NAD + Redox Imbalance in the Heart Exacerbates Diabetic Cardiomyopathy

Basic Mechanisms of Diabetic Heart Disease

(2020) Rebecca H. Ritchie et al.   CIRCULATION RESEARCH

Hepatic NADH reductive stress underlies common variation in metabolic traits

(2020) Russell P. Goodman et al.   NATURE

Methylene blue decreases mitochondrial lysine acetylation in the diabetic heart

(2017) Jessica M. Berthiaume et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy

(2017) Nicolas Diguet et al.   CIRCULATION

An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers

(2017) Sophia E. Airhart et al.   PLoS One

Mitochondrial NAD+/NADH Redox State and Diabetic Cardiomyopathy

(2017) Jessica M. Berthiaume et al.   ANTIOXIDANTS & REDOX SIGNALING

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

(2016) Natalie E. de Picciotto et al.   AGING CELL

Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts

(2016) Ying Ann Chiao et al.   Aging-US

Nicotinamide adenine dinucleotide homeostasis and signalling in heart disease: Pathophysiological implications and therapeutic potential

(2016) Mathias Mericskay   Archives of Cardiovascular Diseases

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

(2016) Kathryn F. Mills et al.   Cell Metabolism

Normalization of NAD+Redox Balance as a Therapy for Heart FailureClinical Perspective

(2016) Chi Fung Lee et al.   CIRCULATION

Diabetes-associated cardiac fibrosis: Cellular effectors, molecular mechanisms and therapeutic opportunities

(2016) Ilaria Russo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

(2016) Samuel A. J. Trammell et al.   Nature Communications

Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

(2016) Samuel A.J. Trammell et al.   Scientific Reports

Globally Optimized Targeted Mass Spectrometry: Reliable Metabolomics Analysis with Broad Coverage

(2015) Haiwei Gu et al.   ANALYTICAL CHEMISTRY

Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis

(2015) Patrick A. Carroll et al.   CANCER CELL

Mitochondrial complex I defect and increased fatty acid oxidation enhance protein lysine acetylation in the diabetic heart

(2015) Edwin J. Vazquez et al.   CARDIOVASCULAR RESEARCH

AMPK: a cellular energy sensor primarily regulated by AMP

(2014) Graeme J. Gowans et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1

(2014) Andrew Moore et al.   Cardiovascular Diabetology

Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP

(2014) F. Romana Auciello et al.   FEBS LETTERS

Combined troponin I Ser-150 and Ser-23/24 phosphorylation sustains thin filament Ca2+ sensitivity and accelerates deactivation in an acidic environment

(2014) Benjamin R. Nixon et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic Profiling of Alternative NAD Biosynthetic Routes in Mouse Tissues

(2014) Valerio Mori et al.   PLoS One

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

(2013) Graeme J. Gowans et al.   Cell Metabolism

Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure

(2013) Georgios Karamanlidis et al.   Cell Metabolism

Calorie restriction and sirtuins revisited

(2013) L. Guarente   GENES & DEVELOPMENT

Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling

(2012) Vinodkumar B. Pillai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

AMP-Activated Protein Kinase Phosphorylates Cardiac Troponin I and Alters Contractility of Murine Ventricular Myocytes

(2012) Sandra Marisa Oliveira et al.   CIRCULATION RESEARCH

AMP-activated Protein Kinase Phosphorylates Cardiac Troponin I at Ser-150 to Increase Myofilament Calcium Sensitivity and Blunt PKA-dependent Function

(2012) Benjamin R. Nixon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy

(2011) Dao-Fu Dai et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Analysis of cardiac myosin binding protein-C phosphorylation in human heart muscle

(2010) O'Neal Copeland et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Diabetic cardiomyopathy, causes and effects

(2010) Sihem Boudina et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Nicotinamide Phosphoribosyltransferase Regulates Cell Survival Through NAD + Synthesis in Cardiac Myocytes

(2009) Chiao-Po Hsu et al.   CIRCULATION RESEARCH