How insects protect themselves against combined starvation and pathogen challenges, and the implications for reductionism

PANEV: an R package for a pathway-based network visualization

(2020) Valentino Palombo et al.   BMC BIOINFORMATICS

Taking Insect Immunity to the Single-Cell Level

(2020) Sarah Hélène Merkling et al.   TRENDS IN IMMUNOLOGY

Genetic Causation in Complex Regulatory Systems: An Integrative Dynamic Perspective

(2020) James DiFrisco et al.   BIOESSAYS

Integrative Methods and Practical Challenges for Single-Cell Multi-omics

(2020) Anjun Ma et al.   TRENDS IN BIOTECHNOLOGY

Getting the most out of reductionist approaches in comparative biochemistry and physiology

(2020) Jason R. Treberg et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Using a newly introduced framework to measure ecological stressor interactions

(2020) Elif Tekin et al.   ECOLOGY LETTERS

Animals have a Plan B: how insects deal with the dual challenge of predators and pathogens

(2020) Shelley A. Adamo   Journal of Comparative Physiology B-Biochemical Systems and Environmental Physiology

Bioenergetics modelling to analyse and predict the joint effects of multiple stressors: Meta-analysis and model corroboration

(2020) Benoit Goussen et al.   SCIENCE OF THE TOTAL ENVIRONMENT

A conceptual model for simulating responses of freshwater macroinvertebrate assemblages to multiple stressors

(2020) Jip de Vries et al.   ECOLOGICAL INDICATORS

A Review of Integrative Imputation for Multi-Omics Datasets

(2020) Meng Song et al.   Frontiers in Genetics

Integrative single-cell analysis

(2019) Tim Stuart et al.   NATURE REVIEWS GENETICS

The Immune Deficiency Pathway Regulates Metabolic Homeostasis in Drosophila

(2019) Saeideh Davoodi et al.   JOURNAL OF IMMUNOLOGY

Immunometabolism: Insights from the Drosophila model

(2019) Anthony Galenza et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Additive bioenergetic responses to a pesticide and predation risk in an aquatic insect

(2019) Marie Van Dievel et al.   AQUATIC TOXICOLOGY

Dietary restriction and insulin‐like signalling pathways as adaptive plasticity: A synthesis and re‐evaluation

(2019) J.C. Regan et al.   FUNCTIONAL ECOLOGY

Diet modulates the relationship between immune gene expression and functional immune responses

(2019) Sheena C. Cotter et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Molecular regulations of metabolism during immune response in insects

(2019) Tomas Dolezal et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Beyond networks: mechanism and process in evo-devo

(2019) James DiFrisco et al.   BIOLOGY & PHILOSOPHY

Bilinear and trilinear modelling of three-way data obtained in two factor designed metabolomics studies

(2019) Jamile Mohammad Jafari et al.   CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS

New insights on Drosophila antimicrobial peptide function in host defense and beyond

(2019) Mark Austin Hanson et al.   CURRENT OPINION IN IMMUNOLOGY

Stress hypothesis overload: 131 hypotheses exploring the role of stress in tradeoffs, transitions, and health

(2019) Breanna N. Harris   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Macronutrients modulate survival to infection and immunity in Drosophila

(2019) Fleur Ponton et al.   JOURNAL OF ANIMAL ECOLOGY

Dietary restriction alters the fatbody transcriptome during immune responses in Bombyx mori

(2018) Ye Pan et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Endocrine and physiological regulation of neutral fat storage in Drosophila

(2018) Michael Lehmann   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Comparative transcriptomics reveals CrebA as a novel regulator of infection tolerance in D. melanogaster

(2018) Katia Troha et al.   PLoS Pathogens

Immune–metabolic interactions during systemic and enteric infection in Drosophila

(2018) Kyung-Ah Lee et al.   Current Opinion in Insect Science

Regulation of antimicrobial peptide genes via insulin-like signaling pathway in the silkworm Bombyx mori

(2018) Jie Zhang et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

The stress response and immune system share, borrow, and reconfigure their physiological network elements: Evidence from the insects

(2017) Shelley A. Adamo   HORMONES AND BEHAVIOR

Plasticity and cross-tolerance to heterogeneous environments: divergent stress responses co-evolved in an African fruit fly

(2017) N. Gotcha et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Acute Dietary Restriction Acts via TOR, PP2A, and Myc Signaling to Boost Innate Immunity in Drosophila

(2017) Jung-Eun Lee et al.   Cell Reports

Sickness behaviour in the cricket Gryllus texensis : Comparison with animals across phyla

(2016) Ken Sullivan et al.   BEHAVIOURAL PROCESSES

Neuropharmacology beyond reductionism – A likely prospect

(2016) Doru Georg Margineanu   BIOSYSTEMS

The role of the hypothalamus-pituitary-adrenal/interrenal axis in mediating predator-avoidance trade-offs

(2016) Breanna N. Harris et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

MOLNs: A Cloud Platform for Interactive, Reproducible, and Scalable Spatial Stochastic Computational Experiments in Systems Biology Using PyURDME

(2016) Brian Drawert et al.   SIAM JOURNAL ON SCIENTIFIC COMPUTING

An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling

(2016) Arunachalam Vinayagam et al.   Cell Reports

Glucose modulatesDrosophilalongevity and immunity independent of the microbiota

(2016) Anthony Galenza et al.   Biology Open

Can we predict the effects of multiple stressors on insects in a changing climate?

(2016) Sirpa Kaunisto et al.   Current Opinion in Insect Science

Insulin/IGF signaling in Drosophila and other insects: factors that regulate production, release and post-release action of the insulin-like peptides

(2015) Dick R. Nässel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Insulin/IGF signaling and its regulation in Drosophila

(2015) Dick R. Nässel et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Editorial: Would You Like A Hypothesis With Those Data? Omics and the Age of Discovery Science

(2015) W. Lee Kraus   MOLECULAR ENDOCRINOLOGY

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

Extracellular Adenosine Mediates a Systemic Metabolic Switch during Immune Response

(2015) Adam Bajgar et al.   PLOS BIOLOGY

The Complex Contributions of Genetics and Nutrition to Immunity in Drosophila melanogaster

(2015) Robert L. Unckless et al.   PLoS Genetics

Genotype and diet shape resistance and tolerance across distinct phases of bacterial infection

(2014) Virginia M Howick et al.   BMC EVOLUTIONARY BIOLOGY

Forkhead, a new cross regulator of metabolism and innate immunity downstream of TOR in Drosophila

(2014) Disha Varma et al.   JOURNAL OF INSECT PHYSIOLOGY

ComPPI: a cellular compartment-specific database for protein–protein interaction network analysis

(2014) Daniel V. Veres et al.   NUCLEIC ACIDS RESEARCH

MEF2 Is an In Vivo Immune-Metabolic Switch

(2013) Rebecca I. Clark et al.   CELL

Cross-tolerance and Cross-talk in the Cold: Relating Low Temperatures to Desiccation and Immune Stress in Insects

(2013) B. J. Sinclair et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

FOXOs: signalling integrators for homeostasis maintenance

(2013) Astrid Eijkelenboom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The characterization of a concentration-sensitive α-adrenergic-like octopamine receptor found on insect immune cells and its possible role in mediating stress hormone effects on immune function

(2012) Jia Huang et al.   BRAIN BEHAVIOR AND IMMUNITY

Integrating nutrition and immunology: A new frontier

(2012) Fleur Ponton et al.   JOURNAL OF INSECT PHYSIOLOGY

Physiological regulatory networks: ecological roles and evolutionary constraints

(2012) Alan A. Cohen et al.   TRENDS IN ECOLOGY & EVOLUTION

Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo

(2011) Federica Parisi et al.   BMC BIOLOGY

Systems biology of infectious diseases: a focus on fungal infections

(2011) Rodrigo Santamaría et al.   IMMUNOBIOLOGY

Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling

(2011) N. Alic et al.   Molecular Systems Biology

FOXO-dependent regulation of innate immune homeostasis

(2010) Thomas Becker et al.   NATURE

Why should an immune response activate the stress response? Insights from the insects (the cricket Gryllus texensis)

(2009) S.A. Adamo   BRAIN BEHAVIOR AND IMMUNITY

The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling

(2009) J. R. DiAngelo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase I to II cross-induction of xenobiotic metabolizing enzymes: A feedforward control mechanism for potential hormetic responses

(2009) Qiang Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Adipokinetic hormone functions that are not associated with insect flight

(2008) DALIBOR KODRÍK   PHYSIOLOGICAL ENTOMOLOGY