RORγ antagonists and inverse agonists: a patent review

Therapeutic Targeting of IL-17 and IL-23 Cytokines in Immune-Mediated Diseases

(2016) George E. Fragoulis et al.   Annual Review of Medicine

Retinoid-related orphan receptor gamma t (RORγt) inhibitors from Vitae Pharmaceuticals (WO2015116904) and structure proposal for their Phase I candidate VTP-43742

(2016) Christian Gege   EXPERT OPINION ON THERAPEUTIC PATENTS

ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer

(2016) Junjian Wang et al.   NATURE MEDICINE

Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin

(2016) Susan H. Smith et al.   PLoS One

Discovery of N -(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent RORγt inverse agonists

(2015) Yonghui Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

ROR Inverse Agonist Suppresses Insulitis and Prevents Hyperglycemia in a Mouse Model of Type 1 Diabetes

(2015) Laura A. Solt et al.   ENDOCRINOLOGY

The psoriasis drugs market

(2015) Salman Rizvi et al.   NATURE REVIEWS DRUG DISCOVERY

Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

(2015) S. Okada et al.   SCIENCE

Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors

(2015) Yonghui Wang et al.   ACS Medicinal Chemistry Letters

SAR Exploration Guided by LE and Fsp3: Discovery of a Selective and Orally Efficacious RORγ Inhibitor

(2015) Kazuyuki Hirata et al.   ACS Medicinal Chemistry Letters

ROR nuclear receptors: structures, related diseases and drug discovery

(2014) Yan Zhang et al.   ACTA PHARMACOLOGICA SINICA

Inhibiting RORγt/Th17 axis for autoimmune disorders

(2014) Fujio Isono et al.   DRUG DISCOVERY TODAY

Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms

(2014) Sheng Xiao et al.   IMMUNITY

Modulators of the Nuclear Receptor Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ or RORc)

(2014) Benjamin P. Fauber et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Th17 cells in autoimmune diseases

(2014) Jianfei Yang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action

(2014) Olivier René et al.   ACS Medicinal Chemistry Letters

Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent RORγt inhibitors

(2013) Yonghui Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of Tertiary Amine and Indole Derivatives as Potent RORγt Inverse Agonists

(2013) Ting Yang et al.   ACS Medicinal Chemistry Letters