faster vaccine design

(2019) Francesca Micoli et al.   Expert Review of Vaccines

Chemoenzymatic Synthesis of Glycosaminoglycans

(2019) Xing Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthetic strategy and SAR studies of C-glucoside heteroaryls as SGLT2 inhibitor: A review

(2019) Kashif Haider et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A β-glucan from Durvillaea Antarctica has immunomodulatory effects on RAW264.7 macrophages via toll-like receptor 4

(2018) Yi Yang et al.   CARBOHYDRATE POLYMERS

Gut commensalParabacteroides goldsteiniiplays a predominant role in the anti-obesity effects of polysaccharides isolated fromHirsutella sinensis

(2018) Tsung-Ru Wu et al.   GUT

Cell-based glycan arrays for probing glycan–glycan binding protein interactions

(2018) Jennie Grace Briard et al.   Nature Communications

Synthesis of Fucoidan-Mimetic Glycopolymers with Well-Defined Sulfation Patterns via Emulsion Ring-Opening Metathesis Polymerization

(2018) Fei Fan et al.   ACS Macro Letters

The Complexity of Fungal β-Glucan in Health and Disease: Effects on the Mononuclear Phagocyte System

(2018) Giorgio Camilli et al.   Frontiers in Immunology

Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1

(2018) Benjamin Schumann et al.   ACS Central Science

Chemoenzymatic Methods for the Synthesis of Glycoproteins

(2018) Chao Li et al.   CHEMICAL REVIEWS

UniLectin3D, a database of carbohydrate binding proteins with curated information on 3D structures and interacting ligands

(2018) François Bonnardel et al.   NUCLEIC ACIDS RESEARCH

Chitosan-Based Nanomaterials for Drug Delivery

(2018) Jianghua Li et al.   MOLECULES

Metabolic engineering of cyanobacteria for photoautotrophic production of heparosan, a pharmaceutical precursor of heparin

(2018) Aditya Sarnaik et al.   Algal Research-Biomass Biofuels and Bioproducts

Heparan Sulfate Proteoglycan Is an Important Attachment Factor for Cell Entry of Akabane and Schmallenberg Viruses

(2017) Shin Murakami et al.   JOURNAL OF VIROLOGY

Chemoenzymatic synthesis of glycoengineered IgG antibodies and glycosite-specific antibody–drug conjugates

(2017) Feng Tang et al.   Nature Protocols

The gut microbiota: A treasure for human health

(2016) Daotong Li et al.   BIOTECHNOLOGY ADVANCES

Cancer control potential of marine natural product scaffolds through inhibition of tumor cell migration and invasion

(2016) Mudit Mudit et al.   DRUG DISCOVERY TODAY

The US regulatory and pharmacopeia response to the global heparin contamination crisis

(2016) Anita Y Szajek et al.   NATURE BIOTECHNOLOGY

Chemical synthesis of erythropoietin glycoforms for insights into the relationship between glycosylation pattern and bioactivity

(2016) M. Murakami et al.   Science Advances

Development of Globo-H Cancer Vaccine

(2015) Samuel J. Danishefsky et al.   ACCOUNTS OF CHEMICAL RESEARCH

Carbohydrate structure database merged from bacterial, archaeal, plant and fungal parts

(2015) Philip V. Toukach et al.   NUCLEIC ACIDS RESEARCH

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Erythropoietin Derived by Chemical Synthesis

(2013) P. Wang et al.   SCIENCE

Chemoenzymatic Synthesis of Homogeneous Ultralow Molecular Weight Heparins

(2011) Y. Xu et al.   SCIENCE

Carbohydrate Polymers at the Center of Life’s Origins: The Importance of Molecular Processivity

(2008) Robert Stern et al.   CHEMICAL REVIEWS