Synaptic alterations associated with depression and schizophrenia: potential as a therapeutic target
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Synaptic alterations associated with depression and schizophrenia: potential as a therapeutic target
Authors
Keywords
-
Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 20, Issue 10, Pages 1195-1207
Publisher
Informa UK Limited
Online
2016-05-11
DOI
10.1080/14728222.2016.1188080
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Gene—Environment Interactions in Major Depressive Disorder
- (2017) Torsten Klengel et al. CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
- Neuronal and brain morphological changes in animal models of schizophrenia
- (2016) Gonzalo Flores et al. BEHAVIOURAL BRAIN RESEARCH
- BDNF – a key transducer of antidepressant effects
- (2016) Carl Björkholm et al. NEUROPHARMACOLOGY
- Chronic Mild Stress Modulates Activity-Dependent Transcription of BDNF in Rat Hippocampal Slices
- (2016) Raffaella Molteni et al. NEURAL PLASTICITY
- Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics
- (2015) Chadi G. Abdallah et al. Annual Review of Medicine
- DecreasedBdnfexpression and reduced social behavior in periadolescent rats following prenatal stress
- (2015) Alessandra Berry et al. DEVELOPMENTAL PSYCHOBIOLOGY
- Lurasidone Exerts Antidepressant Properties in the Chronic Mild Stress Model through the Regulation of Synaptic and Neuroplastic Mechanisms in the Rat Prefrontal Cortex
- (2015) Alessia Luoni et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- PI3K/AKT/mTOR Signaling-Mediated Neuropeptide VGF in the Hippocampus of Mice Is Involved in the Rapid Onset Antidepressant-Like Effects of GLYX-13
- (2015) Yang Lu et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Evaluation of TrkB and BDNF transcripts in prefrontal cortex, hippocampus, and striatum from subjects with schizophrenia, bipolar disorder, and major depressive disorder
- (2015) Veronica Reinhart et al. NEUROBIOLOGY OF DISEASE
- Neuroligin-2 Expression in the Prefrontal Cortex is Involved in Attention Deficits Induced by Peripubertal Stress
- (2015) Stamatina Tzanoulinou et al. NEUROPSYCHOPHARMACOLOGY
- Erratum: Ketamine: Promising Path or False Prophecy in the Development of Novel Therapeutics for Mood Disorders?
- (2015) Gerard Sanacora et al. NEUROPSYCHOPHARMACOLOGY
- Serum brain-derived neurotrophic factor and cortical thickness are differently related in patients with schizophrenia and controls
- (2015) Andre Zugman et al. PSYCHIATRY RESEARCH-NEUROIMAGING
- Hippocampal neuroligin-2 links early-life stress with impaired social recognition and increased aggression in adult mice
- (2015) Christine Kohl et al. PSYCHONEUROENDOCRINOLOGY
- Involvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed mice
- (2015) Juanjuan Tang et al. Scientific Reports
- The Global Burden of Mental, Neurological and Substance Use Disorders: An Analysis from the Global Burden of Disease Study 2010
- (2015) Harvey A. Whiteford et al. PLoS One
- Blood BDNF Level Is Gender Specific in Severe Depression
- (2015) Anatoly Kreinin et al. PLoS One
- Effects of mood-stabilizing drugs on dendritic outgrowth and synaptic protein levels in primary hippocampal neurons
- (2014) Sung Woo Park et al. BIPOLAR DISORDERS
- Delayed BDNF alterations in the prefrontal cortex of rats exposed to prenatal stress: Preventive effect of lurasidone treatment during adolescence
- (2014) A. Luoni et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Exposure to early life stress regulates Bdnf expression in SERT mutant rats in an anatomically selective fashion
- (2014) Francesca Calabrese et al. JOURNAL OF NEUROCHEMISTRY
- REDD1 is essential for stress-induced synaptic loss and depressive behavior
- (2014) Kristie T Ota et al. NATURE MEDICINE
- Impact of maternal separation on neural cell adhesion molecules expression in dopaminergic brain regions of juvenile, adolescent and adult rats
- (2014) Agnieszka Chocyk et al. Pharmacological Reports
- Early-life stress affects the structural and functional plasticity of the medial prefrontal cortex in adolescent rats
- (2013) Agnieszka Chocyk et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists
- (2013) Joseph R Moskal et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Regulation of the spatial code for BDNF mRNA isoforms in the rat hippocampus following pilocarpine-treatment: A systematic analysis using laser microdissection and quantitative real-time PCR
- (2013) Gabriele Baj et al. HIPPOCAMPUS
- Lack of Serotonin Transporter Alters BDNF Expression in the Rat Brain During Early Postnatal Development
- (2013) Francesca Calabrese et al. MOLECULAR NEUROBIOLOGY
- Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism differentially predicts hippocampal function in medication-free patients with schizophrenia
- (2013) D P Eisenberg et al. MOLECULAR PSYCHIATRY
- Serotonin 2C receptor antagonists induce fast-onset antidepressant effects
- (2013) M D Opal et al. MOLECULAR PSYCHIATRY
- Reduced neuroplasticity in aged rats: a role for the neurotrophin brain-derived neurotrophic factor
- (2013) Francesca Calabrese et al. NEUROBIOLOGY OF AGING
- BDNF-induced local protein synthesis and synaptic plasticity
- (2013) Graciano Leal et al. NEUROPHARMACOLOGY
- GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects
- (2013) Jeffrey Burgdorf et al. NEUROPSYCHOPHARMACOLOGY
- Impaired Hippocampal Neuroligin-2 Function by Chronic Stress or Synthetic Peptide Treatment is Linked to Social Deficits and Increased Aggression
- (2013) Michael A van der Kooij et al. NEUROPSYCHOPHARMACOLOGY
- Hippocampal Neuroligin-2 Overexpression Leads to Reduced Aggression and Inhibited Novelty Reactivity in Rats
- (2013) Christine Kohl et al. PLoS One
- A positive correlation between serum levels of mature brain-derived neurotrophic factor and negative symptoms in schizophrenia
- (2013) Tomihisa Niitsu et al. PSYCHIATRY RESEARCH
- Transient activation of mTOR following forced treadmill exercise in rats
- (2013) Betina Elfving et al. SYNAPSE
- Developmental delays and reduced pup ultrasonic vocalizations but normal sociability in mice lacking the postsynaptic cell adhesion protein neuroligin2
- (2012) Markus Wöhr et al. BEHAVIOURAL BRAIN RESEARCH
- Acute Increases in Plasma Mammalian Target of Rapamycin, Glycogen Synthase Kinase-3β, and Eukaryotic Elongation Factor 2 Phosphorylation After Ketamine Treatment in Three Depressed Patients
- (2012) Chun Yang et al. BIOLOGICAL PSYCHIATRY
- Rapid and Longer-Term Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression
- (2012) James W. Murrough et al. BIOLOGICAL PSYCHIATRY
- Amygdala activity and prefrontal cortex-amygdala effective connectivity to emerging emotional faces distinguish remitted and depressed mood states in bipolar disorder
- (2012) Susan B Perlman et al. BIPOLAR DISORDERS
- Behavioural and neuroplastic properties of chronic lurasidone treatment in serotonin transporter knockout rats
- (2012) Alessia Luoni et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Amygdala response and functional connectivity during emotion regulation: A study of 14 depressed adolescents
- (2012) Greg Perlman et al. JOURNAL OF AFFECTIVE DISORDERS
- Mammalian Target of Rapamycin Complex 1 (mTORC1) and 2 (mTORC2) Control the Dendritic Arbor Morphology of Hippocampal Neurons
- (2012) Malgorzata Urbanska et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Variant Brain-Derived Neurotrophic Factor Val66Met Polymorphism Alters Vulnerability to Stress and Response to Antidepressants
- (2012) H. Yu et al. JOURNAL OF NEUROSCIENCE
- Decreased expression of synapse-related genes and loss of synapses in major depressive disorder
- (2012) Hyo Jung Kang et al. NATURE MEDICINE
- Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy
- (2012) Mark J. Millan et al. NATURE REVIEWS DRUG DISCOVERY
- Neurotrophin regulation of neural circuit development and function
- (2012) Hyungju Park et al. NATURE REVIEWS NEUROSCIENCE
- Maternal deprivation effects on brain plasticity and recognition memory in adolescent male and female rats
- (2012) Eva M. Marco et al. NEUROPHARMACOLOGY
- Stress during development alters dendritic morphology in the nucleus accumbens and prefrontal cortex
- (2012) A. Muhammad et al. NEUROSCIENCE
- Dendritic spine pathology in schizophrenia
- (2012) J.R. Glausier et al. NEUROSCIENCE
- Neurobiology of chronic mild stress: Parallels to major depression
- (2012) Matthew N. Hill et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Antidepressant Treatment Normalizes White Matter Volume in Patients with Major Depression
- (2012) Ling-Li Zeng et al. PLoS One
- Reduced phosphorylation of the mTOR signaling pathway components in the amygdala of rats exposed to chronic stress
- (2012) Agata Chandran et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Modulation of neuronal plasticity following chronic concomitant administration of the novel antipsychotic lurasidone with the mood stabilizer valproic acid
- (2012) F. Calabrese et al. PSYCHOPHARMACOLOGY
- Synaptic Dysfunction in Depression: Potential Therapeutic Targets
- (2012) R. S. Duman et al. SCIENCE
- Monitoring Ketamine Treatment Response in a Depressed Patient via Peripheral Mammalian Target of Rapamycin Activation
- (2011) Magdalena C. Denk et al. AMERICAN JOURNAL OF PSYCHIATRY
- Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure
- (2011) Nanxin Li et al. BIOLOGICAL PSYCHIATRY
- Chronic stress induces changes in the structure of interneurons and in the expression of molecules related to neuronal structural plasticity and inhibitory neurotransmission in the amygdala of adult mice
- (2011) Javier Gilabert-Juan et al. EXPERIMENTAL NEUROLOGY
- Modulation of BDNF expression by repeated treatment with the novel antipsychotic lurasidone under basal condition and in response to acute stress
- (2011) Fabio Fumagalli et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Prenatal stress alters hippocampal synaptic plasticity in young rat offspring through preventing the proteolytic conversion of pro-brain-derived neurotrophic factor (BDNF) to mature BDNF
- (2011) Che-Ming Yeh et al. JOURNAL OF PHYSIOLOGY-LONDON
- The AMPA receptor potentiator Org 26576 modulates stress-induced transcription of BDNF isoforms in rat hippocampus
- (2011) Fabio Fumagalli et al. PHARMACOLOGICAL RESEARCH
- Antistress properties of antidepressant drugs and their clinical implications
- (2011) Francesca Calabrese et al. PHARMACOLOGY & THERAPEUTICS
- Spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct dendritic compartments
- (2011) G. Baj et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder
- (2011) Courtney S. Jernigan et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Serum BDNF levels before treatment predict SSRI response in depression
- (2011) Owen M. Wolkowitz et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Age of Onset of Schizophrenia: Perspectives From Structural Neuroimaging Studies
- (2011) N. Gogtay et al. SCHIZOPHRENIA BULLETIN
- Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits
- (2010) Avshalom Caspi et al. AMERICAN JOURNAL OF PSYCHIATRY
- Long-Term Duloxetine Treatment Normalizes Altered Brain-Derived Neurotrophic Factor Expression in Serotonin Transporter Knockout Rats through the Modulation of Specific Neurotrophin Isoforms
- (2010) F. Calabrese et al. MOLECULAR PHARMACOLOGY
- Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders
- (2010) S Kim et al. MOLECULAR PSYCHIATRY
- Serum levels of brain-derived neurotrophic factor in major depressive disorder: state–trait issues, clinical features and pharmacological treatment
- (2010) M L Molendijk et al. MOLECULAR PSYCHIATRY
- Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis
- (2010) M J Green et al. MOLECULAR PSYCHIATRY
- The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research?
- (2010) G MacQueen et al. MOLECULAR PSYCHIATRY
- Modulation of neuroplastic molecules in selected brain regions after chronic administration of the novel antidepressant agomelatine
- (2010) Francesca Calabrese et al. PSYCHOPHARMACOLOGY
- mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
- (2010) N. Li et al. SCIENCE
- Synaptic degeneration in Alzheimer’s disease
- (2009) Thomas Arendt ACTA NEUROPATHOLOGICA
- Progressive Gray Matter Reduction of the Superior Temporal Gyrus During Transition to Psychosis
- (2009) Tsutomu Takahashi et al. ARCHIVES OF GENERAL PSYCHIATRY
- Early life stress, the development of aggression and neuroendocrine and neurobiological correlates: What can we learn from animal models?
- (2009) Alexa H. Veenema FRONTIERS IN NEUROENDOCRINOLOGY
- Effects of neonatal stress on markers of synaptic plasticity in the hippocampus: Implications for spatial memory
- (2009) Bárbara Aisa et al. HIPPOCAMPUS
- Causal evidence for the involvement of the neural cell adhesion molecule, NCAM, in chronic stress-induced cognitive impairments
- (2009) Reto Bisaz et al. HIPPOCAMPUS
- Lipid raft-targeted Akt promotes axonal branching and growth cone expansion via mTOR and Rac1, respectively
- (2009) M.H. Grider et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Effects of stress throughout the lifespan on the brain, behaviour and cognition
- (2009) Sonia J. Lupien et al. NATURE REVIEWS NEUROSCIENCE
- Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans
- (2009) Raffaella Molteni et al. NEUROBIOLOGY OF DISEASE
- Neurocircuitry of Mood Disorders
- (2009) Joseph L Price et al. NEUROPSYCHOPHARMACOLOGY
- Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery
- (2009) D.S. Goldwater et al. NEUROSCIENCE
- Antipsychotic drug actions on gene modulation and signaling mechanisms
- (2009) Raffaella Molteni et al. PHARMACOLOGY & THERAPEUTICS
- Analysis of the neuroligin 4Y gene in patients with autism
- (2009) Jin Yan et al. PSYCHIATRIC GENETICS
- Associative learning and the genetics of schizophrenia
- (2009) Jeremy Hall et al. TRENDS IN NEUROSCIENCES
- The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders
- (2009) Catalina Betancur et al. TRENDS IN NEUROSCIENCES
- BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses
- (2009) Kurt Gottmann et al. EXPERIMENTAL BRAIN RESEARCH
- Disruption of Neurexin 1 Associated with Autism Spectrum Disorder
- (2008) Hyung-Goo Kim et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications
- (2008) Srijan Sen et al. BIOLOGICAL PSYCHIATRY
- Distinct Role of Long 3′ UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons
- (2008) Juan Ji An et al. CELL
- Synaptic Imbalance, Stereotypies, and Impaired Social Interactions in Mice with Altered Neuroligin 2 Expression
- (2008) R. M. Hines et al. JOURNAL OF NEUROSCIENCE
- Depression-prone mice with reduced glucocorticoid receptor expression display an altered stress-dependent regulation of brain-derived neurotrophic factor and activity-regulated cytoskeleton-associated protein
- (2008) R. Molteni et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity
- (2008) M Verhagen et al. MOLECULAR PSYCHIATRY
- Correlation analysis between genome-wide expression profiles and cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders
- (2008) S Kim et al. MOLECULAR PSYCHIATRY
- Neuroligins and neurexins link synaptic function to cognitive disease
- (2008) Thomas C. Südhof NATURE
- Acute Stress Responsiveness of the Neurotrophin BDNF in the Rat Hippocampus is Modulated by Chronic Treatment with the Antidepressant Duloxetine
- (2008) Raffaella Molteni et al. NEUROPSYCHOPHARMACOLOGY
- Effects of social isolation rearing on the limbic brain: A combined behavioral and magnetic resonance imaging volumetry study in rats
- (2008) M.I. Schubert et al. NEUROSCIENCE
- Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia
- (2008) T. Walsh et al. SCIENCE
- Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex
- (2007) Jason J. Radley et al. JOURNAL OF COMPARATIVE NEUROLOGY
- BDNF mRNA splice variants display activity-dependent targeting to distinct hippocampal laminae
- (2007) C. Chiaruttini et al. MOLECULAR AND CELLULAR NEUROSCIENCE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now