Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells

A Kinase-Independent Role for EGF Receptor in Autophagy Initiation

(2015) Xiaojun Tan et al.   CELL

LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation

(2015) X. Tan et al.   EMBO JOURNAL

Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo

(2015) Julia Cuende et al.   Science Translational Medicine

Overexpression of LAPTM4B is correlated with tumor angiogenesis and poor prognosis in non-small cell lung cancer

(2014) Han Tang et al.   MEDICAL ONCOLOGY

Overexpression of LAPTM4B-35: A Novel Marker of Poor Prognosis of Prostate Cancer

(2014) Hongtuan Zhang et al.   PLoS One

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Elevated Lysosome-Associated Protein Transmembrane-4β-35 is an Independent Prognostic Marker in Pancreatic Carcinoma

(2013) G Zhang et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Regulatory T cells: recommendations to simplify the nomenclature

(2013) Abul K Abbas et al.   NATURE IMMUNOLOGY

GARP Is Regulated by miRNAs and Controls Latent TGF-β1 Production by Human Regulatory T Cells

(2013) Emilie Gauthy et al.   PLoS One

Overexpression of LAPTM4B-35 is associated with poor prognosis in colorectal carcinoma

(2012) Yue Kang et al.   AMERICAN JOURNAL OF SURGERY

Comparative study of regulatory T cells expanded ex vivo from cord blood and adult peripheral blood

(2012) Huahua Fan et al.   IMMUNOLOGY

GARP regulates the bioavailability and activation of TGFβ

(2012) Rui Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Over-expression of LAPTM4B is associated with poor prognosis and chemotherapy resistance in stages III and IV epithelial ovarian cancer

(2011) Mingzhu Yin et al.   JOURNAL OF SURGICAL ONCOLOGY

A Role for the Ubiquitin Ligase Nedd4 in Membrane Sorting of LAPTM4 Proteins

(2011) Ruth Milkereit et al.   PLoS One

Overexpression of LAPTM4B-35 promotes growth and metastasis of hepatocellular carcinoma in vitro and in vivo

(2010) Hua Yang et al.   CANCER LETTERS

Frequency of Circulating Tregs with Demethylated FOXP3 Intron 1 in Melanoma Patients Receiving Tumor Vaccines and Potentially Treg-Depleting Agents

(2010) I. J. M. de Vries et al.   CLINICAL CANCER RESEARCH

LAPTM4B overexpression is a novel predictor of epithelial ovarian carcinoma metastasis

(2010) Mingzhu Yin et al.   INTERNATIONAL JOURNAL OF CANCER

Development and characterisation of an assay for furin activity

(2010) Gemma L. Bourne et al.   JOURNAL OF IMMUNOLOGICAL METHODS

A Role for Lysosomal-Associated Protein Transmembrane 5 in the Negative Regulation of Surface B Cell Receptor Levels and B Cell Activation

(2010) R. Ouchida et al.   JOURNAL OF IMMUNOLOGY

LAPTM4B-35 is a novel prognostic factor of hepatocellular carcinoma

(2010) Hua Yang et al.   JOURNAL OF SURGICAL ONCOLOGY

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

(2010) Ye Zheng et al.   NATURE

Quantitative DNA Methylation Analysis of FOXP3 as a New Method for Counting Regulatory T Cells in Peripheral Blood and Solid Tissue

(2009) G. Wieczorek et al.   CANCER RESEARCH

LAPTM4B-35, a novel tetratransmembrane protein and its PPRP motif play critical roles in proliferation and metastatic potential of hepatocellular carcinoma cells

(2009) Xinrong Liu et al.   CANCER SCIENCE

Membrane protein GARP is a receptor for latent TGF-β on the surface of activated human Treg

(2009) Julie Stockis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Comparison of stable human Treg and Th clones by transcriptional profiling

(2009) Julie Stockis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

LAPTM4B-35 overexpression is a risk factor for tumor recurrence and poor prognosis in hepatocellular carcinoma

(2009) Hua Yang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

GARP (LRRC32) is essential for the surface expression of latent TGF-  on platelets and activated FOXP3+ regulatory T cells

(2009) D. Q. Tran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of LAPTM4B-35: A novel marker of progression, invasiveness and poor prognosis of extrahepatic cholangiocarcinoma

(2008) Li Zhou et al.   CANCER LETTERS

DNA methylation controls Foxp3 gene expression

(2008) Julia K. Polansky et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Lysosomal Protein Negatively Regulates Surface T Cell Antigen Receptor Expression by Promoting CD3ζ-Chain Degradation

(2008) Rika Ouchida et al.   IMMUNITY

Identification of a Regulatory T Cell Specific Cell Surface Molecule that Mediates Suppressive Signals and Induces Foxp3 Expression

(2008) Rui Wang et al.   PLoS One

Clinical Grade Treg: GMP Isolation, Improvement of Purity by CD127pos Depletion, Treg Expansion, and Treg Cryopreservation

(2008) Jorieke H. Peters et al.   PLoS One

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology