Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 57, Issue 14, Pages 5871-5892Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm401901d
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As the biology surrounding the nuclear receptor retinoic acid receptor-related orphan receptor-gamma (ROR gamma or RORc) continues to evolve, significant effort has been invested in discovering modulators of this potentially important target for the treatment of metabolic and immunological diseases. Several major pharmaceutical and biotechnology companies have disclosed RORc inhibitors or partnered with other players in the field. In this perspective, we discuss both the biology and the underlying structural biology of RORc, and summarize the RORc modulators disclosed in the scientific and patent literature.
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