Distinct Phenotypes of Inflammation Associated Macrophages and Microglia in the Prefrontal Cortex Schizophrenia Compared to Controls

A loss of mature microglial markers without immune activation in schizophrenia

(2021) Gijsje J. L. J. Snijders et al.   GLIA

Impaired regulatory T cell control of astroglial overdrive and microglial pruning in schizophrenia

(2021) Fabiana Corsi-Zuelli et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Microglia activation in postmortem brains with schizophrenia demonstrates distinct morphological changes between brain regions

(2021) Ryan Gober et al.   BRAIN PATHOLOGY

Reduced adult neurogenesis is associated with increased macrophages in the subependymal zone in schizophrenia

(2021) Christin Weissleder et al.   MOLECULAR PSYCHIATRY

Abnormal microglial reactivity in gray matter of the prefrontal cortex in schizophrenia

(2021) N.A. Uranova et al.   Asian Journal of Psychiatry

Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion

(2020) Jason R. Plemel et al.   Science Advances

Regional, cellular and species difference of two key neuroinflammatory genes implicated in schizophrenia

(2020) Caitlin E. Murphy et al.   BRAIN BEHAVIOR AND IMMUNITY

Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease

(2020) Luana da Silva Chagas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuronal activity increases translocator protein (TSPO) levels

(2020) Tina Notter et al.   MOLECULAR PSYCHIATRY

Protective Microglial Subset in Development, Aging, and Disease: Lessons From Transcriptomic Studies

(2020) Anouk Benmamar-Badel et al.   Frontiers in Immunology

Perspective: Solving the Heterogeneity Conundrum of TSPO PET Imaging in Psychosis

(2020) Livia De Picker et al.   Frontiers in Psychiatry

Nuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines

(2020) Caitlin E. Murphy et al.   Journal of Neuroinflammation

Novel Hexb-based tools for studying microglia in the CNS

(2020) Takahiro Masuda et al.   NATURE IMMUNOLOGY

Quantitative immunohistochemical analysis of myeloid cell marker expression in human cortex captures microglia heterogeneity with anatomical context

(2020) Molly E. V. Swanson et al.   Scientific Reports

Astrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer’s Disease

(2020) Benjamin B. Tournier et al.   JOURNAL OF ALZHEIMERS DISEASE

Multivariate relationships between peripheral inflammatory marker subtypes and cognitive and brain structural measures in psychosis

(2020) Paulo Lizano et al.   MOLECULAR PSYCHIATRY

Large-Scale Evidence for an Association Between Peripheral Inflammation and White Matter Free Water in Schizophrenia and Healthy Individuals

(2020) Maria A Di Biase et al.   SCHIZOPHRENIA BULLETIN

Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia

(2020) Tertia D. Purves-Tyson et al.   Frontiers in Immunology

Monocyte Transmodulation: The Next Novel Therapeutic Approach in Overcoming Ischemic Stroke?

(2020) Joohyun Park et al.   Frontiers in Neurology

CSF1R Stimulation Promotes Increased Neuroprotection by CD11c+ Microglia in EAE

(2019) Agnieszka Wlodarczyk et al.   Frontiers in Cellular Neuroscience

Increased levels of midbrain immune-related transcripts in schizophrenia and in murine offspring after maternal immune activation

(2019) Tertia D. Purves-Tyson et al.   MOLECULAR PSYCHIATRY

More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis

(2019) Martha Gschwandtner et al.   Frontiers in Immunology

The Role of the Nuclear Factor-κB Transcriptional Complex in Cortical Immune Activation in Schizophrenia

(2018) David W. Volk et al.   BIOLOGICAL PSYCHIATRY

Transcriptomic evidence for alterations in astrocytes and parvalbumin interneurons in bipolar disorder and schizophrenia subjects

(2018) Lilah Toker et al.   BIOLOGICAL PSYCHIATRY

A Combination of Ontogeny and CNS Environment Establishes Microglial Identity

(2018) F. Chris Bennett et al.   NEURON

Interaction between TSPO—a neuroimmune marker—and redox status in clinical high risk for psychosis: a PET–MRS study

(2018) Sina Hafizi et al.   NEUROPSYCHOPHARMACOLOGY

Microglia-Astrocyte Crosstalk: An Intimate Molecular Conversation

(2018) Mithilesh Kumar Jha et al.   NEUROSCIENTIST

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

(2018) Michael J. Gandal et al.   SCIENCE

Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures

(2018) Carole Sousa et al.   EMBO REPORTS

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice

(2018) M. S. Unger et al.   Journal of Neuroinflammation

Increased macrophages and changed brain endothelial cell gene expression in the frontal cortex of people with schizophrenia displaying inflammation

(2018) Helen Q. Cai et al.   MOLECULAR PSYCHIATRY

CNS-border associated macrophages respond to acute ischemic stroke attracting granulocytes and promoting vascular leakage

(2018) Jordi Pedragosa et al.   Acta Neuropathologica Communications

Unravelling the Interplay between Extracellular Acidosis and Immune Cells

(2018) Fernando Erra Díaz et al.   MEDIATORS OF INFLAMMATION

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

(2018) Michael J. Gandal et al.   SCIENCE

Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

(2018) Sara Bachiller et al.   Frontiers in Cellular Neuroscience

Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury

(2018) Andrew D. Greenhalgh et al.   PLOS BIOLOGY

Spatial Mapping of Myeloid Cells and Macrophages by Multiplexed Tissue Staining

(2018) Joshua Saylor et al.   Frontiers in Immunology

Brain perivascular macrophages: characterization and functional roles in health and disease

(2017) Giuseppe Faraco et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology

(2017) Debbie A.E. Hendrickx et al.   JOURNAL OF NEUROIMMUNOLOGY

Using blood cytokine measures to define high inflammatory biotype of schizophrenia and schizoaffective disorder

(2017) Danny Boerrigter et al.   Journal of Neuroinflammation

Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [11C]PBR28

(2017) K Collste et al.   MOLECULAR PSYCHIATRY

Translational evaluation of translocator protein as a marker of neuroinflammation in schizophrenia

(2017) T Notter et al.   MOLECULAR PSYCHIATRY

Comprehensive transcriptome analysis of neocortical layers in humans, chimpanzees and macaques

(2017) Zhisong He et al.   NATURE NEUROSCIENCE

Role of microglia disturbances and immune-related marker abnormalities in cortical circuitry dysfunction in schizophrenia

(2017) David W. Volk   NEUROBIOLOGY OF DISEASE

Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders

(2017) Hideo Hagihara et al.   NEUROPSYCHOPHARMACOLOGY

Expression of iNOS, CD163 and ARG-1 taken as M1 and M2 markers of microglial polarization in human glioblastoma and the surrounding normal parenchyma

(2017) L. Lisi et al.   NEUROSCIENCE LETTERS

Role of infiltrating monocytes/macrophages in acute and chronic neuroinflammation: Effects on cognition, learning and affective behaviour

(2017) Aedín M. Minogue   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A Study of TNF Pathway Activation in Schizophrenia and Bipolar Disorder in Plasma and Brain Tissue

(2017) Eva Zsuzsanna Hoseth et al.   SCHIZOPHRENIA BULLETIN

Microglia Responses in Acute and Chronic Neurological Diseases: What Microglia-Specific Transcriptomic Studies Taught (and did Not Teach) Us

(2017) Hélène E. Hirbec et al.   Frontiers in Aging Neuroscience

PET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia

(2017) M A Di Biase et al.   Translational Psychiatry

Immune involvement in the pathogenesis of schizophrenia: a meta-analysis on postmortem brain studies

(2017) C F M G van Kesteren et al.   Translational Psychiatry

Abnormal gene and protein expression of inflammatory cytokines in the postmortem brain of schizophrenia patients

(2017) Ghanshyam N. Pandey et al.   SCHIZOPHRENIA RESEARCH

Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [11C]PBR28 PET Brain Imaging Study

(2016) Peter S. Bloomfield et al.   AMERICAN JOURNAL OF PSYCHIATRY

Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease

(2016) Willem Kamphuis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Immunosenescence of microglia and macrophages: impact on the ageing central nervous system

(2016) Khalil S. Rawji et al.   BRAIN

Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review

(2016) M O Trépanier et al.   MOLECULAR PSYCHIATRY

Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus

(2016) Nicholas H. Varvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortical grey matter volume reduction in people with schizophrenia is associated with neuro-inflammation

(2016) Y Zhang et al.   Translational Psychiatry

Molecular Mechanisms and Timing of Cortical Immune Activation in Schizophrenia

(2015) David W. Volk et al.   AMERICAN JOURNAL OF PSYCHIATRY

Tumor-associated macrophages in oral premalignant lesions coexpress CD163 and STAT1 in a Th1-dominated microenvironment

(2015) Kazumasa Mori et al.   BMC CANCER

Age decreases macrophage IL-10 expression: Implications for functional recovery and tissue repair in spinal cord injury

(2015) Bei Zhang et al.   EXPERIMENTAL NEUROLOGY

CX3CR1 is dysregulated in blood and brain from schizophrenia patients

(2015) Aurélie Bergon et al.   SCHIZOPHRENIA RESEARCH

Pathologic and Protective Roles for Microglial Subsets and Bone Marrow- and Blood-Derived Myeloid Cells in Central Nervous System Inflammation

(2015) Agnieszka Wlodarczyk et al.   Frontiers in Immunology

Increased expression of astrocyte markers in schizophrenia: Association with neuroinflammation

(2014) Vibeke Sørensen Catts et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Reduced microglial immunoreactivity for endogenous NMDA receptor agonist quinolinic acid in the hippocampus of schizophrenia patients

(2014) Tomasz Gos et al.   BRAIN BEHAVIOR AND IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Unique Expression of Suppressor of Cytokine Signaling 3 Is Essential for Classical Macrophage Activation in Rodents In Vitro and In Vivo

(2014) Yu Liu et al.   JOURNAL OF IMMUNOLOGY

CCL2 Shapes Macrophage Polarization by GM-CSF and M-CSF: Identification of CCL2/CCR2-Dependent Gene Expression Profile

(2014) E. Sierra-Filardi et al.   JOURNAL OF IMMUNOLOGY

Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study

(2014) Pascal F. Durrenberger et al.   JOURNAL OF NEURAL TRANSMISSION

Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis

(2014) Roy Y. Kim et al.   JOURNAL OF NEUROIMMUNOLOGY

Comparison of microglia and infiltrating CD11c+ cells as antigen presenting cells for T cell proliferation and cytokine response

(2014) Agnieszka Wlodarczyk et al.   Journal of Neuroinflammation

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Conditional Ablation of Astroglial CCL2 Suppresses CNS Accumulation of M1 Macrophages and Preserves Axons in Mice with MOG Peptide EAE

(2014) M. Moreno et al.   JOURNAL OF NEUROSCIENCE

Towards a Psychosis Risk Blood Diagnostic for Persons Experiencing High-Risk Symptoms: Preliminary Results From the NAPLS Project

(2014) Diana O. Perkins et al.   SCHIZOPHRENIA BULLETIN

Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder

(2014) S G Fillman et al.   Translational Psychiatry

Expression of immune genes on chromosome 6p21.3–22.1 in schizophrenia

(2013) Melissa L. Sinkus et al.   BRAIN BEHAVIOR AND IMMUNITY

Macrophage Polarisation: an Immunohistochemical Approach for Identifying M1 and M2 Macrophages

(2013) Mário Henrique M. Barros et al.   PLoS One

Identification of Subgroups of Schizophrenia Patients With Changes in Either Immune or Growth Factor and Hormonal Pathways

(2013) E. Schwarz et al.   SCHIZOPHRENIA BULLETIN

Increased expression of glial fibrillary acidic protein in prefrontal cortex in psychotic illness

(2013) Abigail H. Feresten et al.   SCHIZOPHRENIA RESEARCH

Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: Further evidence for disease course-related immune alterations?

(2012) Stefan Busse et al.   BRAIN BEHAVIOR AND IMMUNITY

Lesional Accumulation of CD163+ Macrophages/microglia in Rat Traumatic Brain Injury

(2012) Zhiren Zhang et al.   BRAIN RESEARCH

Role of interplay between IL-4 and IFN-γ in the in regulating M1 macrophage polarization induced by Nattectin

(2012) Edson Kiyotaka Ishizuka et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Reactive Astrocytes Overexpress TSPO and Are Detected by TSPO Positron Emission Tomography Imaging

(2012) S. Lavisse et al.   JOURNAL OF NEUROSCIENCE

Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia

(2012) S G Fillman et al.   MOLECULAR PSYCHIATRY

Meta-Analysis of Cytokine Alterations in Schizophrenia: Clinical Status and Antipsychotic Effects

(2011) Brian J. Miller et al.   BIOLOGICAL PSYCHIATRY

Risperidone normalizes increased inflammatory parameters and restores anti-inflammatory pathways in a model of neuroinflammation

(2011) Karina S. MacDowell et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Parenchymal accumulation of CD163+ macrophages/microglia in multiple sclerosis brains

(2011) Zhiren Zhang et al.   JOURNAL OF NEUROIMMUNOLOGY

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

Altered MHC class I expression in dorsolateral prefrontal cortex of nonsmoker patients with schizophrenia

(2011) Shin-ichi Kano et al.   NEUROSCIENCE RESEARCH

Neuronal MCP-1 Mediates Microglia Recruitment and Neurodegeneration Induced by the Mild Impairment of Oxidative Metabolism

(2010) Guang Yang et al.   BRAIN PATHOLOGY

Cingulate White Matter Neurons in Schizophrenia and Bipolar Disorder

(2009) Caroline M. Connor et al.   BIOLOGICAL PSYCHIATRY

Role of Chemokines in CNS Health and Pathology: A Focus on the CCL2/CCR2 and CXCL8/CXCR2 Networks

(2009) Bridgette D Semple et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroinflammation in Schizophrenia-Related Psychosis: A PET Study

(2009) J. Doorduin et al.   JOURNAL OF NUCLEAR MEDICINE

The Stanley Neuropathology Consortium Integrative Database: a Novel, Web-Based Tool for Exploring Neuropathological Markers in Psychiatric Disorders and the Biological Processes Associated with Abnormalities of Those Markers

(2009) Sanghyeon Kim et al.   NEUROPSYCHOPHARMACOLOGY

CD163, a Marker of Perivascular Macrophages, Is Up-Regulated by Microglia in Simian Immunodeficiency Virus Encephalitis after Haptoglobin-Hemoglobin Complex Stimulation and Is Suggestive of Breakdown of the Blood-Brain Barrier

(2008) Juan T. Borda et al.   AMERICAN JOURNAL OF PATHOLOGY

Microglia Activation in Recent-Onset Schizophrenia: A Quantitative (R)-[11C]PK11195 Positron Emission Tomography Study

(2008) Bart N. van Berckel et al.   BIOLOGICAL PSYCHIATRY

Atypical antipsychotics suppress production of proinflammatory cytokines and up-regulate interleukin-10 in lipopolysaccharide-treated mice

(2008) Haruhiko Sugino et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Inflammatory Cytokine Alterations in Schizophrenia: A Systematic Quantitative Review

(2007) Stéphane Potvin et al.   BIOLOGICAL PSYCHIATRY

Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide

(2006) Johann Steiner et al.   JOURNAL OF PSYCHIATRIC RESEARCH