Single-cell proteomics: potential implications for cancer diagnostics

Chemical-Free Lysis and Fractionation of Cells by Use of Surface Acoustic Waves for Sensitive Protein Assays

(2015) Ali Salehi-Reyhani et al.   ANALYTICAL CHEMISTRY

Pronase E-Based Generation of Fluorescent Peptide Fragments: Tracking Intracellular Peptide Fate in Single Cells

(2015) Emilie R. Mainz et al.   ANALYTICAL CHEMISTRY

Patient-specific Immune States before Surgery Are Strong Correlates of Surgical Recovery

(2015) Gabriela K. Fragiadakis et al.   ANESTHESIOLOGY

Designed Ankyrin Repeat Proteins (DARPins): Binding Proteins for Research, Diagnostics, and Therapy

(2015) Andreas Plückthun   Annual Review of Pharmacology and Toxicology

Content of Endothelial Progenitor Cells in Autologous Stem Cell Grafts Predict Survival after Transplantation for Multiple Myeloma

(2015) Egil S. Blix et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis

(2015) Jacob H. Levine et al.   CELL

Unraveling cell populations in tumors by single-cell mass cytometry

(2015) Serena Di Palma et al.   CURRENT OPINION IN BIOTECHNOLOGY

Evaluating the efficiency of isotope transmission for improved panel design and a comparison of the detection sensitivities of mass cytometer instruments

(2015) Sabine Tricot et al.   CYTOMETRY PART A

Automatic single cell segmentation on highly multiplexed tissue images

(2015) Peter J. Schüffler et al.   CYTOMETRY PART A

Single-cell mass cytometry reveals intracellular survival/proliferative signaling in FLT3-ITD-mutated AML stem/progenitor cells

(2015) Lina Han et al.   CYTOMETRY PART A

The potential clinical impact of the tissue-based map of the human proteome

(2015) Cecilia Lindskog   Expert Review of Proteomics

Safety and efficacy of imatinib in CML over a period of 10 years: data from the randomized CML-study IV

(2015) L Kalmanti et al.   LEUKEMIA

Proteomic Identification of Cysteine Cathepsin Substrates Shed from the Surface of Cancer Cells

(2015) Barbara Sobotič et al.   MOLECULAR & CELLULAR PROTEOMICS

An Integrated Platform for Isolation, Processing, and Mass Spectrometry-based Proteomic Profiling of Rare Cells in Whole Blood

(2015) Siyang Li et al.   MOLECULAR & CELLULAR PROTEOMICS

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Mass Cytometric Functional Profiling of Acute Myeloid Leukemia Defines Cell-Cycle and Immunophenotypic Properties That Correlate with Known Responses to Therapy

(2015) G. K. Behbehani et al.   Cancer Discovery

Single-Cell Chemical Proteomics with an Activity-Based Probe: Identification of Low-Copy Membrane Proteins on Primary Neurons

(2014) Fei Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

(2014) Petter S. Woll et al.   CANCER CELL

Recent advances in combination of capillary electrophoresis with mass spectrometry: Methodology and theory

(2014) Karel Klepárník   ELECTROPHORESIS

The relevance and potential roles of microphysiological systems in biology and medicine

(2014) John P Wikswo   EXPERIMENTAL BIOLOGY AND MEDICINE

Early onset hypercholesterolemia induced by the 2nd-generation tyrosine kinase inhibitor nilotinib in patients with chronic phase-chronic myeloid leukemia

(2014) D. Rea et al.   HAEMATOLOGICA

Just the FACS

(2014) Lewis L. Lanier   JOURNAL OF IMMUNOLOGY

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

High-dimensional analysis of the murine myeloid cell system

(2014) Burkhard Becher et al.   NATURE IMMUNOLOGY

Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

(2014) Yu-suke Torisawa et al.   NATURE METHODS

Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry

(2014) Charlotte Giesen et al.   NATURE METHODS

Deficient Phosphorylation of Stat1 in Leukocytes Identifies Neutralizing Antibodies in Multiple Sclerosis Patients Treated with Interferon-Beta

(2014) Sonia Gavasso et al.   PLoS One

Automated identification of stratifying signatures in cellular subpopulations

(2014) Robert V. Bruggner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical recovery from surgery correlates with single-cell immune signatures

(2014) B. Gaudilliere et al.   Science Translational Medicine

The microfluidic multitrap nanophysiometer for hematologic cancer cell characterization reveals temporal sensitivity of the calcein-AM efflux assay

(2014) Thomas F. Byrd IV et al.   Scientific Reports

Capillary zone electrophoresis-multiple reaction monitoring from 100 pg of RAW 264.7 cell lysate digest

(2013) Liangliang Sun et al.   ANALYST

Microfluidic Chemical Cytometry of Peptide Degradation in Single Drug-Treated Acute Myeloid Leukemia Cells

(2013) Michelle L. Kovarik et al.   ANALYTICAL CHEMISTRY

High-Throughput Secretomic Analysis of Single Cells to Assess Functional Cellular Heterogeneity

(2013) Yao Lu et al.   ANALYTICAL CHEMISTRY

Development and validation of a single-cell network profiling assay-based classifier to predict response to induction therapy in paediatric patients withde novoacute myeloid leukaemia: a report from the Children's Oncology Group

(2013) Norman J. Lacayo et al.   BRITISH JOURNAL OF HAEMATOLOGY

An introduction to mass cytometry: fundamentals and applications

(2013) Scott D. Tanner et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Pharmacological Profiles of Acute Myeloid Leukemia Treatments in Patient Samples by Automated Flow Cytometry: A Bridge to Individualized Medicine

(2013) Teresa A. Bennett et al.   Clinical Lymphoma Myeloma & Leukemia

Quantitative single cell and single molecule proteomics for clinical studies

(2013) Keith R Willison et al.   CURRENT OPINION IN BIOTECHNOLOGY

High sensitivity capillary zone electrophoresis-electrospray ionization-tandem mass spectrometry for the rapid analysis of complex proteomes

(2013) Liangliang Sun et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Normalization of mass cytometry data with bead standards

(2013) Rachel Finck et al.   CYTOMETRY PART A

Cells, tissues, and organs on chips: challenges and opportunities for the cancer tumor microenvironment

(2013) Edmond W. K. Young   Integrative Biology

Scaling advantages and constraints in miniaturized capture assays for single cell protein analysis

(2013) Ali Salehi-Reyhani et al.   LAB ON A CHIP

CD4 counting technologies for HIV therapy monitoring in resource-poor settings – state-of-the-art and emerging microtechnologies

(2013) Macdara T. Glynn et al.   LAB ON A CHIP

Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients

(2013) S Mustjoki et al.   LEUKEMIA

viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia

(2013) El-ad David Amir et al.   NATURE BIOTECHNOLOGY

Capillary zone electrophoresis for analysis of complex proteomes using an electrokinetically pumped sheath flow nanospray interface

(2013) Liangliang Sun et al.   PROTEOMICS

Individualized Systems Medicine Strategy to Tailor Treatments for Patients with Chemorefractory Acute Myeloid Leukemia

(2013) T. Pemovska et al.   Cancer Discovery

Alternative non-antibody protein scaffolds for molecular imaging of cancer

(2013) Lawrence A Stern et al.   Current Opinion in Chemical Engineering

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

Targeted Single-Cell Microchemical Analysis: MS-Based Peptidomics of Individual Paraformaldehyde-Fixed and Immunolabeled Neurons

(2012) Susanne Neupert et al.   CHEMISTRY & BIOLOGY

Functional pathway analysis in acute myeloid leukemia using single cell network profiling assay: Effect of specimen source (bone marrow or peripheral blood) on assay readouts

(2012) Alessandra Cesano et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Phosphoprotein profiling predicts response to tyrosine kinase inhibitor therapy in chronic myeloid leukemia patients

(2012) Sari E. Jalkanen et al.   EXPERIMENTAL HEMATOLOGY

Mass spectrometry imaging and profiling of single cells

(2012) Eric J. Lanni et al.   Journal of Proteomics

Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells

(2012) Alexis J. Torres et al.   LAB ON A CHIP

Immunogenic effects of recombinant interferon-beta therapy disrupt the JAK/STAT pathway in primary immune cells from patients with multiple sclerosis

(2012) S Gavasso et al.   Multiple Sclerosis Journal

From single cells to deep phenotypes in cancer

(2012) Sean C Bendall et al.   NATURE BIOTECHNOLOGY

The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach

(2012) Jan J. Cornelissen et al.   Nature Reviews Clinical Oncology

Merging Systems Biology with Pharmacodynamics

(2012) R. Iyengar et al.   Science Translational Medicine

Time-dependent biological differences in molecular markers of high-grade urothelial cancer over 7 decades (ras proteins, pTEN, uPAR, PAI-1 and MMP-9)

(2012) Jorunn Litlekalsoy et al.   VIRCHOWS ARCHIV

Single-Cell Pharmacodynamic Monitoring of S6 Ribosomal Protein Phosphorylation in AML Blasts during a Clinical Trial Combining the mTOR Inhibitor Sirolimus and Intensive Chemotherapy

(2011) A. E. Perl et al.   CLINICAL CANCER RESEARCH

Recent advances in single-cell MALDI mass spectrometry imaging and potential clinical impact

(2011) Kristin J Boggio et al.   Expert Review of Proteomics

A first step towards practical single cell proteomics: a microfluidic antibody capture chip with TIRF detection

(2011) Ali Salehi-Reyhani et al.   LAB ON A CHIP

A phase I/II study of imatinib plus reinduction therapy for c-kit-positive relapsed/refractory acute myeloid leukemia: inhibition of Akt activation correlates with complete response

(2011) J M Brandwein et al.   LEUKEMIA

Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE

(2011) Peng Qiu et al.   NATURE BIOTECHNOLOGY

Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia

(2011) N Ånensen et al.   ONCOGENE

Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells

(2011) Q. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia

(2011) J Skavland et al.   Blood Cancer Journal

Poor cytokine-induced phosphorylation in chronic myeloid leukemia patients at diagnosis is effectively reversed by tyrosine kinase inhibitor therapy

(2010) Sari E. Jalkanen et al.   EXPERIMENTAL HEMATOLOGY

Phase I/II Clinical Study of Tosedostat, an Inhibitor of Aminopeptidases, in Patients With Acute Myeloid Leukemia and Myelodysplasia

(2010) Bob Löwenberg et al.   JOURNAL OF CLINICAL ONCOLOGY

Full Dynamic Range Proteome Analysis of S. cerevisiae by Targeted Proteomics

(2009) Paola Picotti et al.   CELL

Design of high-density antibody microarrays for disease proteomics: Key technological issues

(2009) Carl A.K. Borrebaeck et al.   Journal of Proteomics

Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells

(2009) Shannon L. Faley et al.   LAB ON A CHIP

Rapid detection and profiling of cancer cells in fine-needle aspirates

(2009) H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical Cytometry: Fluorescence-Based Single-Cell Analysis

(2008) Daniella Cohen et al.   Annual Review of Analytical Chemistry

Abolition of stress-induced protein synthesis sensitizes leukemia cells to anthracycline-induced death

(2008) G. Gausdal et al.   BLOOD

Single-Cell Profiling Identifies Aberrant STAT5 Activation in Myeloid Malignancies with Specific Clinical and Biologic Correlates

(2008) Nikesh Kotecha et al.   CANCER CELL

Chemical cytometry on microfluidic chips

(2008) Hui Yan et al.   ELECTROPHORESIS