Methylene blue decreases mitochondrial lysine acetylation in the diabetic heart

Nutrient sensing and utilization: Getting to the heart of metabolic flexibility

(2016) Timothy M. Griffin et al.   BIOCHIMIE

Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH

(2016) Andreas S. Madsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation of Mitochondrial Trifunctional Protein α-Subunit Enhances Its Stability To Promote Fatty Acid Oxidation and Is Decreased in Nonalcoholic Fatty Liver Disease

(2016) Liang Guo et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT3 deficiency impairs mitochondrial and contractile function in the heart

(2015) Christoph Koentges et al.   BASIC RESEARCH IN CARDIOLOGY

Mitochondrial complex I defect and increased fatty acid oxidation enhance protein lysine acetylation in the diabetic heart

(2015) Edwin J. Vazquez et al.   CARDIOVASCULAR RESEARCH

Monoamine oxidase-A is an important source of oxidative stress and promotes cardiac dysfunction, apoptosis, and fibrosis in diabetic cardiomyopathy

(2015) Prachi Umbarkar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling

(2014) Osama Abo Alrob et al.   CARDIOVASCULAR RESEARCH

SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis

(2014) Seo Young Shin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Enhanced hydrogen peroxide generation accompanies the beneficial bioenergetic effects of methylene blue in isolated brain mitochondria

(2014) L. Tretter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prolonged Fasting Identifies Heat Shock Protein 10 as a Sirtuin 3 Substrate

(2014) Zhongping Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonenzymatic Protein Acylation as a Carbon Stress Regulated by Sirtuin Deacylases

(2014) Gregory R. Wagner et al.   MOLECULAR CELL

Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae

(2014) B. T. Weinert et al.   Molecular Systems Biology

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

O18Quant: A Semiautomatic Strategy for Quantitative Analysis of High-Resolution16O/18O Labeled Data

(2014) Yan Guo et al.   Biomed Research International

Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure

(2013) Georgios Karamanlidis et al.   Cell Metabolism

Cyclophilin D Modulates Mitochondrial Acetylome

(2013) Tiffany Tuyen M. Nguyen et al.   CIRCULATION RESEARCH

Sirtuin 3 (SIRT3) Protein Regulates Long-chain Acyl-CoA Dehydrogenase by Deacetylating Conserved Lysines Near the Active Site

(2013) Sivakama S. Bharathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase

(2013) Gaëlle Laurent et al.   MOLECULAR CELL

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways

(2013) M. J. Rardin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic profiling and functional characterization of early and late shoulder osteoarthritis

(2013) John Wanner et al.   ARTHRITIS RESEARCH & THERAPY

Taking Diabetes to Heart—Deregulation of Myocardial Lipid Metabolism in Diabetic Cardiomyopathy

(2013) Marina Bayeva et al.   Journal of the American Heart Association

Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1

(2012) Iain Scott et al.   BIOCHEMICAL JOURNAL

Muscle-Specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic Flexibility

(2012) Deborah M. Muoio et al.   Cell Metabolism

Alternative Mitochondrial Electron Transfer as a Novel Strategy for Neuroprotection

(2011) Yi Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue

(2011) Julio C. Rojas et al.   PROGRESS IN NEUROBIOLOGY

The myocardial contractile response to physiological stress improves with high saturated fat feeding in heart failure

(2010) Jessica M. Berthiaume et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Methylene Blue Reduces Aβ Levels and Rescues Early Cognitive Deficit by Increasing Proteasome Activity

(2010) David X. Medina et al.   BRAIN PATHOLOGY

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden

(2010) John C O'Leary et al.   Molecular Neurodegeneration

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Diabetic cardiomyopathy, causes and effects

(2010) Sihem Boudina et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Adverse Effects of Methylene Blue on the Central Nervous System

(2009) Laszlo Vutskits et al.   ANESTHESIOLOGY

Rodent models of diabetic cardiomyopathy

(2009) H. Bugger et al.   Disease Models & Mechanisms

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

(2009) Nagalingam R. Sundaresan et al.   JOURNAL OF CLINICAL INVESTIGATION

Streptomyces erythraeusTrypsin for Proteomics Applications

(2009) Jianying Z. Kiser et al.   JOURNAL OF PROTEOME RESEARCH

Proteomic Changes in the Photoreceptor Outer Segment upon Intense Light Exposure

(2009) Dagmar Hajkova et al.   JOURNAL OF PROTEOME RESEARCH

Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation

(2008) Mariana G. Rosca et al.   CARDIOVASCULAR RESEARCH

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

Type 1 Diabetic Akita Mouse Hearts Are Insulin Sensitive but Manifest Structurally Abnormal Mitochondria That Remain Coupled Despite Increased Uncoupling Protein 3

(2008) H. Bugger et al.   DIABETES