Silencing Myeloid Netrin-1 Induces Inflammation Resolution and Plaque Regression

Netrin-1 in Atherosclerosis: Relationship between Human Macrophage Intracellular Levels and In Vivo Plaque Morphology

(2021) Susanna Fiorelli et al.   Biomedicines

Atherosclerosis: Making a U Turn

(2020) Ira J. Goldberg et al.   Annual Review of Medicine

The identification and function of a Netrin-1 mutation in a pedigree with premature atherosclerosis

(2020) C.S. Bruikman et al.   ATHEROSCLEROSIS

Enhanced glycolysis and HIF-1α activation in adipose tissue macrophages sustains local and systemic interleukin-1β production in obesity

(2020) Monika Sharma et al.   Scientific Reports

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

(2019) Dvir Aran et al.   NATURE IMMUNOLOGY

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

(2019) Magnus Bäck et al.   Nature Reviews Cardiology

Smooth Muscle Cells Contribute the Majority of Foam Cells in ApoE (Apolipoprotein E)-Deficient Mouse Atherosclerosis

(2019) Ying Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The role of macrophages in the resolution of inflammation

(2019) Satoshi Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

The PCSK9 revolution: Current status, controversies, and future directions

(2019) Bruce A. Warden et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

Endothelial Foxp1 Suppresses Atherosclerosis via Modulation of Nlrp3 Inflammasome Activation

(2019) Tao Zhuang et al.   CIRCULATION RESEARCH

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

(2019) Marco Orecchioni et al.   Frontiers in Immunology

From Subclinical Atherosclerosis to Plaque Progression and Acute Coronary Events

(2019) Amir Ahmadi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Netrin-1 and the Grade of Atherosclerosis Are Inversely Correlated in Humans

(2019) Caroline S. Bruikman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases CCR7 Expression in Plaque Macrophages

(2018) Paul A. Mueller et al.   CIRCULATION

Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018) Emelia J. Benjamin et al.   CIRCULATION

Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine AtherosclerosisNovelty and Significance

(2018) Clément Cochain et al.   CIRCULATION RESEARCH

Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial

(2018) Paul M Ridker et al.   LANCET

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

(2018) Arnau Hervera et al.   NATURE CELL BIOLOGY

S100A8/A9 in Inflammation

(2018) Siwen Wang et al.   Frontiers in Immunology

AAV8-mediated overexpression of mPCSK9 in liver differs between male and female mice

(2018) Aimee E. Vozenilek et al.   ATHEROSCLEROSIS

The role of UNC5b in ox-LDL inhibiting migration of RAW264.7 macrophages and the involvement of CCR7

(2018) Xi Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis

(2018) Kathryn J. Moore et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells

(2018) Tarik Hadi et al.   Nature Communications

Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression

(2017) Karishma Rahman et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial redox signaling enables repair of injured skeletal muscle cells

(2017) Adam Horn et al.   Science Signaling

Mitochondrial redox signaling enables repair of injured skeletal muscle cells

(2017) Adam Horn et al.   Science Signaling

Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis ModelsNovelty and Significance

(2016) Joel Chappell et al.   CIRCULATION RESEARCH

CCR7 Maintains Nonresolving Lymph Node and Adipose Inflammation in Obesity

(2016) Jason Hellmann et al.   DIABETES

Netrin-1 and its receptor Unc5b are novel targets for the treatment of inflammatory arthritis

(2016) Aránzazu Mediero et al.   FASEB JOURNAL

The neuroimmune guidance cue netrin-1 controls resolution programs and promotes liver regeneration

(2016) Martin Schlegel et al.   HEPATOLOGY

Truncated netrin-1 contributes to pathological vascular permeability in diabetic retinopathy

(2016) Khalil Miloudi et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

(2016) Ido Amit et al.   NATURE IMMUNOLOGY

Netrin-1 Reduces Monocyte and Macrophage Chemotaxis towards the Complement Component C5a

(2016) Lewis Taylor et al.   PLoS One

Regression of coronary atherosclerosis: Current evidence and future perspectives

(2016) Konstantinos C. Koskinas et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Development and Function of Arterial and Cardiac Macrophages

(2016) Filip K. Swirski et al.   TRENDS IN IMMUNOLOGY

MicroRNA-33–dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis

(2015) Mireille Ouimet et al.   JOURNAL OF CLINICAL INVESTIGATION

Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth

(2015) Sherine Ensan et al.   NATURE IMMUNOLOGY

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma

(2015) Bo-Kyung Son et al.   Nature Communications

Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation

(2015) J. Tang et al.   Science Advances

The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections

(2015) Wasim Abbas et al.   Frontiers in Oncology

Contribution of Intimal Smooth Muscle Cells to Cholesterol Accumulation and Macrophage-Like Cells in Human Atherosclerosis

(2014) Sima Allahverdian et al.   CIRCULATION

Regulation and consequences of monocytosis

(2014) Partha Dutta et al.   IMMUNOLOGICAL REVIEWS

Vagus nerve controls resolution and pro-resolving mediators of inflammation

(2014) Valbona Mirakaj et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity

(2014) Bhama Ramkhelawon et al.   NATURE MEDICINE

Dynamic Aspects of Macrophage Polarization during Atherosclerosis Progression and Regression

(2014) Michael Peled et al.   Frontiers in Immunology

The Influence of Innate and Adaptive Immune Responses on Atherosclerosis

(2013) Joseph L. Witztum et al.   Annual Review of Pathology-Mechanisms of Disease

Hypoxia Induces Netrin-1 and Unc5b in Atherosclerotic Plaques

(2013) Bhama Ramkhelawon et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial Expression of Guidance Cues in Vessel Wall Homeostasis Dysregulation Under Proatherosclerotic Conditions

(2013) Janine M. van Gils et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Association of Neuroimmune Guidance Cue Netrin-1 and Its Chemorepulsive Receptor UNC5B With Atherosclerotic Plaque Expression Signatures and Stability in Human(s)

(2013) Niku Oksala et al.   Circulation-Cardiovascular Genetics

Netrin-1 Attenuates Cardiac Ischemia Reperfusion Injury and Generates Alternatively Activated Macrophages

(2013) Xiaogang Mao et al.   INFLAMMATION

Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX3CR1hi cells

(2013) Gretchen E. Diehl et al.   NATURE

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

(2013) Clinton S Robbins et al.   NATURE MEDICINE

TGFβ signaling plays a critical role in promoting alternative macrophage activation

(2012) Dapeng Gong et al.   BMC IMMUNOLOGY

Smooth muscle cell phenotypic switching in atherosclerosis

(2012) D. Gomez et al.   CARDIOVASCULAR RESEARCH

Endoplasmic Reticulum Stress Controls M2 Macrophage Differentiation and Foam Cell Formation

(2012) Jisu Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques

(2012) Janine M van Gils et al.   NATURE IMMUNOLOGY

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe–/– mice during disease regression

(2011) Stephane Potteaux et al.   JOURNAL OF CLINICAL INVESTIGATION

Statins Promote the Regression of Atherosclerosis via Activation of the CCR7-Dependent Emigration Pathway in Macrophages

(2011) Jonathan E. Feig et al.   PLoS One

Resident Intimal Dendritic Cells Accumulate Lipid and Contribute to the Initiation of Atherosclerosis

(2009) Kim E. Paulson et al.   CIRCULATION RESEARCH

Netrin-1 prevents ischemia/reperfusion-induced myocardial infarction via a DCC/ERK1/2/eNOSs1177/NO/DCC feed-forward mechanism

(2009) Jun Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia

(2009) Peter Rosenberger et al.   NATURE IMMUNOLOGY